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Nwd1 Gene Detail
Summary
  • Symbol
    Nwd1
  • Name
    NACHT and WD repeat domain containing 1
  • Synonyms
    A230063L24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442268
    NCBI Gene: 319555
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:73372865-73443508 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1659 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442268
 protein coding gene Chr8:73372865-73444504 (+)
129S1/SvImJ ENSMUSG00200028846
 protein coding gene Chr8:67739491-67811271 (+)
A/J ENSMUSG00195013981
 protein coding gene Chr8:68084740-68156804 (+)
AKR/J ENSMUSG00220024435
 protein coding gene Chr8:68218035-68289828 (+)
BALB/cJ ENSMUSG00180021622
 protein coding gene Chr8:67923231-67995014 (+)
C3H/HeJ ENSMUSG00175019655
 protein coding gene Chr8:68061257-68133029 (+)
C57BL/6NJ ENSMUSG00215020200
 protein coding gene Chr8:67645633-67717694 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031225
 protein coding gene Chr8:64682645-64747617 (+)
CAST/EiJ ENSTCUG00005031365
 protein coding gene Chr8:67674321-67743440 (+)
CBA/J ENSMUSG00210031658
 protein coding gene Chr8:67968112-68039886 (+)
DBA/2J ENSMUSG00185012652
 protein coding gene Chr8:74128504-74200277 (+)
FVB/NJ ENSMUSG00205033959
 protein coding gene Chr8:67218196-67289980 (+)
JF1/MsJ ENSUMUG00000018955
 protein coding gene Chr8:76453085-76522369 (+)
LP/J ENSMUSG00230028774
 protein coding gene Chr8:77774492-77846234 (+)
NOD/ShiLtJ ENSMUSG00190023419
 protein coding gene Chr8:67957631-68029686 (+)
NZO/HlLtJ ENSMUSG00225022816
 protein coding gene Chr8:81140083-81211862 (+)
PWK/PhJ ENSLUMG00010034141
 protein coding gene Chr8:67856584-67926012 (+)
SPRET/EiJ ENSMSPG00010036477
 protein coding gene Chr8:69608129-69676426 (+)
WSB/EiJ ENSIUOG00005020803
 protein coding gene Chr8:68733353-68805204 (+)



Homology
more
  • Human Ortholog
    NWD1, NACHT and WD repeat domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NWD1, NACHT and WD repeat domain containing 1
  • Links
    NCBI Gene ID: 284434
    UniProt: Q149M9

  • Chr Location
    19p13.11; chr19:16719847-16817963 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nwd1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit hepatomegaly, liver fibrosis and lipid accumulation, pyroptosis of hepatocytes, and defective lipid droplet efflux from the sinusoids, resembling metabolic dysfunction-associated steatohepatitis (MASH), and increased leukocyte number and flattened alveoli in the lungs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    88
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 319555 NCBI Gene Model | MGI Sequence Detail 70644 C57BL/6J ±  kb
    transcript NM_176940 RefSeq | MGI Sequence Detail 7732 C57BL/6  
    polypeptide A6H603 UniProt | EBI | MGI Sequence Detail 1563 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000030916 NACHT domain- and WD repeat-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR025139 Domain of unknown function DUF4062
      IPR060769 EIF3B-like, beta-propeller domain superfamily
      IPR043365 NACHT domain- and WD repeat-containing protein 1
      IPR007111 NACHT nucleoside triphosphatase
      IPR057588 NWD1/2-like, winged helix-turn-helix domain
      IPR020472 PAC1/LIS1-like, WD-40 repeat
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9
      Antibodies 1
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:363603 Yamada S, et al., Induction of MASH-like pathogenesis in the Nwd1(-/-) mouse liver. Commun Biol. 2025 Mar 11;8(1):348
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory