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Chp1 Gene Detail
Summary
  • Symbol
    Chp1
  • Name
    calcineurin-like EF hand protein 1
  • Synonyms
    1500003O03Rik, Sid470p, vac
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927185
    NCBI Gene: 56398
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119378178-119417508 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.97 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    865 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927185
 protein coding gene Chr2:119378172-119417508 (+)
129S1/SvImJ ENSMUSG00200046005
 protein coding gene Chr2:116315678-116355083 (+)
A/J ENSMUSG00195022443
 protein coding gene Chr2:116369668-116409307 (+)
AKR/J ENSMUSG00220036631
 protein coding gene Chr2:116281135-116320573 (+)
BALB/cJ ENSMUSG00180038451
 protein coding gene Chr2:116170031-116209672 (+)
C3H/HeJ ENSMUSG00175024549
 protein coding gene Chr2:116634625-116674303 (+)
C57BL/6NJ ENSMUSG00215017638
 protein coding gene Chr2:116295560-116334888 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024146
 protein coding gene Chr2:112382848-112420309 (+)
CAST/EiJ ENSTCUG00005015695
 protein coding gene Chr2:115567413-115606851 (+)
CBA/J ENSMUSG00210006917
 protein coding gene Chr2:116475607-116515292 (+)
DBA/2J ENSMUSG00185041278
 protein coding gene Chr2:116167769-116207403 (+)
FVB/NJ ENSMUSG00205036408
 protein coding gene Chr2:115381925-115421348 (+)
JF1/MsJ ENSUMUG00000019197
 protein coding gene Chr2:116037037-116083590 (+)
LP/J ENSMUSG00230016399
 protein coding gene Chr2:117975366-118014766 (+)
NOD/ShiLtJ ENSMUSG00190044228
 protein coding gene Chr2:116403852-116443525 (+)
NZO/HlLtJ ENSMUSG00225003880
 protein coding gene Chr2:125881513-125921927 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010036459
 protein coding gene Chr2:118347440-118387105 (+)
WSB/EiJ ENSIUOG00005024226
 protein coding gene Chr2:116131723-116171366 (+)



Homology
more
  • Human Ortholog
    CHP1, calcineurin like EF-hand protein 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHP1, calcineurin like EF-hand protein 1
  • Synonyms
    CHP, p22, p24, Sid470p, SLC9A1BP, SPAX9
  • Links
    NCBI Gene ID: 11261
    UniProt: Q99653

  • Chr Location
    15q15.1; chr15:41230824-41281888 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CHP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 3 genetic backgrounds
    5 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, embryonic growth retardation, abnormal head shape and allantois morphology, incomplete embryo turning and rostral neuropore closure, abnormal cardiac development, yolk sac and placentation defects, and complete lethality during organogenesis. Mice homozygous for an ENU-induced allele display ataxia and progressive Purkinje cell axonal dystrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    651
  • Tissues
    32
  • cDNA Data
    325
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014077 Ensembl Gene Model | MGI Sequence Detail 39331 C57BL/6J ±  kb
    transcript ENSMUST00000014221 Ensembl | MGI Sequence Detail 2609 Not Applicable  
    polypeptide ENSMUSP00000014221 Ensembl | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 326
      cDNA 325
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915310, MGI:2146369, MGI:2146375, MGI:5438383
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:386951 Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory