Cdk13 MGI Mouse Gene Detail - MGI:1916812 - cyclin dependent kinase 13

Symbol

Cdk13
Name

cyclin dependent kinase 13
Synonyms

2310015O17Rik, Cdc2l5

Feature Type

protein coding gene
IDs

MGI:1916812
NCBI Gene: 69562
Alliance

genome feature page
Transcription Start Sites

13 TSS

Sequence Map

Chr13:17885309-17979960 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 6.05 cM, cytoband A3.1
Mapping Data

2 experiments

SNPs within 2kb

1648 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916812	protein coding gene	Chr13:17884900-17979960 (-)
129S1/SvImJ	ENSMUSG00200013683	protein coding gene	Chr13:15123886-15218669 (-)
A/J	ENSMUSG00195035373	protein coding gene	Chr13:14227249-14328210 (-)
AKR/J	ENSMUSG00220031638	protein coding gene	Chr13:14179867-14268614 (-)
BALB/cJ	ENSMUSG00180035719	protein coding gene	Chr13:14581874-14682830 (-)
C3H/HeJ	ENSMUSG00175031791	protein coding gene	Chr13:14683661-14784601 (-)
C57BL/6NJ	ENSMUSG00215018038	protein coding gene	Chr13:14641081-14735908 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018246	protein coding gene	Chr13:13117041-13206989 (-)
CAST/EiJ	ENSTCUG00005013426	protein coding gene	Chr13:14735793-14829888 (-)
CBA/J	ENSMUSG00210029660	protein coding gene	Chr13:14543597-14644539 (-)
DBA/2J	ENSMUSG00185012472	protein coding gene	Chr13:15238477-15345881 (-)
FVB/NJ	ENSMUSG00205021984	protein coding gene	Chr13:14410739-14505537 (-)
JF1/MsJ	ENSUMUG00000015045	protein coding gene	Chr13:14995593-15084392 (-)
LP/J	ENSMUSG00230031421	protein coding gene	Chr13:24647364-24748302 (-)
NOD/ShiLtJ	ENSMUSG00190020769	protein coding gene	Chr13:14514559-14609331 (-)
NZO/HlLtJ	ENSMUSG00225032313	protein coding gene	Chr13:18404114-18498940 (-)
PWK/PhJ	ENSLUMG00010025858	protein coding gene	Chr13:13964641-14053383 (-)
SPRET/EiJ	ENSMSPG00010018893	protein coding gene	Chr13:13626295-13709928 (-)
WSB/EiJ	ENSIUOG00005031635	protein coding gene	Chr13:13849481-13944271 (-)

Human Ortholog

CDK13, cyclin dependent kinase 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK13, cyclin dependent kinase 13
Synonyms

CDC2L, CDC2L5, CHDFIDD, CHED, hCDK13
Links

HGNC:1733

NCBI Gene ID: 8621

UniProt: Q14004
Chr Location

7p14.1; chr7:39950121-40099580 (+) GRCh38

MGI Vertebrate Homology

Cdk13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK13
Gene Tree

Cdk13

Diseases

1 with Cdk13 mouse models; 4 with human CDK13 associations

Human Disease

Mouse Models

congenital heart defects, dysmorphic facial features, and intellectual developmental disorder

IDs

View 1 model

hepatocellular carcinoma

IDs

intellectual disability

IDs

prostate carcinoma

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

33 phenotypes from 3 alleles in 4 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

8
Gene trapped

8
Radiation induced

1
Targeted

5
Genomic Mutations

1 involving Cdk13
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

42
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

674
Tissues

46
cDNA Data

14
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdk13

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All Sequences

66
RefSeq

12
UniProt

5
CCDS

CCDS36604.1, CCDS88417.1

Ensembl

ENSMUSG00000041297 (Evidence)
NCBI Gene

69562

			Length	Strain/Species	Flank
genomic	69562	NCBI Gene Model \| MGI Sequence Detail	94652	C57BL/6J	± kb
transcript	NM_001081058	RefSeq \| MGI Sequence Detail	7081	Not Specified
polypeptide	Q69ZA1	UniProt \| EBI \| MGI Sequence Detail	1511	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005198 cyclin-dependent kinase 13

(term hierarchy)
EC

2.7.11.1, 2.7.11.22, 2.7.11.23
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q69ZA1 14 sites, 1 O-linked glycan (14 sites)

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All nucleic 16

cDNA 14

Primer pair 1

Other 1

Antibodies 2

Microarray probesets 5

Summaries

All 58

Developmental Gene Expression 4

Diseases 1

Gene Ontology 13

Phenotypes 21
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:360529 Waheed-Ullah Q, et al., Cyclin-dependent kinase 13 is indispensable for normal mouse heart development. J Anat. 2025 Apr;246(4):616-630

TSS for Cdk13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121535	Chr13:17979891-17979953 (-)	38 bp
Tssr121534	Chr13:17979678-17979774 (-)	234 bp
Tssr121533	Chr13:17979567-17979610 (-)	371 bp
Tssr121532	Chr13:17979531-17979553 (-)	418 bp
Tssr121531	Chr13:17971961-17971966 (-)	7,996 bp
Tssr121530	Chr13:17965200-17965212 (-)	14,754 bp
Tssr121529	Chr13:17963836-17963858 (-)	16,113 bp
Tssr121528	Chr13:17958190-17958195 (-)	21,767 bp
Tssr121527	Chr13:17951078-17951081 (-)	28,880 bp
Tssr121526	Chr13:17947278-17947329 (-)	32,656 bp
Tssr121525	Chr13:17927563-17927571 (-)	52,393 bp
Tssr121524	Chr13:17918637-17918640 (-)	61,321 bp
Tssr121523	Chr13:17917342-17917345 (-)	62,616 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24