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Sharpin Gene Detail
Summary
  • Symbol
    Sharpin
  • Name
    SHANK-associated RH domain interacting protein
  • Synonyms
    0610041B22Rik, cpdm, SIPL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913331
    NCBI Gene: 106025
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76231240-76235310 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913331
 protein coding gene Chr15:76231240-76235311 (-)
129S1/SvImJ ENSMUSG00200050033
 protein coding gene Chr15:73345656-73351410 (-)
A/J ENSMUSG00195050214
 protein coding gene Chr15:73320116-73325870 (-)
AKR/J ENSMUSG00220047436
 protein coding gene Chr15:73331136-73336890 (-)
BALB/cJ ENSMUSG00180051532
 protein coding gene Chr15:73145263-73151017 (-)
C3H/HeJ ENSMUSG00175051758
 protein coding gene Chr15:73508688-73514442 (-)
C57BL/6NJ ENSMUSG00215048034
 protein coding gene Chr15:73237486-73243240 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019922
 protein coding gene Chr15:70295423-70299429 (-)
CAST/EiJ ENSTCUG00005039857
 protein coding gene Chr15:72850729-72856476 (-)
CBA/J ENSMUSG00210036835
 protein coding gene Chr15:73283927-73289681 (-)
DBA/2J ENSMUSG00185048293
 protein coding gene Chr15:73261098-73266852 (-)
FVB/NJ ENSMUSG00205049241
 protein coding gene Chr15:73013379-73019133 (-)
JF1/MsJ ENSUMUG00000051292
 protein coding gene Chr15:72911608-72917362 (-)
LP/J ENSMUSG00230052450
 protein coding gene Chr15:76626619-76632373 (-)
NOD/ShiLtJ ENSMUSG00190051721
 protein coding gene Chr15:73266005-73271752 (-)
NZO/HlLtJ ENSMUSG00225049947
 protein coding gene Chr15:76931163-76936910 (-)
PWK/PhJ ENSLUMG00010047569
 protein coding gene Chr15:73203560-73209307 (-)
SPRET/EiJ ENSMSPG00010043280
 protein coding gene Chr15:74809965-74815271 (-)
WSB/EiJ ENSIUOG00005036224
 protein coding gene Chr15:73323916-73329670 (-)



Homology
more
  • Human Ortholog
    SHARPIN, SHANK associated RH domain interactor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHARPIN, SHANK associated RH domain interactor
  • Synonyms
    AIFID, SIPL1
  • Links
    NCBI Gene ID: 81858
    UniProt: Q9H0F6

  • Chr Location
    8q24.3; chr8:144097513-144108124 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sharpin mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene produces chronic skin lesions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    644
  • Tissues
    28
  • cDNA Data
    66
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 106025 NCBI Gene Model | MGI Sequence Detail 4071 C57BL/6J ±  kb
    transcript NM_025340 RefSeq | MGI Sequence Detail 1747 Not Specified  
    polypeptide Q91WA6 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 66
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2104, MGI:2146193, MGI:88480
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 6
      Diseases 4
      Gene Ontology 15
      Phenotypes 100
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory