Sequence Detail

ID/Version

Q91WA6 Q8CHL3 Q7TNT3 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Sharpin;AltName: Full=Shank-associated RH domain-interacting protein;AltName: Full=Shank-interacting protein-like 1; Short=mSIPL1;

Provider

SWISS-PROT

Sequence

Polypeptide 380 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sharpin	SHANK-associated RH domain interacting protein	40	100	3	16

Sequence references in MGI

J:103585 Daigo Y, et al., Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse. J Gastroenterol Hepatol. 2003 Jun;18(6):712-8
J:121810 Seymour RE, et al., Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immun. 2007 Jul;8(5):416-21
J:170302 Ikeda F, et al., SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. Nature. 2011 Mar 31;471(7340):637-41
J:170809 Tokunaga F, et al., SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex. Nature. 2011 Mar 31;471(7340):633-6
J:170810 Gerlach B, et al., Linear ubiquitination prevents inflammation and regulates immune signalling. Nature. 2011 Mar 31;471(7340):591-6
J:182100 Liang Y, et al., Inhibition of NF-kappaB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice. J Invest Dermatol. 2011 Jan;131(1):141-9
J:187563 Landgraf K, et al., Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development. Mol Cell Biol. 2010 Dec;30(24):5764-75
J:244505 Renninger ML, et al., Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in Sharpin-deficient mice. Exp Dermatol. 2010 Mar;19(3):252-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89