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Kif3a Gene Detail
Summary
  • Symbol
    Kif3a
  • Name
    kinesin family member 3A
  • Synonyms
    Kif3, Kifl, kinesin-II subunit, Kns3, N-4 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:107689
    NCBI Gene: 16568
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:53458206-53492794 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.97 cM, cytoband A5-B1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1242 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107689
 protein coding gene Chr11:53456531-53495075 (+)
129S1/SvImJ ENSMUSG00200038259
 protein coding gene Chr11:50454055-50488648 (+)
A/J ENSMUSG00195034930
 protein coding gene Chr11:50391317-50425905 (+)
AKR/J ENSMUSG00220034934
 protein coding gene Chr11:50580233-50614821 (+)
BALB/cJ ENSMUSG00180033158
 protein coding gene Chr11:50452763-50487353 (+)
C3H/HeJ ENSMUSG00175037090
 protein coding gene Chr11:50422618-50457207 (+)
C57BL/6NJ ENSMUSG00215023905
 protein coding gene Chr11:50245418-50280006 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016341
 protein coding gene Chr11:48508500-48543031 (+)
CAST/EiJ ENSTCUG00005038679
 protein coding gene Chr11:50017140-50051460 (+)
CBA/J ENSMUSG00210026552
 protein coding gene Chr11:50278550-50313139 (+)
DBA/2J ENSMUSG00185027143
 protein coding gene Chr11:50490540-50525134 (+)
FVB/NJ ENSMUSG00205031562
 protein coding gene Chr11:50320905-50355494 (+)
JF1/MsJ ENSUMUG00000016579
 protein coding gene Chr11:50860584-50895016 (+)
LP/J ENSMUSG00230043475
 protein coding gene Chr11:51671722-51706315 (+)
NOD/ShiLtJ ENSMUSG00190027642
 protein coding gene Chr11:50548813-50583177 (+)
NZO/HlLtJ ENSMUSG00225030746
 protein coding gene Chr11:53712694-53747291 (+)
PWK/PhJ ENSLUMG00010030716
 protein coding gene Chr11:50310807-50345164 (+)
SPRET/EiJ ENSMSPG00010016148
 protein coding gene Chr11:50998770-51033141 (+)
WSB/EiJ ENSIUOG00005039241
 protein coding gene Chr11:50326954-50361310 (+)



Homology
more
  • Human Ortholog
    KIF3A, kinesin family member 3A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF3A, kinesin family member 3A
  • Synonyms
    FLA10, KLP-20
  • Links
    NCBI Gene ID: 11127
    UniProt: Q9Y496

  • Chr Location
    5q31.1; chr5:132688812-132737638 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Kif3a mouse models; 2 with human KIF3A associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    104 phenotypes from 4 alleles in 10 genetic backgrounds
    5 phenotypes from multigenic genotypes
    9 images
    122 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations result in embryonic lethality, failure to synthesize cilia in the embryonic node, randomization of left-right asymmetry and structural abnormalities of the neural tube, pericardium, branchial arches, and somites.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    114
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    678
  • Tissues
    46
  • cDNA Data
    17
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018395 Ensembl Gene Model | MGI Sequence Detail 34589 C57BL/6J ±  kb
    transcript ENSMUST00000118353 Ensembl | MGI Sequence Detail 2178 Not Applicable  
    polypeptide ENSMUSP00000113848 Ensembl | MGI Sequence Detail 725 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 6
      cDNA 19
      Primer pair 5
      Other 3
      Antibodies 8

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11592, MGD-MRK-36264, MGI:2136248, MGI:2136249, MGI:2144502, MGI:894290
    References
    more
    • Summaries
      All 224
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 41
      Phenotypes 122
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:391278 Kim JM, et al., Exercise-stimulated primary cilia on preosteoclasts promote periosteal-bone formation. Exp Mol Med. 2026 Jul;58(7):2168-2183
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory