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Mttp Gene Detail
Summary
  • Symbol
    Mttp
  • Name
    microsomal triglyceride transfer protein
  • Synonyms
    1810043K16Rik, MTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:106926
    NCBI Gene: 17777
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:137795616-137849179 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 64.06 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1946 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106926
 protein coding gene Chr3:137795615-137850729 (-)
129S1/SvImJ ENSMUSG00200002910
 protein coding gene Chr3:134589239-134640631 (-)
A/J ENSMUSG00195004181
 protein coding gene Chr3:134697622-134749014 (-)
AKR/J ENSMUSG00220002962
 protein coding gene Chr3:133148205-133199600 (-)
BALB/cJ ENSMUSG00180011244
 protein coding gene Chr3:134611736-134663111 (-)
C3H/HeJ ENSMUSG00175018614
 protein coding gene Chr3:134215073-134266456 (-)
C57BL/6NJ ENSMUSG00215018233
 protein coding gene Chr3:134954651-135008192 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025675
 protein coding gene Chr3:131244799-131613571 (-)
CAST/EiJ ENSTCUG00005028593
 protein coding gene Chr3:135302838-135354665 (-)
CBA/J ENSMUSG00210030952
 protein coding gene Chr3:134824918-134876290 (-)
DBA/2J ENSMUSG00185003306
 protein coding gene Chr3:135442067-135493467 (-)
FVB/NJ ENSMUSG00205016472
 protein coding gene Chr3:133749736-133801127 (-)
JF1/MsJ ENSUMUG00000004267
 protein coding gene Chr3:134206532-134257867 (-)
LP/J ENSMUSG00230002413
 protein coding gene Chr3:137402962-137454364 (-)
NOD/ShiLtJ ENSMUSG00190004357
 protein coding gene Chr3:135823348-135874749 (-)
NZO/HlLtJ ENSMUSG00225004498
 protein coding gene Chr3:139870955-139922353 (-)
PWK/PhJ ENSLUMG00010020294
 protein coding gene Chr3:134123800-134175010 (-)
SPRET/EiJ ENSMSPG00010014020
 protein coding gene Chr3:135295873-135347231 (-)
WSB/EiJ ENSIUOG00005017714
 protein coding gene Chr3:134981260-135034979 (-)



Homology
more
  • Human Ortholog
    MTTP, microsomal triglyceride transfer protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTTP, microsomal triglyceride transfer protein
  • Synonyms
    ABL, MTP
  • Links
    NCBI Gene ID: 4547
    UniProt: P55157

  • Chr Location
    4q23; chr4:99564081-99623997 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human MTTP associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most embryos homozygous for a reporter allele die at midgestation displaying delayed growth, neurodevelopmental anomalies, impaired erythropoiesis, deficient yolk sac lipoprotein production, hemorrhage and necrosis. Heterozygous mutant mice display altered plasma lipid and lipoprotein profiles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    107
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    688
  • Tissues
    50
  • cDNA Data
    52
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17777 NCBI Gene Model | MGI Sequence Detail 53564 C57BL/6J ±  kb
    transcript NM_001355052 RefSeq | MGI Sequence Detail 4504 ZRU/MplStud  
    polypeptide O08601 UniProt | EBI | MGI Sequence Detail 894 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003392 microsomal triglyceride transfer protein large subunit
      (term hierarchy)
    • InterPro Domains
      IPR015819 Lipid transport protein, beta-sheet shell
      IPR011030 Lipovitellin-phosvitin complex, superhelical domain
      IPR039988 Microsomal triglyceride transfer protein large subunit
      IPR045811 MTP large subunit, lipid-binding domain
      IPR015816 Vitellinogen, beta-sheet N-terminal
      IPR001747 Vitellogenin, middle region
      IPR063611 Vitellogenin, N-terminal domain
    • GlyGen
      O08601 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 53
      Primer pair 3
      Other 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35387, MGI:1917046
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 20
      Phenotypes 70
    • Earliest
      J:42428 Knecht TP, et al., The influence of molecular biology on our understanding of lipoprotein metabolism and the pathobiology of atherosclerosis. Adv Genet. 1995;32:141-98
    • Latest
      J:374743 Davies B, et al., Mutagenesis on a complex mouse genetic background by site-specific nucleases. Transgenic Res. 2024 Oct;33(5):415-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory