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Ccl11 Gene Detail
Summary
  • Symbol
    Ccl11
  • Name
    C-C motif chemokine ligand 11
  • Synonyms
    eotaxin, Scya11
  • Feature Type
    protein coding gene
  • IDs
    MGI:103576
    NCBI Gene: 20292
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:81948658-81953781 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 49.84 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    212 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103576
 protein coding gene Chr11:81948649-81953781 (+)
129S1/SvImJ ENSMUSG00200047660
 protein coding gene Chr11:79071098-79076230 (+)
A/J ENSMUSG00195037598
 protein coding gene Chr11:78937098-78942232 (+)
AKR/J ENSMUSG00220047738
 protein coding gene Chr11:79172346-79177492 (+)
BALB/cJ ENSMUSG00180037284
 protein coding gene Chr11:79136856-79141986 (+)
C3H/HeJ ENSMUSG00175033566
 protein coding gene Chr11:79107509-79112641 (+)
C57BL/6NJ ENSMUSG00215040561
 protein coding gene Chr11:78732128-78737266 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016849
 protein coding gene Chr11:77071924-77077067 (+)
CAST/EiJ ENSTCUG00005043254
 protein coding gene Chr11:78640040-78645201 (+)
CBA/J ENSMUSG00210037476
 protein coding gene Chr11:78925254-78930386 (+)
DBA/2J ENSMUSG00185031799
 protein coding gene Chr11:79196490-79201622 (+)
FVB/NJ ENSMUSG00205044537
 protein coding gene Chr11:79012940-79018074 (+)
JF1/MsJ ENSUMUG00000052084
 protein coding gene Chr11:79589911-79595110 (+)
LP/J ENSMUSG00230042458
 protein coding gene Chr11:80226612-80231744 (+)
NOD/ShiLtJ ENSMUSG00190040492
 protein coding gene Chr11:79248544-79253678 (+)
NZO/HlLtJ ENSMUSG00225038751
 protein coding gene Chr11:82401790-82406922 (+)
PWK/PhJ ENSLUMG00010020937
 protein coding gene Chr11:79111648-79116802 (+)
SPRET/EiJ ENSMSPG00010037206
 protein coding gene Chr11:79520144-79524925 (+)
WSB/EiJ ENSIUOG00005032113
 protein coding gene Chr11:79084099-79089284 (+)



Homology
more
  • Human Ortholog
    CCL11, C-C motif chemokine ligand 11
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL11, C-C motif chemokine ligand 11
  • Synonyms
    SCYA11
  • Links
    NCBI Gene ID: 6356
    UniProt: P51671

  • Chr Location
    17q12; chr17:34285742-34288334 (+)  GRCh38
  • Human Ortholog
    CCL13, C-C motif chemokine ligand 13
  • Synonyms
    CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1
  • Links
    NCBI Gene ID: 6357
    UniProt: Q99616

  • Chr Location
    17q12; chr17:34356480-34358610 (+)  GRCh38
  • Human Ortholog
    CCL8, C-C motif chemokine ligand 8
  • Synonyms
    HC14, MCP-2, MCP2, SCYA10, SCYA8
  • Links
    NCBI Gene ID: 6355
    UniProt: P80075

  • Chr Location
    17q12; chr17:34319435-34321402 (+)  GRCh38
Human Diseases
more
  • Diseases
    24 with human CCL11,CCL13,CCL2,CCL7 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display decreased numbers of eosinophils and impaired eosinophil recruitment after antigen challenge. However, a different homozygous disruption does not result in eosinophil abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    54
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    615
  • Tissues
    9
  • cDNA Data
    16
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20292 NCBI Gene Model | MGI Sequence Detail 5124 C57BL/6J ±  kb
transcript NM_011330 RefSeq | MGI Sequence Detail 1073 ZRU/MplStud  
polypeptide P48298 UniProt | EBI | MGI Sequence Detail 97 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 2
    cDNA 18
    Primer pair 3
    Antibodies 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-24461
References
more
  • Summaries
    All 191
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 49
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:371355 Immler R, et al., CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2319057121
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory