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Tcf12 Gene Detail
Summary
  • Symbol
    Tcf12
  • Name
    transcription factor 12
  • Synonyms
    ALF1, bHLHb20, HEB, HEBAlt, HTF-4, HTF4, ME1, REB
Location &
Maps
more
  • Sequence Map
    Chr9:71751534-72019611 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.85 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4973 from dbSNP Build 142
  • Strain Annotations
    30
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101877
 protein coding gene Chr9:71749970-72019611 (-)
129S1/SvImJ ENSMUSG00200040896
 protein coding gene Chr9:68817996-68864645 (-)
129S1/SvImJ ENSMUSGG00200054898
 protein coding gene Chr9:68961134-69071697 (-)
A/J ENSMUSG00195024448
 protein coding gene Chr9:68616245-68663196 (-)
A/J ENSMUSGG00195055441
 protein coding gene Chr9:68759702-68870367 (-)
AKR/J ENSMUSGG00220054560
 protein coding gene Chr9:68924090-69034515 (-)
AKR/J ENSMUSG00220036648
 protein coding gene Chr9:68773428-68820059 (-)
BALB/cJ ENSMUSG00180015250
 protein coding gene Chr9:68730599-68777538 (-)
BALB/cJ ENSMUSGG00180055530
 protein coding gene Chr9:68874067-68984734 (-)
C3H/HeJ ENSMUSG00175012424
 protein coding gene Chr9:68743802-68790750 (-)
C3H/HeJ ENSMUSGG00175054819
 protein coding gene Chr9:68887278-68997931 (-)
C57BL/6NJ ENSMUSGG00215055794
 protein coding gene Chr9:68854700-68965126 (-)
C57BL/6NJ ENSMUSG00215026866
 protein coding gene Chr9:68704040-68750671 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032415
 protein coding gene Chr9:68982362-69241246 (-)
CAST/EiJ ENSTCUG00005031454
 protein coding gene Chr9:68540268-68594337 (-)
CBA/J ENSMUSGG00210054779
 protein coding gene Chr9:68967847-69078498 (-)
CBA/J ENSMUSG00210014092
 protein coding gene Chr9:68824372-68871307 (-)
DBA/2J ENSMUSG00185030404
 protein coding gene Chr9:68848219-68895155 (-)
DBA/2J ENSMUSGG00185057622
 protein coding gene Chr9:68991685-69102339 (-)
FVB/NJ ENSMUSGG00205054590
 protein coding gene Chr9:69265064-69375726 (-)
FVB/NJ ENSMUSG00205014692
 protein coding gene Chr9:69121592-69168531 (-)
JF1/MsJ ENSUMUG00000015119
 protein coding gene Chr9:68875287-68921913 (-)
LP/J ENSMUSGG00230055404
 protein coding gene Chr9:69156155-69266715 (-)
LP/J ENSMUSG00230021077
 protein coding gene Chr9:69013028-69059678 (-)
NOD/ShiLtJ ENSMUSG00190020232
 protein coding gene Chr9:68952313-68999247 (-)
NOD/ShiLtJ ENSMUSGG00190054776
 protein coding gene Chr9:69095768-69206424 (-)
NZO/HlLtJ ENSMUSGG00225055644
 protein coding gene Chr9:69298271-69408940 (-)
NZO/HlLtJ ENSMUSG00225045376
 protein coding gene Chr9:69154805-69201742 (-)
PWK/PhJ ENSLUMG00010025152
 protein coding gene Chr9:68807766-68854393 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005025437
 protein coding gene Chr9:68317950-68364598 (-)



Homology
more
  • Human Ortholog
    TCF12, transcription factor 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF12, transcription factor 12
  • Synonyms
    bHLHb20, CRS3, HEB, HH26, HsT17266, HTF4, p64, TCF-12
  • Links
    NCBI Gene ID: 6938
    UniProt: Q99081

  • Chr Location
    15q21.3; chr15:56918090-57299707 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TCF12 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 6 alleles in 9 genetic backgrounds
    29 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit postnatal lethality within two weeks of birth and a 50% reduction in the number of pro-B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    993
  • Tissues
    291
  • cDNA Data
    252
  • Literature Summary
    45
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21406 NCBI Gene Model | MGI Sequence Detail 268078 C57BL/6J ±  kb
    transcript NM_011544 RefSeq | MGI Sequence Detail 4707 ZRU/MplStud  
    polypeptide Q61286 UniProt | EBI | MGI Sequence Detail 706 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      20 Sequences
    • Protein Ontology
      PR:000016176 transcription factor 12
      (term hierarchy)
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR051098 Neuronal Differentiation E-box Binding Transcription Factors
    • GlyGen
      Q61286 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 265
      Genomic 1
      cDNA 254
      Primer pair 7
      Other 3
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18703
    References
    more
    • Summaries
      All 174
      Developmental Gene Expression 45
      Diseases 1
      Gene Ontology 15
      Phenotypes 61
    • Earliest
      J:18120 Sun XH, et al., Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol. 1991 Nov;11(11):5603-11
    • Latest
      J:390120 Trowe MO, et al., Mesenchymal WNT signaling coordinates epithelial and mesenchymal differentiation in the developing murine ureter. Cell Commun Signal. 2026 Jul 21;24(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory