Gene Expression Literature Summary

• Symbol: Tcf12
• Name: transcription factor 12
• ID: MGI:101877

41 matching records from 41 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	P
Immunohistochemistry (section)																		2			1		2						1	1
In situ RNA (section)							1	1	1	2	1			3		5	1	7		5	9		7	1	3	1	1		6	13
In situ RNA (whole mount)												2	1	2		1				1			2
Northern blot							1						1				1		1					1				2		3
RT-PCR	1	1	1	1	1	1								1	1		1		2		2	1		1					1	6
cDNA clones														1	1											1
RNase protection																														1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tcf12  transcription factor 12   (Synonyms: ALF1, bHLHb20, HEB, HEBAlt, HTF4, HTF-4, ME1, REB)
Results	Reference
2	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
1*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1	J:38665 Chen B, Lim RW, Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression. J Biol Chem. 1997 Jan 24;272(4):2459-63
1	J:42215 Dear TN, Hainzl T, Follo M, Nehls M, Wilmore H, Matena K, Boehm T, Identification of interaction partners for the basic-helix-loop-helix protein E47. Oncogene. 1997 Feb 27;14(8):891-8
1	J:175535 Deng Q, Andersson E, Hedlund E, Alekseenko Z, Coppola E, Panman L, Millonig JH, Brunet JF, Ericson J, Perlmann T, Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development. 2011 Aug;138(16):3399-408
1	J:292321 Fan X, Waardenberg AJ, Demuth M, Osteil P, Sun JQJ, Loebel DAF, Graham M, Tam PPL, Fossat N, TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation. Mol Cell Biol. 2020 May 14;40(11)
1	J:125313 Flora A, Garcia JJ, Thaller C, Zoghbi HY, The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15382-7
3*	J:152838 Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD, A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 9;29(36):11399-408
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
3*	J:331303 Kantzer CG, Yang W, Grommisch D, Patikl KV, Mak KH, Shirokova V, Genander M, ID1 and CEBPA coordinate epidermal progenitor cell differentiation. Development. 2022 Nov;149(22)
6*	J:50644 Krapp A, Knofler M, Frutiger S, Hughes GJ, Hagenbuchle O, Wellauer PK, The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein. EMBO J. 1996 Aug 15;15(16):4317-29
2	J:306027 Li H, Kurtzeborn K, Kupari J, Gui Y, Siefker E, Lu B, Matlik K, Olfat S, Montano-Rodriguez AR, Huh SH, Costantini F, Andressoo JO, Kuure S, Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF. Development. 2021 May 15;148(10):dev197475
2	J:185188 Li S, Mattar P, Zinyk D, Singh K, Chaturvedi CP, Kovach C, Dixit R, Kurrasch DM, Ma YC, Chan JA, Wallace V, Dilworth FJ, Brand M, Schuurmans C, GSK3 Temporally Regulates Neurogenin 2 Proneural Activity in the Neocortex. J Neurosci. 2012 Jun 6;32(23):7791-805
4	J:301718 Lowenstein ED, Rusanova A, Stelzer J, Hernaiz-Llorens M, Schroer AE, Epifanova E, Bladt F, Isik EG, Buchert S, Jia S, Tarabykin V, Hernandez-Miranda LR, Olig3 regulates early cerebellar development. Elife. 2021 Feb 16;10:e64684
2*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
4*	J:260421 Mesman S, Kruse SJ, Smidt MP, Expression analyzes of early factors in midbrain differentiation programs. Gene Expr Patterns. 2018 Jan;27:8-15
6	J:310537 Mesman S, Smidt MP, Tcf12 Is Involved in Early Cell-Fate Determination and Subset Specification of Midbrain Dopamine Neurons. Front Mol Neurosci. 2017;10:353
1	J:185583 Metzakopian E, Lin W, Salmon-Divon M, Dvinge H, Andersson E, Ericson J, Perlmann T, Whitsett JA, Bertone P, Ang SL, Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development. 2012 Jul;139(14):2625-34
2	J:92533 Murakami M, Kataoka K, Tominaga J, Nakagawa O, Kurihara H, Differential cooperation between dHAND and three different E-proteins. Biochem Biophys Res Commun. 2004 Oct 8;323(1):168-174
1	J:103817 Nef S, Schaad O, Stallings NR, Cederroth CR, Pitetti JL, Schaer G, Malki S, Dubois-Dauphin M, Boizet-Bonhoure B, Descombes P, Parker KL, Vassalli JD, Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development. Dev Biol. 2005 Nov 15;287(2):361-77
6	J:21814 Neuman T, Keen A, Knapik E, Shain D, Ross M, Nornes HO, Zuber MX, ME1 and GE1: basic helix-loop-helix transcription factors expressed at high levels in the developing nervous system and in morphogenetically active regions. Eur J Neurosci. 1993 Apr 1;5(4):311-8
2*	J:198109 Oeschger FM, Wang WZ, Lee S, Garcia-Moreno F, Goffinet AM, Arbones ML, Rakic S, Molnar Z, Gene expression analysis of the embryonic subplate. Cereb Cortex. 2012 Jun;22(6):1343-59
7	J:134786 Ravanpay AC, Olson JM, E protein dosage influences brain development more than family member identity. J Neurosci Res. 2008 May 15;86(7):1472-81
1	J:266826 Sandberg M, Flandin P, Silberberg S, Su-Feher L, Price JD, Hu JS, Kim C, Visel A, Nord AS, Rubenstein JLR, Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Neuron. 2016 Sep 21;91(6):1260-1275
3	J:335660 Scott IC, Anson-Cartwright L, Riley P, Reda D, Cross JC, The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Mol Cell Biol. 2000 Jan;20(2):530-41
2*	J:44393 Stewart HJ, Zoidl G, Rossner M, Brennan A, Zoidl C, Nave KA, Mirsky R, Jessen KR, Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development. J Neurosci Res. 1997 Dec 1;50(5):684-701
7	J:340405 Talley MJ, Nardini D, Ehrman LA, Lu QR, Waclaw RR, Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon. Neural Dev. 2023 Sep 8;18(1):5
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2*	J:321550 Ting MC, Farmer DT, Teng CS, He J, Chai Y, Crump JG, Maxson RE, Embryonic requirements for Tcf12 in the development of the mouse coronal suture. Development. 2022 Jan 1;149(1):dev199575
6	J:60116 Uittenbogaard M, Chiaramello A, Expression of the basic Helix-Loop-Helix ME1 E-protein during development and aging of the murine cerebellum. Neurosci Lett. 1999 Oct 29;274(3):191-4
9*	J:75719 Uittenbogaard M, Chiaramello A, Expression of the bHLH transcription factor Tcf12 (ME1) gene is linked to the expansion of precursor cell populations during neurogenesis. Brain Res Gene Expr Patterns. 2002 Jan;1(2):115-21
1	J:171421 Vandunk C, Hunter LA, Gray PA, Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci. 2011 Apr 27;31(17):6457-67
1	J:174191 Vernes SC, Oliver PL, Spiteri E, Lockstone HE, Puliyadi R, Taylor JM, Ho J, Mombereau C, Brewer A, Lowy E, Nicod J, Groszer M, Baban D, Sahgal N, Cazier JB, Ragoussis J, Davies KE, Geschwind DH, Fisher SE, Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain. PLoS Genet. 2011 Jul;7(7):e1002145
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*	J:288669 Wedel M, Frob F, Elsesser O, Wittmann MT, Lie DC, Reis A, Wegner M, Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic Acids Res. 2020 May 21;48(9):4839-4857
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
6	J:256883 Zhou J, Wang R, Zhang J, Zhu L, Liu W, Lu S, Chen P, Li H, Yin B, Yuan J, Qiang B, Shu P, Peng X, Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Biochim Biophys Acta. 2017 Dec;1860(12):1159-1168
1*	J:22134 Zhuang Y, Soriano P, Weintraub H, The helix-loop-helix gene E2A is required for B cell formation. Cell. 1994 Dec 2;79(5):875-84