Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:52296 Kuan AP, et al., Genetic control of autoimmune myocarditis mediated by myosin-specific antibodies [published erratum appears in Immunogenetics 1999 Jun;49(6):595-6]. Immunogenetics. 1999 Feb;49(2):79-85
• ID
  MGI:2149654

Genes

Gene	Assay Type
Abmm	visible phenotype
D12Mit133
Serpina1	reported elsewhere
Serpina3kr	reported elsewhere
Serpina3k	reported elsewhere
Gsc	reported elsewhere
Bdkrb2	reported elsewhere
Ckb	reported elsewhere
Mif-ps7	reported elsewhere
Dnahc13	reported elsewhere
Dync1h1	reported elsewhere
Iap3rc18	reported elsewhere
Iap3rc6	reported elsewhere
Traf3	reported elsewhere
Tnfaip2	reported elsewhere
Mse1	reported elsewhere
Igh	reported elsewhere
D12Mit277
D12Mit27
D12Mit8

Notes

• Experiment
  79 polymorphic markers were screened in 120 (BALB/cByJ x DBA/2J)F1 x DBA/2J backcross animals to identify loci associated with susceptibility to antibody-mediated autoimmune myocarditis. Following injection of myosin-specific antibodies, inbred strain DBA/2J develops myocarditis while inbred strain BALB/cJ is resistant to myocarditis. (BALB/cByJ x DBA/2J)F1 hybrid animals are resistant to myocarditis. A locus was detected on mouse Chromosome 12, Abmm (antibody-mediated myocarditis susceptibility), from 43 cM - 63 cM with peak significance P<0.0001 at D12Mit133. DBA/2J-derived alleles contribute to increased susceptibility to myocarditis 12-fold in female animals and 5-fold in all animals at this locus. Several candidate genes are found in this 15 cM interval: Serpina1 (Spi1), Serpina3kr, Serpina3k, Gsc, Bdkrb2, Ckb, Dnahc13, Dync1h1, Iap3rc18, Iaprc6, Traf3, Tnfaip2 (Tnfip2), Mse1, and Igh. Suggestive loci were also detected on mouse Chromosome 9 (P = 0.0014 at D9Mit19) at 38 cM and on distal mouse Chromosome1 (P =0.0003). Heterozygosity at the Chromosome 9 locus contributes to increased susceptibility to myocarditis, while homozygosity at the Chromosome 1 locus for DBA/2J-derived alleles contributes to increased susceptibility to myocarditis only in male animals.