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Serpina1 Complex/Cluster/Region Detail
Summary
  • Symbol
    Serpina1
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 1 cluster
  • Synonyms
    [a]1-antitrypsin, [a]1-PI, [a]1-proteinase inhibitor, Aat, alpha-1 antiproteinase, antitrypsin, Pre, Pre-1, Spi-1, Spi1
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:98376
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 12, cytoband E-F
  • Mapping Data
    99 experiments
Strain
Comparison
more
  • RFLP
    9
Human Diseases
more
  • Diseases
    2 with Serpina1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    14
  • Tissues
    8
  • cDNA Data
    12
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    Sequences &
    Gene Models
    less
    • All Sequences
      5
    Representative SequencesLengthStrain/SpeciesFlank
    transcript S70316 GenBank | ENA | DDBJ | MGI Sequence Detail 1373 M. saxicola  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 8
      cDNA 13
      Primer pair 2
      Antibodies 1
    Other
    Accession IDs
    less
    MGD-MRK-1011, MGD-MRK-13600, MGD-MRK-13601, MGD-MRK-14520, MGD-MRK-14525
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 9
      Diseases 1
      Phenotypes 2
    • Earliest
      J:12960 SHREFFLER DC, INHERITANCE OF A SERUM PRE-ALBUMIN VARIANT IN THE MOUSE. Genetics. 1964 Apr;49:629-34
    • Latest
      J:373624 Okagawa S, et al., Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression. Nat Commun. 2024 Nov 12;15(1):9585
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/07/2026
    MGI 6.24     		The Jackson Laboratory