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Tnfaip2 Gene Detail
Summary
  • Symbol
    Tnfaip2
  • Name
    tumor necrosis factor, alpha-induced protein 2
  • Synonyms
    Exoc3l3, M-sec, Tnfip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104960
    NCBI Gene: 21928
  • Alliance
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111408903-111421452 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 60.99 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104960
protein coding gene Chr12:111408898-111421452 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020133
protein coding gene Chr12:113829264-113841806 (+)
A/J MGP_AJ_G0020089
protein coding gene Chr12:109451359-109464527 (+)
AKR/J MGP_AKRJ_G0020064
protein coding gene Chr12:112586168-112598740 (+)
BALB/cJ MGP_BALBcJ_G0020074
protein coding gene Chr12:109868036-109880588 (+)
C3H/HeJ MGP_C3HHeJ_G0019876
protein coding gene Chr12:113086915-113099445 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020519
protein coding gene Chr12:117361596-117374237 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018132
protein coding gene Chr12:105893468-105906028 (+)
CAST/EiJ MGP_CASTEiJ_G0019417
protein coding gene Chr12:107925414-107937977 (+)
CBA/J MGP_CBAJ_G0019843
protein coding gene Chr12:121828283-121840810 (+)
DBA/2J MGP_DBA2J_G0019960
protein coding gene Chr12:108933043-108945576 (+)
FVB/NJ MGP_FVBNJ_G0019945
protein coding gene Chr12:107730437-107743020 (+)
LP/J MGP_LPJ_G0020035
protein coding gene Chr12:113643794-113656348 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019983
protein coding gene Chr12:124952924-124966692 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020548
protein coding gene Chr12:112096009-112108561 (+)
PWK/PhJ MGP_PWKPhJ_G0019178
protein coding gene Chr12:103571094-103584296 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018981
protein coding gene Chr12:106254456-106266878 (+)
WSB/EiJ MGP_WSBEiJ_G0019476
protein coding gene Chr12:113019017-113032558 (+)



Homology
more
  • Human Ortholog
    TNFAIP2, TNF alpha induced protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFAIP2, TNF alpha induced protein 2
  • Synonyms
    B94, EXOC3L3
  • Links
    NCBI Gene ID: 7127
    neXtProt AC: NX_Q03169
    UniProt: Q03169

  • Chr Location
    14q32.32; chr14:103121469-103137439 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Tnfaip2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop albuminuria, podocyte injury, with mitochondrial abnormalities and progressive focal segmental glomerulosclerosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021281 Ensembl Gene Model | MGI Sequence Detail 12550 C57BL/6J ±  kb
    transcript ENSMUST00000109792 Ensembl | MGI Sequence Detail 3284 Not Applicable  
    polypeptide ENSMUSP00000105415 Ensembl | MGI Sequence Detail 708 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15152, MGD-MRK-31033
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 2
      Phenotypes 9
    • Earliest
      J:16743 Wolf FW, et al., B94, a primary response gene inducible by tumor necrosis factor-alpha, is expressed in developing hematopoietic tissues and the sperm acrosome. J Biol Chem. 1994 Feb 4;269(5):3633-40
    • Latest
      J:340928 Barutta F, et al., Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy. Autophagy. 2023 Feb;19(2):505-524

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    04/02/2024
    MGI 6.23
    The Jackson Laboratory