Tnfaip2^tm1.1Ohno
Targeted Allele Detail

Summary

• Symbol: Tnfaip2^tm1.1Ohno
• Name: tumor necrosis factor, alpha-induced protein 2; targeted mutation 1.1, Hiroshi Ohno
• MGI ID: MGI:7564565
• Synonyms: M-Sec-KO, Mutant (deltaNeo)
• Gene: Tnfaip2 Location: Chr12:111408903-111421452 bp, + strand Genetic Position: Chr12, 60.99 cM
• Alliance: Tnfaip2^tm1.1Ohno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343202
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 and 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin selection cassette replaced exons 1-5. Cre-mediated recombination deleted the selection cassette. Western blot analysis confirmed absence of protein in podocytes. (J:343202)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip2 Mutation: 32 strains or lines available

References

• Original: J:343202 Barutta F, et al., Protective Role of the M-Sec-Tunneling Nanotube System in Podocytes. J Am Soc Nephrol. 2021 May 3;32(5):1114-1130
• All: 2 reference(s)