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Phenotype Images associated with this Allele
Nomenclature
Symbol: Gba1tm2Karl
Name: glucosylceramidase beta 1; targeted mutation 2, Stefan Karlsson
MGI ID: MGI:3764510
Synonyms: gbalnl
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Gba1tm2Karl/Gba1tm2Karl Tg(KRT14-cre)8Brn/? mice display a severe and rapidly progressive neurological diseaseGba1tm2Karl/Gba1tm2Karl
Tg(KRT14-cre)8Brn/?		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Gba1tm2Karl/Gba1tm2Karl (upper left) mice display a lethal skin phenotype whileGba1tm2Karl/Gba1tm2Karl Tg(KRT14-cre)8Brn/? (lower) mice display paralysisGba1tm2Karl/Gba1tm2Karlinvolves: 129S1/Sv * 129X1/SvJ
Gba1tm2Karl/Gba1tm2Karl
Tg(KRT14-cre)8Brn/?		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Gba1tm1Karl/Gba1tm1Karl Tg(Nes-cre)1Kln/? mice exhibit a more profound activation and proliferation of microglial cells than Gbatm2Karl/Gbatm2Karl Tg(KRT14-cre)8Brn/? miceGba1tm2Karl/Gba1tm2Karl
Tg(KRT14-cre)8Brn/?		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Gba1tm1Karl/Gba1tm1Karl
Tg(Nes-cre)1Kln/?		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Gba1tm2Karl/Gba1tm2Karl Tg(KRT14-cre)8Brn/? mice display Gaucher cells in the liver and spleenGba1tm2Karl/Gba1tm2Karl
Tg(KRT14-cre)8Brn/?		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Neuronal loss in Gba1tm2Karl/Gba1tm2Karl Tg(KRT14-cre)8Brn/? miceGba1tm2Karl/Gba1tm2Karl
Tg(KRT14-cre)8Brn/?		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Gba1tm2Karl/Gba1tm2Karl Tg(KRT14-cre)8Brn/? mice display astrogliosis and abnormal microgliaGba1tm2Karl/Gba1tm2Karl
Tg(KRT14-cre)8Brn/?		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory