Gene Expression Image Detail

Reference

Figure

ID

J:290119 Soleilhavoup C, et al., Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun. 2020 Jun 19;11(1):3111

1

MGI:8268986

Image

Caption

a-d: Whole mount immunostained E18.5 wild type and Nolz1-/- brain cleared by iDISCO. a: Arrow points to dopaminergic (DA) axon bundle running in parallel to the ventral midline. b, d: Arrows indicate midline crossing of DA axon bundle in Nolz1-/- mutant embryos. b Arrowhead points to axons terminating in front of the striatum. c Arrowhead points to normal DA innervation of striatum in Wt embryos, which is disrupted Nolz1-/- mutant embryos (arrowhead in d). Sagittal view in a, b and ventral view in c, d. e-x: Immunostained and beta-gal stained wild type and Nolz1-/- brain at E18.5. Arrows indicate midline crossing of DA axon bundles in the Nolz1-/- mutant hypothalamus (f). i, j Arrows point to the GP. Arrowheads pointing to immunopositive cells in the hypothalamus (e) and striatum (g, i) of Wt embryos. Arrow in (l) indicates double positive DA axons crossing the midline in Nolz1-/- mutant hypothalamus. o, p Dashed line indicates the width of the DA axon bundle extending from Nolz1-/- mutant midbrain. Arrows indicating immunopositive, beta-galactosidase-positive labelled cells in Nolz1^bgal/+ heterozygous (q, q', s) and Nolz1^bgal/bgal homozygous mutant (r, r', t) hypothalamus. Mb (midbrain), Str (striatum), GP (globus pallidus), Zi (Zona Incerta), Hth (hypothalamus). Scale bar: 1000 um (a-d), 200 um (e-x).

Copyright

This image is from Soleilhavoup C, Nat Commun 2020 Jun 19;11(1):3111, and is displayed under the terms of the Creative Commons Attribution 4.0 International License.

Associated
Assays

Label	Assay & Result Details (Gene Symbol)	Spatial Mapping
a	MGI:8270442 (Th)
u	MGI:8270447 (Slc6a3) MGI:8270491 (Zfp503)
b	MGI:8270442 (Th)
v	MGI:8270447 (Slc6a3) MGI:8270491 (Zfp503)
c	MGI:8270442 (Th)
w	MGI:8270447 (Slc6a3) MGI:8270491 (Zfp503)
d	MGI:8270442 (Th)
x	MGI:8270447 (Slc6a3) MGI:8270491 (Zfp503)
e	MGI:8270447 (Slc6a3) MGI:8270488 (Zfp503)
q'	MGI:8270491 (Zfp503)
f	MGI:8270447 (Slc6a3) MGI:8270488 (Zfp503)
r'	MGI:8270491 (Zfp503)
g	MGI:8270447 (Slc6a3) MGI:8270488 (Zfp503)
h	MGI:8270447 (Slc6a3) MGI:8270488 (Zfp503)
i	MGI:8270447 (Slc6a3) MGI:8270488 (Zfp503)
j	MGI:8270447 (Slc6a3) MGI:8270488 (Zfp503)
k	MGI:8270447 (Slc6a3) MGI:8270443 (Th)
l	MGI:8270447 (Slc6a3) MGI:8270443 (Th)
m	MGI:8270447 (Slc6a3) MGI:8270443 (Th)
n	MGI:8270447 (Slc6a3) MGI:8270443 (Th)
o	MGI:8270447 (Slc6a3) MGI:8270443 (Th)
p	MGI:8270447 (Slc6a3) MGI:8270443 (Th)
q	MGI:8270447 (Slc6a3) MGI:8270491 (Zfp503)
r	MGI:8270447 (Slc6a3) MGI:8270491 (Zfp503)
s	MGI:8270447 (Slc6a3) MGI:8270491 (Zfp503)
t	MGI:8270447 (Slc6a3) MGI:8270491 (Zfp503)