Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes XRCC4
  • Mouse genes Xrcc4
  • Rat genes Xrcc4
  • Zfish genes xrcc4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xrcc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity	Xrcc4	IMP		Mouse	MGI:MGI:3758502|PMID:14690602
Molecular Function	GO:0070975	FHA domain binding	XRCC4	IPI	UniProtKB:Q96T60	Human	PMID:15385968
Molecular Function	GO:0042802	identical protein binding	XRCC4	IPI	UniProtKB:Q13426	Human	PMID:16169070
Molecular Function	GO:0042802	identical protein binding	XRCC4	IPI	UniProtKB:Q13426	Human	PMID:21768349
Molecular Function	GO:0042802	identical protein binding	XRCC4	IPI	UniProtKB:Q13426	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	XRCC4	IPI	UniProtKB:Q13426	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	XRCC4	IPI	UniProtKB:Q13426	Human	PMID:32296183
Molecular Function	GO:0060090	molecular adaptor activity	XRCC4	EXP		Human	PMID:11702069
Molecular Function	GO:0003676	nucleic acid binding	XRCC4	EXP		Human	PMID:11702069
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:11702069
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q7Z2E3	Human	PMID:15380105
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q96T60	Human	PMID:15385968
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q0D2I5	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:O00499	Human	PMID:16275660
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q7Z2E3	Human	PMID:16439205
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9H9Q4	Human	PMID:16439205
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q7Z2E3	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P12956	Human	PMID:17124166
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:17290226
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q8IW19	Human	PMID:17353262
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:17389648
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9UBB9	Human	PMID:17389648
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q8IW19	Human	PMID:17396150
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9H9Q4	Human	PMID:18064046
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9H9Q4	Human	PMID:18158905
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9H9Q4	Human	PMID:21349273
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q96T60	Human	PMID:21637298
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9H9Q4-1	Human	PMID:21768349
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:22529269
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q8IW19	Human	PMID:23178593
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:23219551
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P12956	Human	PMID:24095731
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q2TB18	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q8IZU0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q13426-3	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:25934149
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P12956	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9H9Q4	Human	PMID:27437582
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9H9Q4	Human	PMID:28500754
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q8IW19	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q96T60	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9H9Q4	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9UGP5	Human	PMID:30250067
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q8IZU0	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:31548606
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q0D2I5	Human	PMID:31548606
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q0D2I5-5	Human	PMID:31548606
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9H9Q4	Human	PMID:31548606
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:O15499	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P43360	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q7Z3Y8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q8IZU0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q96T60	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:Q9NVX0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:9259561
Molecular Function	GO:0005515	protein binding	XRCC4	IPI	UniProtKB:P49917	Human	PMID:9809069
Cellular Component	GO:0000781	chromosome, telomeric region	Xrcc4	IDA		Mouse	MGI:MGI:3758502|PMID:14690602
Cellular Component	GO:0005829	cytosol	XRCC4	IDA		Human	PMID:9259561
Cellular Component	GO:0032807	DNA ligase IV complex	XRCC4	IDA		Human	PMID:9242410
Cellular Component	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	XRCC4	IDA		Human	PMID:15194694
Cellular Component	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	Xrcc4	IDA		Mouse	PMID:15194694
Cellular Component	GO:0070522	ERCC4-ERCC1 complex	Xrcc4	IDA		Mouse	MGI:MGI:3758502|PMID:14690602
Cellular Component	GO:0070419	nonhomologous end joining complex	XRCC4	IDA		Human	PMID:20383123
Cellular Component	GO:0070419	nonhomologous end joining complex	XRCC4	IDA		Human	PMID:25941166
Cellular Component	GO:0005654	nucleoplasm	XRCC4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	XRCC4	IDA		Human	PMID:25597996
Cellular Component	GO:0005634	nucleus	XRCC4	IDA		Human	PMID:12589063
Cellular Component	GO:0005634	nucleus	XRCC4	IDA		Human	PMID:25934149
Cellular Component	GO:0005634	nucleus	XRCC4	IDA		Human	PMID:9259561
Cellular Component	GO:0035861	site of double-strand break	XRCC4	IDA		Human	PMID:26774286
Cellular Component	GO:0035861	site of double-strand break	XRCC4	IDA		Human	PMID:27437582
Cellular Component	GO:0035861	site of double-strand break	XRCC4	IDA		Human	PMID:28500754
Cellular Component	GO:0035861	site of double-strand break	XRCC4	IDA		Human	PMID:31548606
Biological Process	GO:0071285	cellular response to lithium ion	Xrcc4	IEP		Rat	PMID:19285016|RGD:2317095
Biological Process	GO:0007417	central nervous system development	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:1904155	DN2 thymocyte differentiation	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:0006266	DNA ligation	Xrcc4	IDA		Mouse	PMID:15194694
Biological Process	GO:0051103	DNA ligation involved in DNA repair	XRCC4	IDA		Human	PMID:12517771
Biological Process	GO:0051103	DNA ligation involved in DNA repair	XRCC4	IDA		Human	PMID:15385968
Biological Process	GO:0051103	DNA ligation involved in DNA repair	XRCC4	IDA		Human	PMID:17290226
Biological Process	GO:0051103	DNA ligation involved in DNA repair	XRCC4	IDA		Human	PMID:28453785
Biological Process	GO:0006302	double-strand break repair	XRCC4	IDA		Human	PMID:9242410
Biological Process	GO:0006302	double-strand break repair	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:11751629
Biological Process	GO:0006302	double-strand break repair	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC4	IDA		Human	PMID:12517771
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC4	IDA		Human	PMID:15385968
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC4	IDA		Human	PMID:17290226
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC4	IDA		Human	PMID:25597996
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC4	IMP		Human	PMID:25742519
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC4	IDA		Human	PMID:25934149
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC4	IDA		Human	PMID:26774286
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC4	IDA		Human	PMID:27437582
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC4	IDA		Human	PMID:28500754
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC4	IMP	UniProtKB:P49917	Human	PMID:9809069
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Xrcc4	IMP		Mouse	MGI:MGI:3758502|PMID:14690602
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Xrcc4	IMP	MGI:MGI:1926771,MGI:MGI:3047571,MGI:MGI:3641440	Mouse	PMID:17713479
Biological Process	GO:0048144	fibroblast proliferation	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:0001701	in utero embryonic development	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:0045190	isotype switching	Xrcc4	IMP	MGI:MGI:1926771,MGI:MGI:3047571,MGI:MGI:3641440	Mouse	PMID:17713479
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:1905765	negative regulation of protection from non-homologous end joining at telomere	Xrcc4	IMP		Mouse	MGI:MGI:3758502|PMID:14690602
Biological Process	GO:0022008	neurogenesis	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:0051402	neuron apoptotic process	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:0051351	positive regulation of ligase activity	XRCC4	IDA		Human	PMID:9242410
Biological Process	GO:0050769	positive regulation of neurogenesis	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:0002328	pro-B cell differentiation	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:1990166	protein localization to site of double-strand break	XRCC4	IDA		Human	PMID:31548606
Biological Process	GO:0010332	response to gamma radiation	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:0010212	response to ionizing radiation	Xrcc4	IMP	MGI:MGI:1926771,MGI:MGI:3047571,MGI:MGI:3641440	Mouse	PMID:17713479
Biological Process	GO:0010165	response to X-ray	XRCC4	IDA		Human	PMID:9242410
Biological Process	GO:0010165	response to X-ray	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:9875844
Biological Process	GO:0061819	telomeric DNA-containing double minutes formation	Xrcc4	IMP		Mouse	MGI:MGI:3758502|PMID:14690602
Biological Process	GO:0033151	V(D)J recombination	Xrcc4	IMP	MGI:MGI:1926771	Mouse	PMID:10716994

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern