| GO term: | site of double-strand break |
| Synonym: | DNA damage foci |
| Synonym: | DNA damage focus |
| Synonym: | ionizing radiation-induced foci |
| Synonym: | IRIF |
| Synonym: | site of DSB |
| GO id: | GO:0035861 |
| Definition: | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
| Number of paths to term: | 17 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
cellular_componentcellcell partintracellularintracellular partintracellular organelleintracellular non-membrane-bounded organellechromosomechromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentcellcell partintracellularintracellular partintracellular organelleintracellular organelle partchromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentcellcell partintracellularintracellular partintracellular organelle partchromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentcellcell partintracellular partintracellular organelleintracellular non-membrane-bounded organellechromosomechromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentcellcell partintracellular partintracellular organelleintracellular organelle partchromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentcellcell partintracellular partintracellular organelle partchromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentcell partintracellularintracellular partintracellular organelleintracellular non-membrane-bounded organellechromosomechromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentcell partintracellularintracellular partintracellular organelleintracellular organelle partchromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentcell partintracellularintracellular partintracellular organelle partchromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentcell partintracellular partintracellular organelleintracellular non-membrane-bounded organellechromosomechromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentcell partintracellular partintracellular organelleintracellular organelle partchromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentcell partintracellular partintracellular organelle partchromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentorganelleintracellular organelleintracellular non-membrane-bounded organellechromosomechromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentorganelleintracellular organelleintracellular organelle partchromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentorganellenon-membrane-bounded organelleintracellular non-membrane-bounded organellechromosomechromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentorganelleorganelle partintracellular organelle partchromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexcellular_componentorganelle partintracellular organelle partchromosomal partCBF3 complexchromatin +chromocenter +chromosome, centromeric core regionchromosome, centromeric outer repeat regionchromosome, centromeric region +chromosome, telomeric region +cohesin complex +cohesin core heterodimercondensed chromosome inner kinetochore +condensed chromosome outer kinetochore +condensin complex +condensin core heterodimerCtf18 RFC-like complexDNA replication factor C complex +DNA replication termination regiondosage compensation complex +Elg1 RFC-like complexHULC complexkinetochore +Lsd1/2 complexMIS12/MIND type complex +Mis6-Sim4 complexmonopolin complexMyb complexNdc80 complexNMS complexnuclear chromosome part +nucleosome +origin recognition complex +polytene chromosome bandpolytene chromosome ectopic fiberpolytene chromosome interbandpolytene chromosome puffpolytene chromosome weak pointprovirusRad17 RFC-like complexRecFOR complexRecQ helicase-Topo III complexreplication fork +replication inhibiting complex +replisome +site of double-strand break [GO:0035861] (5 genes, 5 annotations)Smc5-Smc6 complextelomere cap complex +telomere-telomerase complexMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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