Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Wnk1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes WNK1
- Mouse genes Wnk1
- Rat genes Wnk1
- Zfish genes wnk1a,wnk1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wnk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	WNK1	IDA		Human	PMID:10660600
Molecular Function	GO:0005524	ATP binding	Wnk1	IDA		Rat	PMID:10828064\|RGD:633747
Molecular Function	GO:0005524	ATP binding	Wnk1	IDA		Rat	PMID:15081430\|RGD:2298791
Molecular Function	GO:0019869	chloride channel inhibitor activity	WNK1	IDA		Human	PMID:17673510
Molecular Function	GO:0000287	magnesium ion binding	Wnk1	IMP		Rat	PMID:10828064\|RGD:633747
Molecular Function	GO:0019902	phosphatase binding	WNK1	IDA		Human	PMID:19389623
Molecular Function	GO:0019870	potassium channel inhibitor activity	Wnk1	IDA		Rat	PMID:16775035\|RGD:2298792
Molecular Function	GO:0005515	protein binding	WNK1	IPI	UniProtKB:P29101	Human	PMID:15350218
Molecular Function	GO:0005515	protein binding	WNK1	IPI	UniProtKB:O95747	Human	PMID:16832045
Molecular Function	GO:0005515	protein binding	WNK1	IPI	UniProtKB:O95747	Human	PMID:17721439
Molecular Function	GO:0005515	protein binding	WNK1	IPI	UniProtKB:P62136	Human	PMID:19389623
Molecular Function	GO:0005515	protein binding	WNK1	IPI	UniProtKB:O95747	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	WNK1	IPI	UniProtKB:Q93009	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Wnk1	IPI	UniProtKB:E0CZ16	Mouse	PMID:23576762
Molecular Function	GO:0005515	protein binding	Wnk1	IPI	UniProtKB:E0CZ16	Mouse	PMID:24821705
Molecular Function	GO:0005515	protein binding	Wnk1	IPI	PR:P46096	Mouse	PMID:15350218
Molecular Function	GO:0005515	protein binding	Wnk1	IPI	PR:O35681	Mouse	PMID:15350218
Molecular Function	GO:0005515	protein binding	Wnk1	IPI	PR:Q9R0N9	Mouse	PMID:15350218
Molecular Function	GO:0005515	protein binding	Wnk1	IPI	PR:P46097	Mouse	PMID:15350218
Molecular Function	GO:0005515	protein binding	Wnk1	IPI	UniProtKB:P29101	Rat	PMID:15350218\|RGD:8553276
Molecular Function	GO:0005515	protein binding	Wnk1	IPI	RGD:1310466	Rat	PMID:16083423\|RGD:1624357
Molecular Function	GO:0005515	protein binding	Wnk1	IPI	UniProtKB:Q9JIH7	Rat	PMID:16204408\|RGD:11535105
Molecular Function	GO:0005515	protein binding	Wnk1	IPI	UniProtKB:Q9JIH7-5	Rat	PMID:16204408\|RGD:11535105
Molecular Function	GO:0030295	protein kinase activator activity	WNK1	IMP		Human	PMID:16669787
Molecular Function	GO:0004672	protein kinase activity	WNK1	IMP		Human	PMID:16669787
Molecular Function	GO:0004672	protein kinase activity	Wnk1	IDA		Mouse	PMID:15350218
Molecular Function	GO:0019901	protein kinase binding	WNK1	IPI	UniProtKB:O95747	Human	PMID:16669787
Molecular Function	GO:0019901	protein kinase binding	Wnk1	IPI	RGD:621643	Rat	PMID:16083423\|RGD:1624357
Molecular Function	GO:0004674	protein serine/threonine kinase activity	WNK1	IDA		Human	PMID:10660600
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Wnk1	IMP		Mouse	MGI:MGI:6141968\|PMID:27400149
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Wnk1	IDA		Rat	PMID:10828064\|RGD:633747
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Wnk1	IDA		Rat	PMID:15081430\|RGD:2298791
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Wnk1	IDA		Rat	PMID:24803536\|RGD:12910999
Molecular Function	GO:0030291	protein serine/threonine kinase inhibitor activity	Wnk1	IDA		Rat	PMID:15081430\|RGD:2298791
Cellular Component	GO:0005737	cytoplasm	WNK1	IDA		Human	PMID:10660600
Cellular Component	GO:0005737	cytoplasm	Wnk1	IDA		Mouse	MGI:MGI:3690170\|PMID:11498583
Cellular Component	GO:0005737	cytoplasm	Wnk1	IDA		Rat	PMID:10828064\|RGD:633747
Cellular Component	GO:0005829	cytosol	WNK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Wnk1	IDA		Rat	PMID:25515571\|RGD:11535087
Cellular Component	GO:0098982	GABA-ergic synapse	Wnk1	EXP		Rat	PMID:26126716\|RGD:11053831
Cellular Component	GO:0098982	GABA-ergic synapse	Wnk1	IDA		Rat	PMID:26126716\|RGD:11053831
Cellular Component	GO:0098982	GABA-ergic synapse	Wnk1	IMP		Rat	PMID:26126716\|RGD:11053831
Cellular Component	GO:0016020	membrane	Wnk1	IDA		Rat	PMID:25515571\|RGD:11535087
Cellular Component	GO:0032991	protein-containing complex	Wnk1	IDA		Mouse	PMID:25113964
Biological Process	GO:0001525	angiogenesis	wnk1b	IMP	ZFIN:ZDB-MRPHLNO-141209-3	Zfish	PMID:25171174
Biological Process	GO:0001525	angiogenesis	wnk1a	IMP	ZFIN:ZDB-MRPHLNO-141209-2	Zfish	PMID:25171174
Biological Process	GO:0001525	angiogenesis	wnk1a	IMP	ZFIN:ZDB-MRPHLNO-141209-1	Zfish	PMID:25171174
Biological Process	GO:0071277	cellular response to calcium ion	Wnk1	IDA		Rat	PMID:24803536\|RGD:12910999
Biological Process	GO:1990869	cellular response to chemokine	WNK1	IMP		Human	PMID:27400149
Biological Process	GO:1990869	cellular response to chemokine	Wnk1	IMP		Mouse	MGI:MGI:6141968\|PMID:27400149
Biological Process	GO:0038116	chemokine (C-C motif) ligand 21 signaling pathway	Wnk1	IMP		Mouse	MGI:MGI:6141968\|PMID:27400149
Biological Process	GO:0030644	intracellular chloride ion homeostasis	Wnk1	IGI	MGI:MGI:1858416	Mouse	PMID:29459793
Biological Process	GO:0035556	intracellular signal transduction	WNK1	IDA		Human	PMID:10660600
Biological Process	GO:0035556	intracellular signal transduction	Wnk1	IDA		Rat	PMID:10828064\|RGD:633747
Biological Process	GO:0097022	lymphocyte migration into lymph node	Wnk1	IMP		Mouse	MGI:MGI:6141968\|PMID:27400149
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Wnk1	EXP		Rat	PMID:26126716\|RGD:11053831
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Wnk1	IDA		Rat	PMID:26126716\|RGD:11053831
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Wnk1	IMP		Rat	PMID:26126716\|RGD:11053831
Biological Process	GO:0055080	monoatomic cation homeostasis	Wnk1	IDA		Mouse	MGI:MGI:2669773\|PMID:12671053
Biological Process	GO:0006811	monoatomic ion transport	Wnk1	IDA		Mouse	MGI:MGI:2669773\|PMID:12671053
Biological Process	GO:0033633	negative regulation of cell-cell adhesion mediated by integrin	WNK1	IMP		Human	PMID:27400149
Biological Process	GO:0034260	negative regulation of GTPase activity	WNK1	IMP		Human	PMID:27400149
Biological Process	GO:0034260	negative regulation of GTPase activity	Wnk1	IMP		Mouse	MGI:MGI:6141968\|PMID:27400149
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	WNK1	IMP		Human	PMID:27400149
Biological Process	GO:0033673	negative regulation of kinase activity	Wnk1	IDA		Rat	PMID:15081430\|RGD:2298791
Biological Process	GO:1903038	negative regulation of leukocyte cell-cell adhesion	WNK1	IMP		Human	PMID:27400149
Biological Process	GO:0090188	negative regulation of pancreatic juice secretion	Wnk1	IMP		Mouse	PMID:21317537
Biological Process	GO:0010766	negative regulation of sodium ion transport	Wnk1	IDA		Rat	PMID:16204408\|RGD:11535105
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Wnk1	IMP		Mouse	MGI:MGI:6141968\|PMID:27400149
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	WNK1	IMP		Human	PMID:27782176
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Wnk1	IMP		Mouse	MGI:MGI:6221361\|PMID:27782176
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	WNK1	IMP		Human	PMID:23797875
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	Wnk1	IMP	MGI:MGI:2683145	Mouse	PMID:14610273
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	WNK1	IMP		Human	PMID:27400149
Biological Process	GO:0048919	posterior lateral line neuromast development	wnk1b	IMP	ZFIN:ZDB-MRPHLNO-130220-5	Zfish	PMID:23300475
Biological Process	GO:0048919	posterior lateral line neuromast development	wnk1b	IGI	ZFIN:ZDB-MRPHLNO-110929-6,ZFIN:ZDB-MRPHLNO-130220-5	Zfish	PMID:23300475
Biological Process	GO:0055075	potassium ion homeostasis	Wnk1	IMP	MGI:MGI:5544571	Mouse	PMID:25113964
Biological Process	GO:0046777	protein autophosphorylation	Wnk1	IDA		Rat	PMID:10828064\|RGD:633747
Biological Process	GO:0046777	protein autophosphorylation	Wnk1	IDA		Rat	PMID:15081430\|RGD:2298791
Biological Process	GO:0006468	protein phosphorylation	WNK1	IDA		Human	PMID:10660600
Biological Process	GO:0006468	protein phosphorylation	WNK1	IMP		Human	PMID:16669787
Biological Process	GO:0006468	protein phosphorylation	Wnk1	IDA		Mouse	PMID:15350218
Biological Process	GO:0006468	protein phosphorylation	Wnk1	IDA		Rat	PMID:10828064\|RGD:633747
Biological Process	GO:0006468	protein phosphorylation	Wnk1	IDA		Rat	PMID:15081430\|RGD:2298791
Biological Process	GO:0006468	protein phosphorylation	Wnk1	IDA		Rat	PMID:24803536\|RGD:12910999
Biological Process	GO:0008217	regulation of blood pressure	Wnk1	IMP	MGI:MGI:5544571	Mouse	PMID:25113964
Biological Process	GO:1904062	regulation of monoatomic cation transmembrane transport	WNK1	IMP		Human	PMID:27782176
Biological Process	GO:1902305	regulation of sodium ion transmembrane transport	Wnk1	IMP	MGI:MGI:5544571	Mouse	PMID:25113964
Biological Process	GO:0002028	regulation of sodium ion transport	Wnk1	IDA		Rat	PMID:16204408\|RGD:11535105
Biological Process	GO:0007165	signal transduction	WNK1	IDA		Human	PMID:16669787
Biological Process	GO:0035725	sodium ion transmembrane transport	Wnk1	IMP	MGI:MGI:5544571	Mouse	PMID:25113964
Biological Process	GO:0050852	T cell receptor signaling pathway	Wnk1	IMP		Mouse	MGI:MGI:6141968\|PMID:27400149

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.