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Wnk1 Gene Detail
Summary
  • Symbol
    Wnk1
  • Name
    WNK lysine deficient protein kinase 1
  • Synonyms
    6430573H23Rik, EG406236, Hsn2, Prkwnk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442092
    NCBI Gene: 232341
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:119900930-120015633 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 56.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1923 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442092
 protein coding gene Chr6:119900930-120015659 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031198
 protein coding gene Chr6:122766553-122903583 (-)
A/J MGP_AJ_G0031167
 protein coding gene Chr6:118059184-118173240 (-)
AKR/J MGP_AKRJ_G0031098
 protein coding gene Chr6:121230401-121348739 (-)
BALB/cJ MGP_BALBcJ_G0031178
 protein coding gene Chr6:117825646-117947537 (-)
C3H/HeJ MGP_C3HHeJ_G0030531
 protein coding gene Chr6:62955346-63081047 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031636
 protein coding gene Chr6:125899156-126026445 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028797
 protein coding gene Chr6:114959577-115080821 (-)
CAST/EiJ MGP_CASTEiJ_G0030285
 protein coding gene Chr6:121674144-121796508 (-)
CBA/J MGP_CBAJ_G0030861
 protein coding gene Chr6:130898455-131037296 (-)
DBA/2J MGP_DBA2J_G0031017
 protein coding gene Chr6:116953510-117071500 (-)
FVB/NJ MGP_FVBNJ_G0030969
 protein coding gene Chr6:116072714-116188611 (-)
LP/J MGP_LPJ_G0031096
 protein coding gene Chr6:122765819-122886385 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031003
 protein coding gene Chr6:134881342-135038788 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031665
 protein coding gene Chr6:121265676-121385400 (-)
PWK/PhJ MGP_PWKPhJ_G0030000
 protein coding gene Chr6:115979234-116097596 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029829
 protein coding gene Chr6:119994738-120114279 (-)
WSB/EiJ MGP_WSBEiJ_G0030368
 protein coding gene Chr6:121546516-121668578 (-)



Homology
more
  • Human Ortholog
    WNK1, WNK lysine deficient protein kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNK1, WNK lysine deficient protein kinase 1
  • Synonyms
    HSAN2, HSN2, KDP, p65, PPP1R167, PRKWNK1, PSK
  • Links
    NCBI Gene ID: 65125
    UniProt: Q9H4A3

  • Chr Location
    12p13.33; chr12:752579-911452 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human WNK1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 6 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die before birth, whereas heterozygotes survive and exhibit decreased blood pressure. Mice homozygous for an allele that does not produce the kidney isoform exhibit a slight increase in systemic arterial diastolic blood pressure and reduced sensitivity to amiloride.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    157
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1133
  • Tissues
    211
  • cDNA Data
    313
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045962 Ensembl Gene Model | MGI Sequence Detail 114704 C57BL/6J ±  kb
    transcript ENSMUST00000088644 Ensembl | MGI Sequence Detail 11330 Not Applicable  
    polypeptide ENSMUSP00000086017 Ensembl | MGI Sequence Detail 2635 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      16 Sequences
    • Protein Ontology
      PR:000017431 serine/threonine-protein kinase WNK1
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
      IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
      IPR050588 With No Lysine (K) Ser/Thr Protein Kinase
    • GlyGen
      P83741 35 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (31 sites)
    Molecular
    Reagents
    less
    • All nucleic 317
      cDNA 313
      Primer pair 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:3644010
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 17
      Gene Ontology 22
      Phenotypes 32
    • Earliest
      J:114792 Wilson FH, et al., Human hypertension caused by mutations in WNK kinases. Science. 2001 Aug 10;293(5532):1107-12
    • Latest
      J:367388 Trzeciak AJ, et al., WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity. Nat Commun. 2025 May 28;16(1):4945
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory