Wnk1
Gene Detail

Symbol Name ID

Wnk1 WNK lysine deficient protein kinase 1 MGI:2442092

Synonyms

6430573H23Rik, EG406236, Hsn2, Prkwnk1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

56.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:119923969-120038672 bp, - strand From VEGA annotation of GRCm38   114704 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14253  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Wnk1

Human homologs

Human Homolog		WNK1, WNK lysine deficient protein kinase 1
NCBI Gene ID		65125
neXtProt AC		NX_Q9H4A3
Human Synonyms		HSAN2, HSN2, KDP, p65, PRKWNK1, PSK
Human Chr (Location)		12p13.3; chr12:752593-911452 (+)  GRCh38
Disease Associations		(2) Diseases Associated with Human WNK1

Alleles and phenotypes

All alleles(38) : Targeted(4) Gene trapped(34)
 

Homozygous mutant mice die before birth, whereas heterozygotes survive and exhibit decreased blood pressure. Mice homozygous for an allele that does not produce the kidney isoform exhibit a slight increase in systemic arterial diastolic blood pressure and reduced sensitivity to amiloride.

 
Human Diseases Modeled Using Mouse Wnk1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	intracellular signal transduction, ion transport, ...
Component	cytoplasm
Function	ATP binding, chloride channel inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)

Data Summary: Results (248)    Tissues (150)    Images (59)
Theiler Stages: 19, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	248

cDNA source data(309)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(310) cDNA(309) Primer pair(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000031633 (Evidence)
Ensembl Gene Model	ENSMUSG00000045962 (Evidence)
Entrez Gene	232341 (Evidence)
UniGene	333349
DFCI	TC1571910, TC1587234, TC1599371, TC1601629, TC1602938, TC1640714, TC1645568
DoTS	DT.101149911, DT.101270008, DT.102557034, DT.110487211, DT.110487245, DT.532359, DT.91592618, DT.94159817, DT.94369252
NIA Mouse Gene Index	U042765
EC	2.7.11.1
Consensus CDS Project	CCDS20478.1, CCDS51888.1, CCDS57444.1, CCDS57445.1
International Mouse Knockout Project Status	Wnk1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031633	VEGA Gene Model | MGI Sequence Detail	114704	C57BL/6J
transcript	OTTMUST00000078356	VEGA | MGI Sequence Detail	10575	Not Applicable
polypeptide	OTTMUSP00000041662	VEGA | MGI Sequence Detail	2377	Not Applicable

All sequences(161) RefSeq(21) UniProt(16)

Polymorphisms

SNPs within 2kb(254 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR024678	Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology	PR:000017431	serine/threonine-protein kinase WNK1

References

(Earliest) J:114792 Wilson FH, et al., Human hypertension caused by mutations in WNK kinases. Science. 2001 Aug 10;293(5532):1107-12
(Latest) J:200742 Vidal-Petiot E, et al., WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14366-71
All references(56)

Other accession IDs

MGI:3644010