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Wnk1
Gene Detail
Symbol

Name
ID
Wnk1
WNK lysine deficient protein kinase 1
MGI:2442092
Synonyms
6430573H23Rik, EG406236, Hsn2, Prkwnk1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
56.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:119923969-120038672 bp, - strand
From VEGA annotation of GRCm38

  114704 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14253  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Gene Tree: Wnk1

Human
homologs
Human Homolog WNK1, WNK lysine deficient protein kinase 1
NCBI Gene ID 65125
neXtProt AC  NX_Q9H4A3
Human Synonyms  HSAN2, HSN2, KDP, p65, PPP1R167, PRKWNK1, PSK
Human Chr (Location)  12p13.3; chr12:752593-911452 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human WNK1
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(34) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice die before birth, whereas heterozygotes survive and exhibit decreased blood pressure. Mice homozygous for an allele that does not produce the kidney isoform exhibit a slight increase in systemic arterial diastolic blood pressure and reduced sensitivity to amiloride.
 
Human Diseases Modeled Using Mouse Wnk1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Wnk1 interacts with 419 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process intracellular signal transduction, ion transport, ...
Component cytoplasm
Function ATP binding, chloride channel inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (248)    Tissues (150)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 248
cDNA source data(309)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(310) cDNA(309) Primer pair(1)
Microarray probesets(8)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031633 VEGA Gene Model | MGI Sequence Detail 114704 C57BL/6J ±  kb
transcript OTTMUST00000078356 VEGA | MGI Sequence Detail 10575 Not Applicable 
polypeptide OTTMUSP00000041662 VEGA | MGI Sequence Detail 2377 Not Applicable 

For the selected sequences
All sequences(176) RefSeq(21) UniProt(31)
Polymorphisms
SNPs within 2kb(254 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology PR:000017431 serine/threonine-protein kinase WNK1
References
(Earliest) J:114792 Wilson FH, et al., Human hypertension caused by mutations in WNK kinases. Science. 2001 Aug 10;293(5532):1107-12
(Latest) J:200742 Vidal-Petiot E, et al., WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14366-71
All references(57)
Disease annotation references (1)
Other
accession IDs
MGI:3644010

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory