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Wnk1 Gene Detail
Summary
  • Symbol
    Wnk1
  • Name
    WNK lysine deficient protein kinase 1
  • Synonyms
    6430573H23Rik, EG406236, Hsn2, Prkwnk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442092
    NCBI Gene: 232341
  • Gene Overview
    MyGene.info: WNK1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr6:119923969-120038672 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      114704 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 56.86 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    WNK1, WNK lysine deficient protein kinase 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    WNK1, WNK lysine deficient protein kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSAN2, HSN2, KDP, p65, PPP1R167, PRKWNK1, PSK
  • Links
    NCBI Gene ID: 65125
    neXtProt AC: NX_Q9H4A3
    UniProt: Q9H4A3

  • Chr Location
    12p13.33; chr12:752552-911452 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human WNK1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 6 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice die before birth, whereas heterozygotes survive and exhibit decreased blood pressure. Mice homozygous for an allele that does not produce the kidney isoform exhibit a slight increase in systemic arterial diastolic blood pressure and reduced sensitivity to amiloride.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    55
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    417
  • Tissues
    208
  • cDNA Data
    312
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031633 VEGA Gene Model | MGI Sequence Detail 114704 C57BL/6J ±  kb
    transcript OTTMUST00000078356 VEGA | MGI Sequence Detail 10575 Not Applicable  
    polypeptide OTTMUSP00000041662 VEGA | MGI Sequence Detail 2377 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      252 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 316
      cDNA 312
      Primer pair 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:3644010
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:114792 Wilson FH, et al., Human hypertension caused by mutations in WNK kinases. Science. 2001 Aug 10;293(5532):1107-12
    • Latest
      J:263369 Rafael C, et al., Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4. Sci Rep. 2018 Feb 19;8(1):3249
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory