Wnk1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Wnk1
WNK lysine deficient protein kinase 1
MGI:2442092

50 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Cdh16-Wnk1*)#Cihu/0 involves: C57BL/6	decreased circulating potassium level	J:168700
	decreased systemic arterial diastolic blood pressure	J:168700
	decreased systemic arterial systolic blood pressure	J:168700
	increased circulating aldosterone level	J:168700
	increased circulating angiotensinogen level	J:168700
	increased urine potassium level	J:168700
	increased urine sodium level	J:168700
Wnk1^{Gt(OST38262)Lex}/Wnk1⁺ involves: 129S5/SvEvBrd * C57BL/6J	decreased systemic arterial blood pressure	J:86696
	normal homeostasis/metabolism phenotype	J:86696
Wnk1^{Gt(OST38262)Lex}/Wnk1^{Gt(OST38262)Lex} involves: 129S5/SvEvBrd	abnormal angiogenesis	J:152906
	abnormal blood vessel morphology	J:152906
	abnormal brain vasculature morphology	J:152906
	abnormal cardinal vein morphology	J:152906
	abnormal dorsal aorta morphology	J:152906
	abnormal myocardial trabeculae morphology	J:152906
	abnormal placenta labyrinth morphology	J:152906
	abnormal placental labyrinth vasculature morphology	J:152906
	abnormal vascular branching morphogenesis	J:152906
	abnormal visceral yolk sac morphology	J:152906
	abnormal vitelline vascular remodeling	J:152906
	abnormal vitelline vasculature morphology	J:152906
	distended pericardium	J:152906
	embryonic growth retardation	J:152906
	embryonic lethality during organogenesis, complete penetrance	J:152906
	heart hemorrhage	J:152906
	heart hypoplasia	J:152906
	hemorrhage	J:152906
	internal hemorrhage	J:152906
	intracranial hemorrhage	J:152906
	pale yolk sac	J:152906
	pericardial edema	J:152906
	thin myocardium	J:152906
	trabecula carnea hypoplasia	J:152906
Wnk1^{Gt(OST38262)Lex}/Wnk1^{Gt(OST38262)Lex} involves: 129S5/SvEvBrd * C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:86696
Wnk1^tm1.1Juha/Wnk1^tm1.1Juha involves: 129S2/SvPas * C57BL/6 * C57BL/6N * SJL	abnormal urine homeostasis	J:165537
	decreased physiological sensitivity to xenobiotic	J:165537
	increased mean systemic arterial blood pressure	J:165537
	increased systemic arterial diastolic blood pressure	J:165537
	oliguria	J:165537
Wnk1^tm1Clhu/Wnk1^tm1Clhu Tg(Tek-cre)12Flv/0 involves: C3H * C57BL/6	abnormal brain vasculature morphology	J:152906
	abnormal cardinal vein morphology	J:152906
	abnormal dorsal aorta morphology	J:152906
	abnormal myocardial trabeculae morphology	J:152906
	abnormal vascular branching morphogenesis	J:152906
	abnormal vitelline vascular remodeling	J:152906
	abnormal vitelline vasculature morphology	J:152906
	decreased embryo size	J:152906
	embryonic lethality during organogenesis, complete penetrance	J:152906
	heart hypoplasia	J:152906
	pericardial edema	J:152906
	thin myocardium	J:152906
Wnk1^tm2.1Juha/Wnk1⁺ Tg(Pgk1-cre)1Lni/0 involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL	abnormal distal convoluted tubule morphology	J:200742
	abnormal kidney physiology	J:200742
	decreased hematocrit	J:200742
	normal homeostasis/metabolism phenotype	J:200742
	hyperkalemia	J:200742
	increased circulating chloride level	J:200742
	increased systemic arterial systolic blood pressure	J:200742
	increased urine aldosterone level	J:200742
	increased urine calcium level	J:200742
	metabolic acidosis	J:200742
Wnk1^tm2Cihu/Wnk1^tm2Cihu 129-Wnk1^tm2Cihu	decreased urine sodium level	J:168700
	increased circulating sodium level	J:168700
	increased systemic arterial systolic blood pressure	J:168700

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23