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Gene Ontology Browser
Term Detail
GO term:negative regulation of GTPase activity
Synonym: down regulation of GTPase activity
Synonym: down-regulation of GTPase activity
Synonym: downregulation of GTPase activity
Synonym: inhibition of GTPase activity
Synonym: negative regulation of guanosinetriphosphatase activity
GO id:GO:0034260
Definition:Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
Number of paths to term: 20

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-anegative regulation of biological process
                                        is-anegative regulation of metabolic process
                                                is-anegative regulation of catalytic activity
                                                        is-anegative regulation of hydrolase activity
                                                                is-anegative regulation of ATPase activity +
                                                                is-anegative regulation of beta-galactosidase activity
                                                                is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                                is-anegative regulation of DNA N-glycosylase activity
                                                                is-anegative regulation of dUTP diphosphatase activity
                                                                is-anegative regulation of endo-1,4-beta-xylanase activity
                                                                is-anegative regulation of exo-alpha-sialidase activity +
                                                                is-anegative regulation of GTP cyclohydrolase I activity
                                                                is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                        is-anegative regulation of Ras GTPase activity +
                                                                is-anegative regulation of helicase activity +
                                                                is-anegative regulation of histone deacetylase activity
                                                                is-anegative regulation of lipase activity +
                                                                is-anegative regulation of lysozyme activity
                                                                is-anegative regulation of microtubule motor activity +
                                                                is-anegative regulation of nuclease activity +
                                                                is-anegative regulation of peptidase activity +
                                                                is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-anegative regulation of metabolic process
                                                is-anegative regulation of catalytic activity
                                                        is-anegative regulation of hydrolase activity
                                                                is-anegative regulation of ATPase activity +
                                                                is-anegative regulation of beta-galactosidase activity
                                                                is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                                is-anegative regulation of DNA N-glycosylase activity
                                                                is-anegative regulation of dUTP diphosphatase activity
                                                                is-anegative regulation of endo-1,4-beta-xylanase activity
                                                                is-anegative regulation of exo-alpha-sialidase activity +
                                                                is-anegative regulation of GTP cyclohydrolase I activity
                                                                is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                        is-anegative regulation of Ras GTPase activity +
                                                                is-anegative regulation of helicase activity +
                                                                is-anegative regulation of histone deacetylase activity
                                                                is-anegative regulation of lipase activity +
                                                                is-anegative regulation of lysozyme activity
                                                                is-anegative regulation of microtubule motor activity +
                                                                is-anegative regulation of nuclease activity +
                                                                is-anegative regulation of peptidase activity +
                                                                is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of catalytic activity
                                                is-anegative regulation of catalytic activity
                                                        is-anegative regulation of hydrolase activity
                                                                is-anegative regulation of ATPase activity +
                                                                is-anegative regulation of beta-galactosidase activity
                                                                is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                                is-anegative regulation of DNA N-glycosylase activity
                                                                is-anegative regulation of dUTP diphosphatase activity
                                                                is-anegative regulation of endo-1,4-beta-xylanase activity
                                                                is-anegative regulation of exo-alpha-sialidase activity +
                                                                is-anegative regulation of GTP cyclohydrolase I activity
                                                                is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                        is-anegative regulation of Ras GTPase activity +
                                                                is-anegative regulation of helicase activity +
                                                                is-anegative regulation of histone deacetylase activity
                                                                is-anegative regulation of lipase activity +
                                                                is-anegative regulation of lysozyme activity
                                                                is-anegative regulation of microtubule motor activity +
                                                                is-anegative regulation of nuclease activity +
                                                                is-anegative regulation of peptidase activity +
                                                                is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of catalytic activity
                                                is-aregulation of hydrolase activity
                                                        is-anegative regulation of hydrolase activity
                                                                is-anegative regulation of ATPase activity +
                                                                is-anegative regulation of beta-galactosidase activity
                                                                is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                                is-anegative regulation of DNA N-glycosylase activity
                                                                is-anegative regulation of dUTP diphosphatase activity
                                                                is-anegative regulation of endo-1,4-beta-xylanase activity
                                                                is-anegative regulation of exo-alpha-sialidase activity +
                                                                is-anegative regulation of GTP cyclohydrolase I activity
                                                                is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                        is-anegative regulation of Ras GTPase activity +
                                                                is-anegative regulation of helicase activity +
                                                                is-anegative regulation of histone deacetylase activity
                                                                is-anegative regulation of lipase activity +
                                                                is-anegative regulation of lysozyme activity
                                                                is-anegative regulation of microtubule motor activity +
                                                                is-anegative regulation of nuclease activity +
                                                                is-anegative regulation of peptidase activity +
                                                                is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of catalytic activity
                                                is-aregulation of hydrolase activity
                                                        is-aregulation of GTPase activity
                                                                is-aheterotrimeric G-protein complex cycle
                                                                is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                        is-anegative regulation of Ras GTPase activity +
                                                                is-apositive regulation of GTPase activity +
                                                                is-aregulation of Ras GTPase activity +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of molecular function
                                is-anegative regulation of molecular function
                                        is-anegative regulation of catalytic activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of molecular function
                                is-aregulation of catalytic activity
                                        is-anegative regulation of catalytic activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of molecular function
                                is-aregulation of catalytic activity
                                        is-aregulation of hydrolase activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of molecular function
                                is-aregulation of catalytic activity
                                        is-aregulation of hydrolase activity
                                                is-aregulation of GTPase activity
                                                        is-aheterotrimeric G-protein complex cycle
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-apositive regulation of GTPase activity +
                                                        is-aregulation of Ras GTPase activity +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        negatively-regulatesnegative regulation of metabolic process
                                is-anegative regulation of catalytic activity
                                        is-anegative regulation of hydrolase activity
                                                is-anegative regulation of ATPase activity +
                                                is-anegative regulation of beta-galactosidase activity
                                                is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                is-anegative regulation of DNA N-glycosylase activity
                                                is-anegative regulation of dUTP diphosphatase activity
                                                is-anegative regulation of endo-1,4-beta-xylanase activity
                                                is-anegative regulation of exo-alpha-sialidase activity +
                                                is-anegative regulation of GTP cyclohydrolase I activity
                                                is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                        is-anegative regulation of Ras GTPase activity +
                                                is-anegative regulation of helicase activity +
                                                is-anegative regulation of histone deacetylase activity
                                                is-anegative regulation of lipase activity +
                                                is-anegative regulation of lysozyme activity
                                                is-anegative regulation of microtubule motor activity +
                                                is-anegative regulation of nuclease activity +
                                                is-anegative regulation of peptidase activity +
                                                is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-anegative regulation of metabolic process
                                        is-anegative regulation of catalytic activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of catalytic activity
                                        is-anegative regulation of catalytic activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of catalytic activity
                                        is-aregulation of hydrolase activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of catalytic activity
                                        is-aregulation of hydrolase activity
                                                is-aregulation of GTPase activity
                                                        is-aheterotrimeric G-protein complex cycle
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-apositive regulation of GTPase activity +
                                                        is-aregulation of Ras GTPase activity +


Gene_Ontology
        is-abiological_process
                negatively-regulatesnegative regulation of biological process
                        is-anegative regulation of metabolic process
                                is-anegative regulation of catalytic activity
                                        is-anegative regulation of hydrolase activity
                                                is-anegative regulation of ATPase activity +
                                                is-anegative regulation of beta-galactosidase activity
                                                is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                is-anegative regulation of DNA N-glycosylase activity
                                                is-anegative regulation of dUTP diphosphatase activity
                                                is-anegative regulation of endo-1,4-beta-xylanase activity
                                                is-anegative regulation of exo-alpha-sialidase activity +
                                                is-anegative regulation of GTP cyclohydrolase I activity
                                                is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                        is-anegative regulation of Ras GTPase activity +
                                                is-anegative regulation of helicase activity +
                                                is-anegative regulation of histone deacetylase activity
                                                is-anegative regulation of lipase activity +
                                                is-anegative regulation of lysozyme activity
                                                is-anegative regulation of microtubule motor activity +
                                                is-anegative regulation of nuclease activity +
                                                is-anegative regulation of peptidase activity +
                                                is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-anegative regulation of biological process
                                is-anegative regulation of metabolic process
                                        is-anegative regulation of catalytic activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-anegative regulation of metabolic process
                                        is-anegative regulation of catalytic activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of catalytic activity
                                        is-anegative regulation of catalytic activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of catalytic activity
                                        is-aregulation of hydrolase activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of catalytic activity
                                        is-aregulation of hydrolase activity
                                                is-aregulation of GTPase activity
                                                        is-aheterotrimeric G-protein complex cycle
                                                        is-anegative regulation of GTPase activity [GO:0034260] (22 genes, 23 annotations)
                                                                is-anegative regulation of Ras GTPase activity +
                                                        is-apositive regulation of GTPase activity +
                                                        is-aregulation of Ras GTPase activity +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory