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Term Detail
GO term:negative regulation of GTPase activity
Synonym: down regulation of GTPase activity
Synonym: down-regulation of GTPase activity
Synonym: downregulation of GTPase activity
Synonym: down regulation of Rab GTPase activity
Synonym: down-regulation of Rab GTPase activity
Synonym: downregulation of Rab GTPase activity
Synonym: down regulation of Ras GTPase activity
Synonym: down-regulation of Ras GTPase activity
Synonym: downregulation of Ras GTPase activity
Synonym: down regulation of regulation of Ran GTPase activity
Synonym: down-regulation of regulation of Ran GTPase activity
Synonym: downregulation of regulation of Ran GTPase activity
Synonym: down regulation of Rho GTPase activity
Synonym: down-regulation of Rho GTPase activity
Synonym: downregulation of Rho GTPase activity
Synonym: inhibition of GTPase activity
Synonym: inhibition of Rab GTPase activity
Synonym: inhibition of Ras GTPase activity
Synonym: inhibition of regulation of Ran GTPase activity
Synonym: inhibition of Rho GTPase activity
Synonym: negative regulation of guanosinetriphosphatase activity
Synonym: negative regulation of Rab GTPase activity
Synonym: negative regulation of Ran GTPase activity
Synonym: negative regulation of Ras GTPase activity
Synonym: negative regulation of Rho GTPase activity
GO id:GO:0034260
Alternate id: GO:0034261, GO:1902264, GO:1902881, GO:0034259
Definition:Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
CommentsAn example of this is P2xA in Dictyostelium (UniProt symbol Q86JM7) in PMID:24335649.
Number of paths to term: 7

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-anegative regulation of biological process
                                is-anegative regulation of action potential +
                                is-anegative regulation of asexual reproduction +
                                is-anegative regulation of behavior +
                                is-anegative regulation of cell killing +
                                is-anegative regulation of cellular process +
                                is-anegative regulation of cellular protein localization +
                                is-anegative regulation of circadian rhythm +
                                is-anegative regulation of developmental pigmentation +
                                is-anegative regulation of developmental process +
                                is-anegative regulation of dosage compensation by inactivation of X chromosome
                                is-anegative regulation of establishment of macromolecular complex localization to telomere
                                is-anegative regulation of establishment of protein localization +
                                is-anegative regulation of establishment of RNA localization to telomere
                                is-anegative regulation of fibrinolysis
                                is-anegative regulation of growth +
                                is-anegative regulation of GTPase activity [GO:0034260] (27 genes, 29 annotations)
                                is-anegative regulation of guanyl-nucleotide exchange factor activity +
                                is-anegative regulation of hemostasis +
                                is-anegative regulation of homeostatic process +
                                is-anegative regulation of immune system process +
                                is-anegative regulation of intracellular mRNA localization +
                                is-anegative regulation of ligand-dependent nuclear receptor transcription coactivator activity
                                is-anegative regulation of lipid storage +
                                is-anegative regulation of locomotion +
                                is-anegative regulation of long term synaptic depression
                                is-anegative regulation of long-term synaptic potentiation
                                is-anegative regulation of membrane depolarization +
                                is-anegative regulation of membrane hyperpolarization
                                is-anegative regulation of metabolic process +
                                is-anegative regulation of mitotic telomere tethering at nuclear periphery
                                is-anegative regulation of multi-organism process +
                                is-anegative regulation of multicellular organismal process +
                                is-anegative regulation of nitrogen utilization
                                is-anegative regulation of phosphorus utilization
                                is-anegative regulation of proteasome-activating ATPase activity
                                is-anegative regulation of protein localization to cell-cell adherens junction
                                is-anegative regulation of receptor localization to synapse
                                is-anegative regulation of reproductive process +
                                is-anegative regulation of response to stimulus +
                                is-anegative regulation of ribonucleoprotein complex localization +
                                is-anegative regulation of RNA binding transcription factor activity
                                is-anegative regulation of sequence-specific DNA binding transcription factor activity +
                                is-anegative regulation of signaling +
                                is-anegative regulation of sulfur utilization
                                is-anegative regulation of telomerase RNA localization to Cajal body
                                is-anegative regulation of transport +


obsolete Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of molecular function
                                is-anegative regulation of molecular function
                                        is-anegative regulation of catalytic activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of glucosylceramidase activity
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (27 genes, 29 annotations)
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +
                                                        is-anegative regulation of plus-end directed microfilament motor activity


obsolete Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of molecular function
                                is-aregulation of catalytic activity
                                        is-anegative regulation of catalytic activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of glucosylceramidase activity
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (27 genes, 29 annotations)
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +
                                                        is-anegative regulation of plus-end directed microfilament motor activity


obsolete Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of molecular function
                                is-aregulation of catalytic activity
                                        is-aregulation of hydrolase activity
                                                is-anegative regulation of hydrolase activity
                                                        is-anegative regulation of ATPase activity +
                                                        is-anegative regulation of beta-galactosidase activity
                                                        is-anegative regulation of cyclic-nucleotide phosphodiesterase activity
                                                        is-anegative regulation of DNA N-glycosylase activity
                                                        is-anegative regulation of dUTP diphosphatase activity
                                                        is-anegative regulation of endo-1,4-beta-xylanase activity
                                                        is-anegative regulation of exo-alpha-sialidase activity +
                                                        is-anegative regulation of glucosylceramidase activity
                                                        is-anegative regulation of GTP cyclohydrolase I activity
                                                        is-anegative regulation of GTPase activity [GO:0034260] (27 genes, 29 annotations)
                                                        is-anegative regulation of helicase activity +
                                                        is-anegative regulation of histone deacetylase activity
                                                        is-anegative regulation of lipase activity +
                                                        is-anegative regulation of lysozyme activity
                                                        is-anegative regulation of microtubule motor activity +
                                                        is-anegative regulation of nuclease activity +
                                                        is-anegative regulation of peptidase activity +
                                                        is-anegative regulation of phosphatase activity +
                                                        is-anegative regulation of plus-end directed microfilament motor activity


obsolete Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of molecular function
                                is-aregulation of catalytic activity
                                        is-aregulation of hydrolase activity
                                                is-aregulation of GTPase activity
                                                        is-aheterotrimeric G-protein complex cycle
                                                        is-anegative regulation of GTPase activity [GO:0034260] (27 genes, 29 annotations)
                                                        is-apositive regulation of GTPase activity +
                                                        is-aregulation of guanyl-nucleotide exchange factor activity +


obsolete Gene_Ontology
        is-abiological_process
                negatively-regulatesnegative regulation of biological process
                        is-anegative regulation of action potential +
                        is-anegative regulation of asexual reproduction +
                        is-anegative regulation of behavior +
                        is-anegative regulation of cell killing +
                        is-anegative regulation of cellular process +
                        is-anegative regulation of cellular protein localization +
                        is-anegative regulation of circadian rhythm +
                        is-anegative regulation of developmental pigmentation +
                        is-anegative regulation of developmental process +
                        is-anegative regulation of dosage compensation by inactivation of X chromosome
                        is-anegative regulation of establishment of macromolecular complex localization to telomere
                        is-anegative regulation of establishment of protein localization +
                        is-anegative regulation of establishment of RNA localization to telomere
                        is-anegative regulation of fibrinolysis
                        is-anegative regulation of growth +
                        is-anegative regulation of GTPase activity [GO:0034260] (27 genes, 29 annotations)
                        is-anegative regulation of guanyl-nucleotide exchange factor activity +
                        is-anegative regulation of hemostasis +
                        is-anegative regulation of homeostatic process +
                        is-anegative regulation of immune system process +
                        is-anegative regulation of intracellular mRNA localization +
                        is-anegative regulation of ligand-dependent nuclear receptor transcription coactivator activity
                        is-anegative regulation of lipid storage +
                        is-anegative regulation of locomotion +
                        is-anegative regulation of long term synaptic depression
                        is-anegative regulation of long-term synaptic potentiation
                        is-anegative regulation of membrane depolarization +
                        is-anegative regulation of membrane hyperpolarization
                        is-anegative regulation of metabolic process +
                        is-anegative regulation of mitotic telomere tethering at nuclear periphery
                        is-anegative regulation of multi-organism process +
                        is-anegative regulation of multicellular organismal process +
                        is-anegative regulation of nitrogen utilization
                        is-anegative regulation of phosphorus utilization
                        is-anegative regulation of proteasome-activating ATPase activity
                        is-anegative regulation of protein localization to cell-cell adherens junction
                        is-anegative regulation of receptor localization to synapse
                        is-anegative regulation of reproductive process +
                        is-anegative regulation of response to stimulus +
                        is-anegative regulation of ribonucleoprotein complex localization +
                        is-anegative regulation of RNA binding transcription factor activity
                        is-anegative regulation of sequence-specific DNA binding transcription factor activity +
                        is-anegative regulation of signaling +
                        is-anegative regulation of sulfur utilization
                        is-anegative regulation of telomerase RNA localization to Cajal body
                        is-anegative regulation of transport +


obsolete Gene_Ontology
        is-abiological_process
                is-aregulation of biological process
                        is-anegative regulation of biological process
                                is-anegative regulation of action potential +
                                is-anegative regulation of asexual reproduction +
                                is-anegative regulation of behavior +
                                is-anegative regulation of cell killing +
                                is-anegative regulation of cellular process +
                                is-anegative regulation of cellular protein localization +
                                is-anegative regulation of circadian rhythm +
                                is-anegative regulation of developmental pigmentation +
                                is-anegative regulation of developmental process +
                                is-anegative regulation of dosage compensation by inactivation of X chromosome
                                is-anegative regulation of establishment of macromolecular complex localization to telomere
                                is-anegative regulation of establishment of protein localization +
                                is-anegative regulation of establishment of RNA localization to telomere
                                is-anegative regulation of fibrinolysis
                                is-anegative regulation of growth +
                                is-anegative regulation of GTPase activity [GO:0034260] (27 genes, 29 annotations)
                                is-anegative regulation of guanyl-nucleotide exchange factor activity +
                                is-anegative regulation of hemostasis +
                                is-anegative regulation of homeostatic process +
                                is-anegative regulation of immune system process +
                                is-anegative regulation of intracellular mRNA localization +
                                is-anegative regulation of ligand-dependent nuclear receptor transcription coactivator activity
                                is-anegative regulation of lipid storage +
                                is-anegative regulation of locomotion +
                                is-anegative regulation of long term synaptic depression
                                is-anegative regulation of long-term synaptic potentiation
                                is-anegative regulation of membrane depolarization +
                                is-anegative regulation of membrane hyperpolarization
                                is-anegative regulation of metabolic process +
                                is-anegative regulation of mitotic telomere tethering at nuclear periphery
                                is-anegative regulation of multi-organism process +
                                is-anegative regulation of multicellular organismal process +
                                is-anegative regulation of nitrogen utilization
                                is-anegative regulation of phosphorus utilization
                                is-anegative regulation of proteasome-activating ATPase activity
                                is-anegative regulation of protein localization to cell-cell adherens junction
                                is-anegative regulation of receptor localization to synapse
                                is-anegative regulation of reproductive process +
                                is-anegative regulation of response to stimulus +
                                is-anegative regulation of ribonucleoprotein complex localization +
                                is-anegative regulation of RNA binding transcription factor activity
                                is-anegative regulation of sequence-specific DNA binding transcription factor activity +
                                is-anegative regulation of signaling +
                                is-anegative regulation of sulfur utilization
                                is-anegative regulation of telomerase RNA localization to Cajal body
                                is-anegative regulation of transport +


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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory