Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes USP14
  • Mouse genes Usp14
  • Rat genes Usp14
  • Zfish genes usp14
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Usp14

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP14	IDA		Human	PMID:19106094
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	USP14	IDA		Human	PMID:23958854
Molecular Function	GO:0004866	endopeptidase inhibitor activity	USP14	IMP		Human	PMID:18162577
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	USP14	EXP		Human	PMID:26620909
Molecular Function	GO:0070628	proteasome binding	USP14	IDA		Human	PMID:18162577
Molecular Function	GO:0005515	protein binding	USP14	IPI	UniProtKB:P61073	Human	PMID:19106094
Molecular Function	GO:0005515	protein binding	USP14	IPI	UniProtKB:O75460	Human	PMID:19135427
Molecular Function	GO:0005515	protein binding	USP14	IPI	UniProtKB:Q08209	Human	PMID:19896943
Molecular Function	GO:0005515	protein binding	Usp14	IPI	UniProtKB:Q9EQY0	Mouse	MGI:MGI:3833760|PMID:19135427
Cellular Component	GO:0009986	cell surface	USP14	IDA		Human	PMID:19106094
Cellular Component	GO:0031410	cytoplasmic vesicle	USP14	IDA		Human	PMID:19106094
Cellular Component	GO:0005829	cytosol	USP14	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	USP14	HDA		Human	PMID:23533145
Cellular Component	GO:0005886	plasma membrane	USP14	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045202	synapse	Usp14	IDA		Mouse	PMID:12368914
Biological Process	GO:0007268	chemical synaptic transmission	Usp14	IMP	MGI:MGI:1855959	Mouse	PMID:12368914
Biological Process	GO:1903070	negative regulation of ER-associated ubiquitin-dependent protein catabolic process	USP14	IMP		Human	PMID:19135427
Biological Process	GO:0016579	protein deubiquitination	USP14	IDA		Human	PMID:23958854
Biological Process	GO:0050920	regulation of chemotaxis	USP14	IMP		Human	PMID:19106094
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	USP14	IMP		Human	PMID:18162577

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern