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Gene Ontology Browser
Term Detail
GO term:ubiquitin-specific protease activity
Synonym: deubiquitinase
Synonym: deubiquitinase activity
Synonym: deubiquitinating enzyme
Synonym: deubiquitylase
Synonym: ubiquitin C-terminal hydrolase activity
Synonym: ubiquitin hydrolase activity
Synonym: UBP
Synonym: UCH2
GO id:GO:0004843
Definition:Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin.
CommentsNote that this term is distinguished from 'ubiquitin thiolesterase activity ; GO:0004221' in that it encompasses hydrolysis of a peptide bond formed between ubiquitin and another protein.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-apeptidase activity
                                        is-apeptidase activity, acting on L-amino acid peptides
                                                is-acysteine-type peptidase activity
                                                        is-asmall conjugating protein-specific protease activity
                                                                is-aAtg8-specific protease activity
                                                                is-aISG15-specific protease activity
                                                                is-aNEDD8-specific protease activity
                                                                is-asmall conjugating protein-specific endopeptidase activity +
                                                                is-asmall conjugating protein-specific isopeptidase activity +
                                                                is-aSUMO-specific protease activity +
                                                                is-aubiquitin-specific protease activity [GO:0004843] (79 genes, 120 annotations)
                                                                        is-aLys48-specific deubiquitinase activity
                                                                        is-aLys63-specific deubiquitinase activity
                                                                is-aUFM1 hydrolase activity


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-aubiquitinyl hydrolase activity
                                        is-aubiquitin thiolesterase activity
                                        is-aubiquitin-specific protease activity [GO:0004843] (79 genes, 120 annotations)
                                                is-aLys48-specific deubiquitinase activity
                                                is-aLys63-specific deubiquitinase activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory