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Usp14
Gene Detail
Symbol

Name
ID
Usp14
ubiquitin specific peptidase 14
MGI:1928898
Synonyms
2610005K12Rik, 2610037B11Rik, ataxia, ax, dUB-type TGT, nmf375, NMF375
Feature Type
protein coding gene
Genetic Map
Chromosome 18
4.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr18:9995432-10045119 bp, - strand
From VEGA annotation of GRCm38

  49688 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3780  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ubiquitin carboxyl-terminal hydrolase
Gene Tree: Usp14

Human
homologs
Human Homolog USP14, ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
NCBI Gene ID 9097
neXtProt AC  NX_P54578
Human Synonyms  TGT
Human Chr (Location)  18p11.32; chr18:158483-213739 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Chemically induced (ENU)(1) Gene trapped(25) Spontaneous(1) Targeted(2)
 
Homozygotes for a hypomorphic mutation develop severe tremors by 3 weeks of age, followed by hindlimb paralysis and premature death. An underdeveloped corpus callosum, hippocampus, dentate gyrus and forebrain structures, and notable defects in synaptic transmission in both the CNS and PNS are seen.
 
Interactions
Usp14 interacts with 209 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (4 records)
Data Summary: Results (71)    Tissues (34)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 71
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000020274 (Evidence)
Ensembl Gene ModelENSMUSG00000047879 (Evidence)
Entrez Gene59025 (Evidence)
DFCITC1572431, TC1628414, TC1624245, TC1589972
EC3.4.19.12
PDB1WGG
Consensus CDS ProjectCCDS37734.1, CCDS37735.1
International Mouse Knockout Project StatusUsp14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020274 VEGA Gene Model | MGI Sequence Detail 49688 C57BL/6J ±  kb
transcript OTTMUST00000048112 VEGA | MGI Sequence Detail 2360 Not Applicable 
polypeptide OTTMUSP00000021967 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
InterPro IPR000626 Ubiquitin
InterPro IPR019954 Ubiquitin conserved site
Protein Ontology PR:000017150 ubiquitin carboxyl-terminal hydrolase 14
References
(Earliest) J:24770 Carter TC, New mutants. Mouse News Lett. 1950;2:1
(Latest) J:211136 Marshall AG, et al., Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14). PLoS One. 2013;8(12):e84042
All references(71)
Other
accession IDs
MGD-MRK-1488, MGI:1919366, MGI:1919708, MGI:2147346, MGI:2147405, MGI:3622125, MGI:88124

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory