Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TUSC2
  • Mouse genes Tusc2
  • Rat genes Tusc2
  • Zfish genes tusc2a,tusc2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tusc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TUSC2	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TUSC2	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TUSC2	IPI	UniProtKB:Q93062	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	TUSC2	IPI	UniProtKB:Q99750	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	TUSC2	IPI	UniProtKB:Q5TD97	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TUSC2	IPI	UniProtKB:Q99750	Human	PMID:32296183
Cellular Component	GO:0005739	mitochondrion	Tusc2	IDA		Mouse	PMID:17318811
Biological Process	GO:0048469	cell maturation	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:17318811
Biological Process	GO:0048469	cell maturation	Tusc2	IGI	MGI:MGI:103014	Mouse	PMID:17318811
Biological Process	GO:0071609	chemokine (C-C motif) ligand 5 production	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:22513871
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:24042119
Biological Process	GO:0006954	inflammatory response	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:22513871
Biological Process	GO:0032618	interleukin-15 production	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:17318811
Biological Process	GO:0001779	natural killer cell differentiation	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:17318811
Biological Process	GO:0001779	natural killer cell differentiation	Tusc2	IGI	MGI:MGI:103014	Mouse	PMID:17318811
Biological Process	GO:0032700	negative regulation of interleukin-17 production	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:24042119
Biological Process	GO:0070945	neutrophil-mediated killing of gram-negative bacterium	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:24042119
Biological Process	GO:0006909	phagocytosis	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:24042119
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:24042119
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:24042119
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:22513871
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	Tusc2	IMP	MGI:MGI:3706236	Mouse	PMID:22513871

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern