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Gene Ontology Browser
Term Detail
GO term:natural killer cell differentiation
Synonym: natural killer cell development
Synonym: NK cell differentiation
GO id:GO:0001779
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
CommentsNote that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Number of paths to term: 24

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell activation
                                        is-aleukocyte activation
                                                is-alymphocyte activation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation +
                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                        regulatesregulation of natural killer cell differentiation +
                                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                                regulatesregulation of lymphocyte differentiation +
                                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell activation
                                        is-aleukocyte activation
                                                is-alymphocyte activation
                                                        is-anatural killer cell activation
                                                                part-ofestablishment of natural killer cell polarity
                                                                is-anatural killer cell activation involved in immune response +
                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                        regulatesregulation of natural killer cell differentiation +
                                                                is-anatural killer cell proliferation +
                                                                negatively-regulatesnegative regulation of natural killer cell activation +
                                                                positively-regulatespositive regulation of natural killer cell activation +
                                                                regulatesregulation of natural killer cell activation +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation +
                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                        regulatesregulation of natural killer cell differentiation +
                                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                                regulatesregulation of lymphocyte differentiation +
                                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-aorgan development
                                        is-ahematopoietic or lymphoid organ development
                                                is-ahemopoiesis
                                                        part-ofleukocyte differentiation
                                                                is-alymphocyte differentiation
                                                                        is-aB cell differentiation +
                                                                        is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                                is-anatural killer cell differentiation involved in immune response +
                                                                                negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                                positively-regulatespositive regulation of natural killer cell differentiation +
                                                                                regulatesregulation of natural killer cell differentiation +
                                                                        negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                        positively-regulatespositive regulation of lymphocyte differentiation +
                                                                        regulatesregulation of lymphocyte differentiation +
                                                                        is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        is-aimmune system development
                                                part-ofhematopoietic or lymphoid organ development
                                                        is-ahemopoiesis
                                                                part-ofleukocyte differentiation
                                                                        is-alymphocyte differentiation
                                                                                is-aB cell differentiation +
                                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                                        regulatesregulation of natural killer cell differentiation +
                                                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                                                regulatesregulation of lymphocyte differentiation +
                                                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        part-oforgan development
                                                is-ahematopoietic or lymphoid organ development
                                                        is-ahemopoiesis
                                                                part-ofleukocyte differentiation
                                                                        is-alymphocyte differentiation
                                                                                is-aB cell differentiation +
                                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                                        regulatesregulation of natural killer cell differentiation +
                                                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                                                regulatesregulation of lymphocyte differentiation +
                                                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation +
                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                        regulatesregulation of natural killer cell differentiation +
                                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                                regulatesregulation of lymphocyte differentiation +
                                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-ahematopoietic or lymphoid organ development
                                        is-ahemopoiesis
                                                part-ofleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation +
                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                        regulatesregulation of natural killer cell differentiation +
                                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                                regulatesregulation of lymphocyte differentiation +
                                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation +
                                                                                        is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                                                is-anatural killer cell differentiation involved in immune response +
                                                                                                negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                                                positively-regulatespositive regulation of natural killer cell differentiation +
                                                                                                regulatesregulation of natural killer cell differentiation +
                                                                                        negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                                        positively-regulatespositive regulation of lymphocyte differentiation +
                                                                                        regulatesregulation of lymphocyte differentiation +
                                                                                        is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation +
                                                                                        is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                                                is-anatural killer cell differentiation involved in immune response +
                                                                                                negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                                                positively-regulatespositive regulation of natural killer cell differentiation +
                                                                                                regulatesregulation of natural killer cell differentiation +
                                                                                        negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                                        positively-regulatespositive regulation of lymphocyte differentiation +
                                                                                        regulatesregulation of lymphocyte differentiation +
                                                                                        is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune system development
                                part-ofhematopoietic or lymphoid organ development
                                        is-ahemopoiesis
                                                part-ofleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation +
                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                        regulatesregulation of natural killer cell differentiation +
                                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                                regulatesregulation of lymphocyte differentiation +
                                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aleukocyte activation
                                is-alymphocyte activation
                                        is-alymphocyte differentiation
                                                is-aB cell differentiation +
                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                        is-anatural killer cell differentiation involved in immune response +
                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                        regulatesregulation of natural killer cell differentiation +
                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                regulatesregulation of lymphocyte differentiation +
                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aleukocyte activation
                                is-alymphocyte activation
                                        is-anatural killer cell activation
                                                part-ofestablishment of natural killer cell polarity
                                                is-anatural killer cell activation involved in immune response +
                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                        is-anatural killer cell differentiation involved in immune response +
                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                        regulatesregulation of natural killer cell differentiation +
                                                is-anatural killer cell proliferation +
                                                negatively-regulatesnegative regulation of natural killer cell activation +
                                                positively-regulatespositive regulation of natural killer cell activation +
                                                regulatesregulation of natural killer cell activation +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation +
                                                                                        is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                                                is-anatural killer cell differentiation involved in immune response +
                                                                                                negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                                                positively-regulatespositive regulation of natural killer cell differentiation +
                                                                                                regulatesregulation of natural killer cell differentiation +
                                                                                        negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                                        positively-regulatespositive regulation of lymphocyte differentiation +
                                                                                        regulatesregulation of lymphocyte differentiation +
                                                                                        is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation +
                                                                                        is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                                                is-anatural killer cell differentiation involved in immune response +
                                                                                                negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                                                positively-regulatespositive regulation of natural killer cell differentiation +
                                                                                                regulatesregulation of natural killer cell differentiation +
                                                                                        negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                                        positively-regulatespositive regulation of lymphocyte differentiation +
                                                                                        regulatesregulation of lymphocyte differentiation +
                                                                                        is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation +
                                                                                        is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                                                is-anatural killer cell differentiation involved in immune response +
                                                                                                negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                                                positively-regulatespositive regulation of natural killer cell differentiation +
                                                                                                regulatesregulation of natural killer cell differentiation +
                                                                                        negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                                        positively-regulatespositive regulation of lymphocyte differentiation +
                                                                                        regulatesregulation of lymphocyte differentiation +
                                                                                        is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation +
                                                                                        is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                                                is-anatural killer cell differentiation involved in immune response +
                                                                                                negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                                                positively-regulatespositive regulation of natural killer cell differentiation +
                                                                                                regulatesregulation of natural killer cell differentiation +
                                                                                        negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                                        positively-regulatespositive regulation of lymphocyte differentiation +
                                                                                        regulatesregulation of lymphocyte differentiation +
                                                                                        is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell activation
                                        is-aleukocyte activation
                                                is-alymphocyte activation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation +
                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                        regulatesregulation of natural killer cell differentiation +
                                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                                regulatesregulation of lymphocyte differentiation +
                                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell activation
                                        is-aleukocyte activation
                                                is-alymphocyte activation
                                                        is-anatural killer cell activation
                                                                part-ofestablishment of natural killer cell polarity
                                                                is-anatural killer cell activation involved in immune response +
                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                        regulatesregulation of natural killer cell differentiation +
                                                                is-anatural killer cell proliferation +
                                                                negatively-regulatesnegative regulation of natural killer cell activation +
                                                                positively-regulatespositive regulation of natural killer cell activation +
                                                                regulatesregulation of natural killer cell activation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation +
                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                        regulatesregulation of natural killer cell differentiation +
                                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                                regulatesregulation of lymphocyte differentiation +
                                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation +
                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                        regulatesregulation of natural killer cell differentiation +
                                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                                regulatesregulation of lymphocyte differentiation +
                                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-ahematopoietic or lymphoid organ development
                                        is-ahemopoiesis
                                                part-ofleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation +
                                                                is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                        is-anatural killer cell differentiation involved in immune response +
                                                                        negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                        positively-regulatespositive regulation of natural killer cell differentiation +
                                                                        regulatesregulation of natural killer cell differentiation +
                                                                negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                positively-regulatespositive regulation of lymphocyte differentiation +
                                                                regulatesregulation of lymphocyte differentiation +
                                                                is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation +
                                                                                        is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                                                is-anatural killer cell differentiation involved in immune response +
                                                                                                negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                                                positively-regulatespositive regulation of natural killer cell differentiation +
                                                                                                regulatesregulation of natural killer cell differentiation +
                                                                                        negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                                        positively-regulatespositive regulation of lymphocyte differentiation +
                                                                                        regulatesregulation of lymphocyte differentiation +
                                                                                        is-aT cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation +
                                                                                        is-anatural killer cell differentiation [GO:0001779] (23 genes, 30 annotations)
                                                                                                is-anatural killer cell differentiation involved in immune response +
                                                                                                negatively-regulatesnegative regulation of natural killer cell differentiation +
                                                                                                positively-regulatespositive regulation of natural killer cell differentiation +
                                                                                                regulatesregulation of natural killer cell differentiation +
                                                                                        negatively-regulatesnegative regulation of lymphocyte differentiation +
                                                                                        positively-regulatespositive regulation of lymphocyte differentiation +
                                                                                        regulatesregulation of lymphocyte differentiation +
                                                                                        is-aT cell differentiation +


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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory