Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TTBK2
  • Mouse genes Ttbk2
  • Rat genes Ttbk2
  • Zfish genes ttbk2a,ttbk2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ttbk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019894	kinesin binding	TTBK2	IPI	UniProtKB:Q9WV63	Human	PMID:26323690
Molecular Function	GO:0005515	protein binding	TTBK2	IPI	UniProtKB:Q9UPV0	Human	PMID:22863007
Molecular Function	GO:0005515	protein binding	TTBK2	IPI	UniProtKB:Q53G59	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TTBK2	IPI	UniProtKB:Q9UPY8	Human	PMID:26323690
Molecular Function	GO:0005515	protein binding	TTBK2	IPI	UniProtKB:Q53G59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Ttbk2	IPI	UniProtKB:Q15691	Rat	PMID:26323690|RGD:13461759
Molecular Function	GO:0004672	protein kinase activity	TTBK2	IDA		Human	PMID:26323690
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TTBK2	IDA		Human	PMID:21548880
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Ttbk2	IMP	MGI:MGI:5056320	Mouse	PMID:21548880
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Ttbk2	IMP	MGI:MGI:5496675	Mouse	PMID:23141541
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Ttbk2	IDA		Mouse	PMID:11257498
Cellular Component	GO:0005814	centriole	TTBK2	IDA		Human	PMID:23141541
Cellular Component	GO:0005814	centriole	Ttbk2	IDA		Mouse	PMID:29038301
Cellular Component	GO:0005814	centriole	Ttbk2	IDA		Mouse	PMID:23141541
Cellular Component	GO:0005814	centriole	Ttbk2	IDA		Mouse	PMID:24469809
Cellular Component	GO:0036064	ciliary basal body	Ttbk2	IDA		Mouse	MGI:MGI:5493390|PMID:23141541
Cellular Component	GO:0097546	ciliary base	Ttbk2	IDA		Mouse	PMID:29038301
Cellular Component	GO:0035869	ciliary transition zone	TTBK2	IDA		Human	PMID:23141541
Cellular Component	GO:0035869	ciliary transition zone	Ttbk2	IDA		Mouse	PMID:29038301
Cellular Component	GO:0035869	ciliary transition zone	Ttbk2	IDA		Mouse	PMID:23141541
Cellular Component	GO:0005829	cytosol	TTBK2	IDA		Human	PMID:21548880
Cellular Component	GO:0005615	extracellular space	TTBK2	HDA		Human	PMID:22664934
Cellular Component	GO:0005634	nucleus	TTBK2	IDA		Human	PMID:21548880
Biological Process	GO:0021681	cerebellar granular layer development	Ttbk2	IMP		Mouse	MGI:MGI:5700621|PMID:26323690
Biological Process	GO:0021935	cerebellar granule cell precursor tangential migration	Ttbk2	IMP		Mouse	MGI:MGI:5700621|PMID:26323690
Biological Process	GO:0021549	cerebellum development	Ttbk2	IMP		Mouse	MGI:MGI:5700621|PMID:26323690
Biological Process	GO:0060271	cilium assembly	TTBK2	IMP		Human	PMID:23141541
Biological Process	GO:0060271	cilium assembly	Ttbk2	IMP		Mouse	MGI:MGI:5493390|PMID:23141541
Biological Process	GO:1990403	embryonic brain development	Ttbk2	IMP	MGI:MGI:5056320	Mouse	PMID:21548880
Biological Process	GO:0042733	embryonic digit morphogenesis	Ttbk2	IMP	MGI:MGI:5496675	Mouse	PMID:23141541
Biological Process	GO:0030900	forebrain development	Ttbk2	IMP	MGI:MGI:5496675	Mouse	PMID:23141541
Biological Process	GO:0000226	microtubule cytoskeleton organization	TTBK2	IGI	UniProtKB:O00139	Human	PMID:26323690
Biological Process	GO:1904527	negative regulation of microtubule binding	TTBK2	IDA		Human	PMID:26323690
Biological Process	GO:0007026	negative regulation of microtubule depolymerization	TTBK2	IDA		Human	PMID:26323690
Biological Process	GO:1903828	negative regulation of protein localization	Ttbk2	IMP	MGI:MGI:5496675	Mouse	PMID:23141541
Biological Process	GO:1902817	negative regulation of protein localization to microtubule	TTBK2	IMP		Human	PMID:26323690
Biological Process	GO:0021915	neural tube development	Ttbk2	IMP	MGI:MGI:5496675	Mouse	PMID:23141541
Biological Process	GO:0018105	peptidyl-serine phosphorylation	TTBK2	IDA		Human	PMID:21548880
Biological Process	GO:0018105	peptidyl-serine phosphorylation	TTBK2	IDA		Human	PMID:26323690
Biological Process	GO:0018105	peptidyl-serine phosphorylation	TTBK2	IDA		Human	PMID:30375385
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Ttbk2	IDA		Mouse	PMID:11257498
Biological Process	GO:1902857	positive regulation of non-motile cilium assembly	Ttbk2	IMP	MGI:MGI:5496675	Mouse	PMID:23141541
Biological Process	GO:0008104	protein localization	Ttbk2	IMP	MGI:MGI:5496675	Mouse	PMID:23141541
Biological Process	GO:0033365	protein localization to organelle	Ttbk2	IMP		Mouse	PMID:29038301
Biological Process	GO:0030334	regulation of cell migration	TTBK2	IGI	UniProtKB:O00139	Human	PMID:26323690
Biological Process	GO:0008589	regulation of smoothened signaling pathway	Ttbk2	IMP	MGI:MGI:5496675	Mouse	PMID:23141541
Biological Process	GO:0007224	smoothened signaling pathway	Ttbk2	IMP		Mouse	MGI:MGI:5493390|PMID:23141541

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern