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Ttbk2 Gene Detail
Summary
  • Symbol
    Ttbk2
  • Name
    tau tubulin kinase 2
  • Synonyms
    2610507N02Rik, B930008N24Rik, TTK
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155779
    NCBI Gene: 140810
  • Gene Overview
    MyGene.info: TTBK2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:120732816-120850584 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 60.37 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    576 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155779
protein coding gene Chr2:120732816-120850604 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026374
protein coding gene Chr2:123607955-123717260 (-)
A/J MGP_AJ_G0026335
protein coding gene Chr2:118551210-118655861 (-)
AKR/J MGP_AKRJ_G0026314
protein coding gene Chr2:121861021-121979109 (-)
BALB/cJ MGP_BALBcJ_G0026348
protein coding gene Chr2:118790371-118893956 (-)
C3H/HeJ MGP_C3HHeJ_G0026094
protein coding gene Chr2:122360630-122468821 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026795
protein coding gene Chr2:127647440-127771113 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024175
protein coding gene Chr2:113564877-113689317 (-)
CAST/EiJ MGP_CASTEiJ_G0025556
protein coding gene Chr2:122663101-122770136 (-)
CBA/J MGP_CBAJ_G0026070
protein coding gene Chr2:132111683-132223857 (-)
DBA/2J MGP_DBA2J_G0026209
protein coding gene Chr2:117943228-118044755 (-)
FVB/NJ MGP_FVBNJ_G0026171
protein coding gene Chr2:116774962-116879284 (-)
LP/J MGP_LPJ_G0026310
protein coding gene Chr2:123871740-123978909 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026190
protein coding gene Chr2:136410921-136523821 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026850
protein coding gene Chr2:121991042-122103284 (-)
PWK/PhJ MGP_PWKPhJ_G0025292
protein coding gene Chr2:117545090-117658529 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025091
protein coding gene Chr2:121194394-121319096 (-)
WSB/EiJ MGP_WSBEiJ_G0025625
protein coding gene Chr2:122823058-122933234 (-)



Homology
more
  • Human Ortholog
    TTBK2, tau tubulin kinase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TTBK2, tau tubulin kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SCA11, TTBK
  • Links
    NCBI Gene ID: 146057
    neXtProt AC: NX_Q6IQ55
    UniProt: Q6IQ55

  • Chr Location
    15q15.2; chr15:42738974-42920995 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TTBK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit complete preweaning lethality, decreased embryo size, growth retardation, and incomplete turning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 140810 NCBI Gene Model | MGI Sequence Detail 117769 C57BL/6J ±  kb
    transcript NM_001024856 RefSeq | MGI Sequence Detail 11152 C57BL/6  
    polypeptide Q3UVR3 UniProt | EBI | MGI Sequence Detail 1243 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 58

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1921460, MGI:2138912, MGI:2443971
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:227522 Watanabe T, et al., TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. J Cell Biol. 2015 Aug 31;210(5):737-51

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory