Ttbk2
Gene Detail

Symbol Name ID

Ttbk2 tau tubulin kinase 2 MGI:2155779

Synonyms

2610507N02Rik, B930008N24Rik, TTK

Feature Type

protein coding gene

Genetic Map

Chromosome 2

60.37 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:120732816-120850604 bp, - strand From VEGA annotation of GRCm38   117789 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:62795  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ttbk2

Human homologs

Human Homolog		TTBK2, tau tubulin kinase 2
NCBI Gene ID		146057
neXtProt AC		NX_Q6IQ55
Human Synonyms		SCA11, TTBK
Human Chr (Location)		15q15.2; chr15:43036536-43213007 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TTBK2

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for a knock-in allele exhibit complete preweaning lethality, decreased embryo size, growth retardation, and incomplete turning.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	peptidyl-serine phosphorylation
Component	cytosol, nucleus
Function	protein serine/threonine kinase activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (39)    Tissues (8)    Images (19)
Theiler Stages: 23

Assay Type	Results
RNA in situ	39

cDNA source data(56)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(57) cDNA(56) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000015707 (Evidence)
Ensembl Gene Model	ENSMUSG00000090100 (Evidence)
Entrez Gene	140810 (Evidence)
UniGene	275698
DoTS	DT.110724871, DT.50316453, DT.60103514, DT.91321562, DT.91330572, DT.94239675
Consensus CDS Project	CCDS16626.1, CCDS16627.1
International Mouse Knockout Project Status	Ttbk2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015707	VEGA Gene Model | MGI Sequence Detail	117789	C57BL/6J
transcript	OTTMUST00000037322	VEGA | MGI Sequence Detail	10926	Not Applicable
polypeptide	OTTMUSP00000016716	VEGA | MGI Sequence Detail	1312	Not Applicable

All sequences(52) RefSeq(6)

Polymorphisms

SNPs(388 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000016778	tau-tubulin kinase 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173629 Bouskila M, et al., TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Biochem J. 2011 Jul 1;437(1):157-67
All references(29)

Other accession IDs

MGI:1921460, MGI:2138912, MGI:2443971