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Ttbk2
Gene Detail
Symbol

Name
ID
Ttbk2
tau tubulin kinase 2
MGI:2155779
Synonyms
2610507N02Rik, B930008N24Rik, TTK
Feature Type
protein coding gene
Genetic Map
Chromosome 2
60.37 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:120732816-120850604 bp, - strand
From VEGA annotation of GRCm38

  117789 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62795  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Ttbk2

Human
homologs
Human Homolog TTBK2, tau tubulin kinase 2
NCBI Gene ID 146057
neXtProt AC  NX_Q6IQ55
Human Synonyms  SCA11, TTBK
Human Chr (Location)  15q15.2; chr15:42743953-42920995 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TTBK2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit complete preweaning lethality, decreased embryo size, growth retardation, and incomplete turning.
 
Interactions
Ttbk2 interacts with 513 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process peptidyl-serine phosphorylation, regulation of cell shape
Component centriole, cytosol, ...
Function protein serine/threonine kinase activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (39)    Tissues (8)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
cDNA source data(56)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) cDNA(56) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015707 (Evidence)
Ensembl Gene ModelENSMUSG00000090100 (Evidence)
Entrez Gene140810 (Evidence)
UniGene275698
DoTSDT.60103514, DT.110724871, DT.50316453, DT.91321562, DT.94239675, DT.91330572
Consensus CDS ProjectCCDS16626.1, CCDS16627.1
International Mouse Knockout Project StatusTtbk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015707 VEGA Gene Model | MGI Sequence Detail 117789 C57BL/6J ±  kb
transcript OTTMUST00000037322 VEGA | MGI Sequence Detail 10926 Not Applicable 
polypeptide OTTMUSP00000016716 VEGA | MGI Sequence Detail 1312 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6)
Polymorphisms
SNPs within 2kb(623 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000016778 tau-tubulin kinase 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206657 Ye X, et al., C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2164-9
All references(33)
Other
accession IDs
MGI:1921460, MGI:2138912, MGI:2443971

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory