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Ttbk2
Gene Detail
Symbol

Name
ID
Ttbk2
tau tubulin kinase 2
MGI:2155779
Synonyms
2610507N02Rik, B930008N24Rik, TTK
Feature Type
protein coding gene
Genetic Map
Chromosome 2
60.37 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:120732816-120850604 bp, - strand
From VEGA annotation of GRCm38

  117789 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62795  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TTBK2
Gene Tree: Ttbk2

Human
homologs
TTBK2, tau tubulin kinase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 146057
neXtProt AC: NX_Q6IQ55

Human Synonyms: SCA11, TTBK

Human Chr (Location): 15q15.2; chr15:42738734-42921007 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TTBK2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit complete preweaning lethality, decreased embryo size, growth retardation, and incomplete turning.
 
Interactions
Ttbk2 interacts with 512 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process peptidyl-serine phosphorylation, regulation of cell shape
Component centriole, cytoplasm, ...
Function protein serine/threonine kinase activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (39)    Tissues (8)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
cDNA source data(56)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ttbk2    NEW 
Molecular
reagents
All nucleic(57) cDNA(56) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000015707 (Evidence)
Ensembl Gene Model ENSMUSG00000090100 (Evidence)
Entrez Gene 140810 (Evidence)
UniGene 275698
DoTS DT.110724871, DT.60103514, DT.50316453, DT.91321562, DT.91330572, DT.94239675
Consensus CDS Project CCDS16626.1, CCDS16627.1
International Mouse Phenotyping Consortium Status Ttbk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015707 VEGA Gene Model | MGI Sequence Detail 117789 C57BL/6J ±  kb
transcript OTTMUST00000037322 VEGA | MGI Sequence Detail 10926 Not Applicable 
polypeptide OTTMUSP00000016716 VEGA | MGI Sequence Detail 1312 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6)
Polymorphisms
SNPs within 2kb(623 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000016778 tau-tubulin kinase 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206657 Ye X, et al., C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2164-9
All references(32)
Other
accession IDs
MGI:1921460, MGI:2138912, MGI:2443971

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory