Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRPV4
  • Mouse genes Trpv4
  • Rat genes Trpv4
  • Zfish genes trpv4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpv4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Molecular Function	GO:0051015	actin filament binding	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Molecular Function	GO:0043014	alpha-tubulin binding	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Molecular Function	GO:0048487	beta-tubulin binding	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Molecular Function	GO:0005262	calcium channel activity	TRPV4	IDA		Human	PMID:18458941
Molecular Function	GO:0005262	calcium channel activity	TRPV4	IDA		Human	PMID:29899501
Molecular Function	GO:0005262	calcium channel activity	Trpv4	IMP		Mouse	MGI:MGI:5486547|PMID:18174177
Molecular Function	GO:0005262	calcium channel activity	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Molecular Function	GO:0005262	calcium channel activity	Trpv4	IDA		Mouse	MGI:MGI:2653708|PMID:12538589
Molecular Function	GO:0005262	calcium channel activity	Trpv4	IDA		Mouse	PMID:14517216
Molecular Function	GO:0005262	calcium channel activity	Trpv4	IDA		Mouse	PMID:11025659
Molecular Function	GO:0005262	calcium channel activity	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Molecular Function	GO:0005262	calcium channel activity	Trpv4	IMP		Rat	PMID:23136043|RGD:10400856
Molecular Function	GO:0005516	calmodulin binding	TRPV4	IMP		Human	PMID:12724311
Molecular Function	GO:0042802	identical protein binding	TRPV4	IPI	UniProtKB:Q9HBA0	Human	PMID:26146187
Molecular Function	GO:0008017	microtubule binding	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Molecular Function	GO:0005261	monoatomic cation channel activity	TRPV4	IDA		Human	PMID:12724311
Molecular Function	GO:0005261	monoatomic cation channel activity	Trpv4	IDA		Rat	PMID:11081638|RGD:68824
Molecular Function	GO:0005034	osmosensor activity	Trpv4	IDA		Mouse	PMID:11025659
Molecular Function	GO:0005034	osmosensor activity	Trpv4	IMP	MGI:MGI:2667379	Mouse	PMID:12777254
Molecular Function	GO:0005515	protein binding	TRPV4	IPI	UniProtKB:P47863	Human	PMID:21262839
Molecular Function	GO:0005515	protein binding	TRPV4	IPI	UniProtKB:P47863-1	Human	PMID:21262839
Molecular Function	GO:0005515	protein binding	TRPV4	IPI	UniProtKB:O00571	Human	PMID:29899501
Molecular Function	GO:0005515	protein binding	Trpv4	IPI	UniProtKB:P55088	Mouse	MGI:MGI:4939848|PMID:21262839
Molecular Function	GO:0005515	protein binding	Trpv4	IPI	UniProtKB:Q13563	Mouse	MGI:MGI:6356106|PMID:25114176
Molecular Function	GO:0005515	protein binding	Trpv4	IPI	UniProtKB:Q99JB8	Mouse	MGI:MGI:5486547|PMID:18174177
Molecular Function	GO:0005515	protein binding	Trpv4	IPI	UniProtKB:P0CG48	Mouse	MGI:MGI:5508618|PMID:17110928
Molecular Function	GO:0005515	protein binding	Trpv4	IPI	UniProtKB:P48995	Mouse	MGI:MGI:6356106|PMID:25114176
Molecular Function	GO:0005515	protein binding	Trpv4	IPI	UniProtKB:Q02248	Mouse	MGI:MGI:4820667|PMID:20413591
Molecular Function	GO:0005515	protein binding	Trpv4	IPI	PR:O88735	Mouse	PMID:14517216
Molecular Function	GO:0005515	protein binding	Trpv4	IPI	RGD:2156	Rat	PMID:20650893|RGD:5509917
Molecular Function	GO:0005515	protein binding	Trpv4	IPI	RGD:68977	Rat	PMID:20650893|RGD:5509917
Molecular Function	GO:0005515	protein binding	Trpv4	IPI	UniProtKB:P47863	Rat	PMID:21262839|RGD:13432264
Molecular Function	GO:0005515	protein binding	Trpv4	IPI	UniProtKB:P47863-1	Rat	PMID:21262839|RGD:13432264
Molecular Function	GO:0019901	protein kinase binding	TRPV4	IPI	UniProtKB:P07947	Human	PMID:12538589
Molecular Function	GO:0019901	protein kinase binding	TRPV4	IPI	UniProtKB:P07948	Human	PMID:12538589
Molecular Function	GO:0019901	protein kinase binding	TRPV4	IPI	UniProtKB:P12931	Human	PMID:12538589
Molecular Function	GO:0019901	protein kinase binding	Trpv4	IPI	UniProtKB:P07948	Mouse	MGI:MGI:2653708|PMID:12538589
Molecular Function	GO:0005080	protein kinase C binding	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Molecular Function	GO:0042169	SH2 domain binding	Trpv4	IPI	UniProtKB:P39688	Mouse	MGI:MGI:2653708|PMID:12538589
Molecular Function	GO:0015275	stretch-activated, monoatomic cation-selective, calcium channel activity	TRPV4	IMP		Human	PMID:23136043
Cellular Component	GO:0005912	adherens junction	Trpv4	IDA		Mouse	MGI:MGI:4820667|PMID:20413591
Cellular Component	GO:0009986	cell surface	Trpv4	IDA		Rat	PMID:20650893|RGD:5509917
Cellular Component	GO:0005929	cilium	Trpv4	IDA		Mouse	PMID:15858826
Cellular Component	GO:0030864	cortical actin cytoskeleton	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Cellular Component	GO:0005881	cytoplasmic microtubule	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Cellular Component	GO:0031410	cytoplasmic vesicle	Trpv4	IDA		Rat	PMID:20650893|RGD:5509917
Cellular Component	GO:0030175	filopodium	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Cellular Component	GO:0005925	focal adhesion	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Cellular Component	GO:0030426	growth cone	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Cellular Component	GO:0030027	lamellipodium	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Cellular Component	GO:0005886	plasma membrane	TRPV4	IDA		Human	PMID:15753126
Cellular Component	GO:0005886	plasma membrane	TRPV4	IDA		Human	PMID:23136043
Cellular Component	GO:0005886	plasma membrane	TRPV4	IDA		Human	PMID:29899501
Cellular Component	GO:0005886	plasma membrane	Trpv4	IDA		Mouse	MGI:MGI:4820667|PMID:20413591
Cellular Component	GO:0005886	plasma membrane	Trpv4	IDA		Mouse	MGI:MGI:2653708|PMID:12538589
Cellular Component	GO:0005886	plasma membrane	Trpv4	IDA		Mouse	PMID:14517216
Cellular Component	GO:0032587	ruffle membrane	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Biological Process	GO:0031532	actin cytoskeleton reorganization	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Biological Process	GO:0007015	actin filament organization	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Biological Process	GO:0003171	atrioventricular valve development	trpv4	IMP	ZFIN:ZDB-GENO-171213-3	Zfish	PMID:25959969
Biological Process	GO:0097497	blood vessel endothelial cell delamination	TRPV4	IMP		Human	PMID:23136043
Biological Process	GO:0070509	calcium ion import	Trpv4	IDA		Mouse	MGI:MGI:2653708|PMID:12538589
Biological Process	GO:0070509	calcium ion import	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Biological Process	GO:1902656	calcium ion import into cytosol	TRPV4	IDA		Human	PMID:29899501
Biological Process	GO:0070588	calcium ion transmembrane transport	TRPV4	IMP		Human	PMID:23136043
Biological Process	GO:0070588	calcium ion transmembrane transport	Trpv4	IMP		Rat	PMID:23136043|RGD:10400856
Biological Process	GO:0006816	calcium ion transport	TRPV4	IDA		Human	PMID:18458941
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	TRPV4	IMP		Human	PMID:26249260
Biological Process	GO:0007043	cell-cell junction assembly	Trpv4	IMP		Mouse	MGI:MGI:4820667|PMID:20413591
Biological Process	GO:0071476	cellular hypotonic response	TRPV4	IMP		Human	PMID:23136043
Biological Process	GO:0071476	cellular hypotonic response	Trpv4	IDA		Mouse	MGI:MGI:2653708|PMID:12538589
Biological Process	GO:0071477	cellular hypotonic salinity response	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0034605	cellular response to heat	Trpv4	IMP		Mouse	MGI:MGI:5486547|PMID:18174177
Biological Process	GO:0097704	cellular response to oscillatory fluid shear stress	trpv4	IMP	ZFIN:ZDB-GENO-171213-3	Zfish	PMID:25959969
Biological Process	GO:0071470	cellular response to osmotic stress	Trpv4	IMP		Mouse	MGI:MGI:5486547|PMID:18174177
Biological Process	GO:0043622	cortical microtubule organization	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Biological Process	GO:0002024	diet induced thermogenesis	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0097009	energy homeostasis	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0042593	glucose homeostasis	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0042538	hyperosmotic salinity response	Trpv4	IMP	MGI:MGI:2667379	Mouse	PMID:12777254
Biological Process	GO:0006971	hypotonic response	Trpv4	IDA		Rat	PMID:11081638|RGD:68824
Biological Process	GO:0006874	intracellular calcium ion homeostasis	TRPV4	IDA		Human	PMID:12724311
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Trpv4	IMP		Mouse	MGI:MGI:5486547|PMID:18174177
Biological Process	GO:0046785	microtubule polymerization	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	TRPV4	IMP		Human	PMID:23136043
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	Trpv4	IMP		Rat	PMID:23136043|RGD:10400856
Biological Process	GO:1903444	negative regulation of brown fat cell differentiation	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0010977	negative regulation of neuron projection development	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0007231	osmosensory signaling pathway	Trpv4	IDA		Mouse	MGI:MGI:2653708|PMID:12538589
Biological Process	GO:0007231	osmosensory signaling pathway	Trpv4	IDA		Mouse	PMID:11025659
Biological Process	GO:0007231	osmosensory signaling pathway	Trpv4	IMP	MGI:MGI:2667379	Mouse	PMID:12777254
Biological Process	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	TRPV4	IDA		Human	PMID:18458941
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Trpv4	IDA		Rat	PMID:20650893|RGD:5509917
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0010628	positive regulation of gene expression	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0050729	positive regulation of inflammatory response	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0046330	positive regulation of JNK cascade	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0071642	positive regulation of macrophage inflammatory protein 1 alpha production	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0031117	positive regulation of microtubule depolymerization	Trpv4	IDA		Rat	PMID:20657843|RGD:8553293
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0045989	positive regulation of striated muscle contraction	Trpv4	IMP		Rat	PMID:32706268|RGD:38549369
Biological Process	GO:0043117	positive regulation of vascular permeability	TRPV4	IMP		Human	PMID:23136043
Biological Process	GO:0043117	positive regulation of vascular permeability	Trpv4	IMP		Mouse	MGI:MGI:5688830|PMID:23136043
Biological Process	GO:0043117	positive regulation of vascular permeability	Trpv4	IMP		Rat	PMID:23136043|RGD:10400856
Biological Process	GO:1903715	regulation of aerobic respiration	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0047484	regulation of response to osmotic stress	Trpv4	IMP	MGI:MGI:2667379	Mouse	PMID:12777254
Biological Process	GO:0032868	response to insulin	Trpv4	IMP		Mouse	MGI:MGI:5440106|PMID:23021218
Biological Process	GO:0006970	response to osmotic stress	Trpv4	IDA		Mouse	PMID:11025659
Biological Process	GO:0006970	response to osmotic stress	Trpv4	IPI	UniProtKB:Q7TQL9	Mouse	PMID:14517216
Biological Process	GO:0006970	response to osmotic stress	trpv4	IMP	ZFIN:ZDB-MRPHLNO-081020-1	Zfish	PMID:26673139
Biological Process	GO:0030103	vasopressin secretion	Trpv4	IMP	MGI:MGI:2667379	Mouse	PMID:12777254

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern