Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRIB1
  • Mouse genes Trib1
  • Rat genes Trib1
  • Zfish genes trib1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trib1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	TRIB1	IDA		Human	PMID:15299019
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	TRIB1	IDA		Human	PMID:17452330
Molecular Function	GO:0005515	protein binding	TRIB1	IPI	UniProtKB:Q8N2I9	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	TRIB1	IPI	UniProtKB:Q8N2I9	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TRIB1	IPI	UniProtKB:Q8N2I9	Human	PMID:32707033
Molecular Function	GO:0004860	protein kinase inhibitor activity	TRIB1	IMP		Human	PMID:15299019
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	TRIB1	IPI	UniProtKB:P17676	Human	PMID:17724128
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Trib1	IPI	UniProtKB:P28033	Mouse	MGI:MGI:3760491|PMID:17724128
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Trib1	IDA		Mouse	MGI:MGI:4457446|PMID:20410507
Molecular Function	GO:0055106	ubiquitin-protein transferase regulator activity	Trib1	IDA		Mouse	MGI:MGI:4457446|PMID:20410507
Cellular Component	GO:0005737	cytoplasm	TRIB1	IDA		Human	PMID:17452330
Cellular Component	GO:0005634	nucleus	TRIB1	IDA		Human	PMID:17452330
Biological Process	GO:0007254	JNK cascade	TRIB1	IMP		Human	PMID:17452330
Biological Process	GO:0001889	liver development	trib1	IMP	ZFIN:ZDB-MRPHLNO-131120-3	Zfish	PMID:23813869
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	TRIB1	IMP		Human	PMID:15299019
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Trib1	IDA		Mouse	MGI:MGI:3760491|PMID:17724128
Biological Process	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	TRIB1	IMP		Human	PMID:17452330
Biological Process	GO:0045659	negative regulation of neutrophil differentiation	Trib1	IMP		Mouse	MGI:MGI:5488531|PMID:23515163
Biological Process	GO:0006469	negative regulation of protein kinase activity	TRIB1	IMP		Human	PMID:15299019
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	TRIB1	IMP		Human	PMID:17452330
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	TRIB1	IMP		Human	PMID:17452330
Biological Process	GO:0045645	positive regulation of eosinophil differentiation	Trib1	IMP		Mouse	MGI:MGI:5488531|PMID:23515163
Biological Process	GO:0045651	positive regulation of macrophage differentiation	Trib1	IMP		Mouse	MGI:MGI:5488531|PMID:23515163
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Trib1	IDA		Mouse	MGI:MGI:4457446|PMID:20410507
Biological Process	GO:0043405	regulation of MAP kinase activity	TRIB1	IDA		Human	PMID:15299019
Biological Process	GO:0032496	response to lipopolysaccharide	TRIB1	IMP		Human	PMID:17452330
Biological Process	GO:0032496	response to lipopolysaccharide	Trib1	IMP		Mouse	MGI:MGI:3760491|PMID:17724128

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern