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Trib1 Gene Detail
Summary
  • Symbol
    Trib1
  • Name
    tribbles pseudokinase 1
  • Synonyms
    A530090O15Rik, Trb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443397
    NCBI Gene: 211770
  • Gene Overview
    MyGene.info: TRIB1
Location & Maps
more
  • Sequence Map
    Chr15:59648350-59656550 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8201 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 25.41 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TRIB1, tribbles pseudokinase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRIB1, tribbles pseudokinase 1
    Orthology source: HomoloGene
  • Synonyms
    C8FW, GIG2, GIG-2, SKIP1, TRB1, TRB-1
  • Links
    NCBI Gene ID: 10221
    neXtProt AC: NX_Q96RU8

  • Chr Location
    8q24.13; chr8:125430321-125438405 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    3
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    5 involving Trib1
  • Incidental Mutations
    APF
Macrophages from mice homozygous for a knock-out allele exhibit impaired IL12 response to LPS, MALP-1, or CpG DNA.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028043 VEGA Gene Model | MGI Sequence Detail 8201 C57BL/6J ±  kb
transcript OTTMUST00000069447 VEGA | MGI Sequence Detail 3781 Not Applicable  
polypeptide OTTMUSP00000035268 VEGA | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    17 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016638 tribbles homolog 1
  • InterPro Domains
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR024104 Pseudokinase tribbles family/serine-threonine-protein kinase 40
    IPR024105 Tribbles homologue 1
Molecular
Reagents
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  • All nucleic 14
    cDNA 12
    Primer pair 1
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 29
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 5
    Phenotypes 27
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:215219 Ord T, et al., Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet. PLoS One. 2014;9(4):e94691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory