Trib1 MGI Mouse Gene Detail - MGI:2443397

Symbol

Trib1
Name

tribbles pseudokinase 1
Synonyms

A530090O15Rik, Trb1

Feature Type

protein coding gene
IDs

MGI:2443397
NCBI Gene: 211770
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr15:59520503-59528948 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 25.41 cM
Mapping Data

1 experiment

SNPs within 2kb

17 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443397	protein coding gene	Chr15:59520199-59528948 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021885	protein coding gene	Chr15:58897984-58907463 (+)
A/J	MGP_AJ_G0021845	protein coding gene	Chr15:56597004-56605245 (+)
AKR/J	MGP_AKRJ_G0021826	protein coding gene	Chr15:58151633-58159844 (+)
BALB/cJ	MGP_BALBcJ_G0021852	protein coding gene	Chr15:56808795-56817007 (+)
C3H/HeJ	MGP_C3HHeJ_G0021626	protein coding gene	Chr15:58282588-58291699 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022291	protein coding gene	Chr15:61139318-61147414 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019828	protein coding gene	Chr15:53662613-53670898 (+)
CAST/EiJ	MGP_CASTEiJ_G0021143	protein coding gene	Chr15:58977005-58985221 (+)
CBA/J	MGP_CBAJ_G0021595	protein coding gene	Chr15:63295120-63305169 (+)
DBA/2J	MGP_DBA2J_G0021719	protein coding gene	Chr15:56502461-56510699 (+)
FVB/NJ	MGP_FVBNJ_G0021697	protein coding gene	Chr15:55558153-55566542 (+)
LP/J	MGP_LPJ_G0021789	protein coding gene	Chr15:58757463-58765662 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021721	protein coding gene	Chr15:68319363-68327606 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022314	protein coding gene	Chr15:58558795-58566997 (+)
PWK/PhJ	MGP_PWKPhJ_G0020888	protein coding gene	Chr15:56527064-56535297 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020725	protein coding gene	Chr15:58341701-58349901 (+)
WSB/EiJ	MGP_WSBEiJ_G0021198	protein coding gene	Chr15:58569447-58577638 (+)

Human Ortholog

TRIB1, tribbles pseudokinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIB1, tribbles pseudokinase 1
Synonyms

C8FW, GIG2, GIG-2, SKIP1, TRB1, TRB-1
Links

HGNC:16891

NCBI Gene ID: 10221

neXtProt AC: NX_Q96RU8

UniProt: Q96RU8
Chr Location

8q24.13; chr8:125430358-125438403 (+) GRCh38

MGI Vertebrate Homology

Trib1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRIB1
Gene Tree

Trib1

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References

1 with disease annotations

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Phenotype Summary

21 phenotypes from 2 alleles in 2 genetic backgrounds
43 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

3
Endonuclease-mediated

2
Radiation induced

2
Targeted

8
Genomic Mutations

5 involving Trib1
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Macrophages from mice homozygous for a knock-out allele exhibit impaired IL12 response to LPS, MALP-1, or CpG DNA.

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All GO Annotations

37
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

68
cDNA Data

13
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trib1

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All Sequences

42
RefSeq

2
UniProt

1
CCDS

CCDS27499.1

Ensembl

ENSMUSG00000032501 (Evidence)
NCBI Gene

211770

			Length	Strain/Species	Flank
genomic	211770	NCBI Gene Model \| MGI Sequence Detail	8446	C57BL/6J	± kb
transcript	NM_144549	RefSeq \| MGI Sequence Detail	4026	C57BL/6
polypeptide	Q8K4K4	UniProt \| EBI \| MGI Sequence Detail	372	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016638 tribbles homolog 1

(term hierarchy)
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR024104 Pseudokinase tribbles family/serine-threonine-protein kinase 40

IPR024105 Tribbles homologue 1, pseudokinase domain

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All nucleic 16

cDNA 13

Primer pair 2

Other 1

Microarray probesets 5

Summaries

All 75

Developmental Gene Expression 5

Diseases 1

Gene Ontology 7

Phenotypes 43
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:319702 Yoshino S, et al., Trib1 promotes the development of acute myeloid leukemia in a Ts1Cje mouse model of Down syndrome. Leukemia. 2022 Feb;36(2):558-561

TSS for Trib1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131384	Chr15:59520146-59520156 (+)	-352 bp
Tssr131385	Chr15:59520205-59520218 (+)	-291 bp
Tssr131386	Chr15:59520271-59520280 (+)	-227 bp
Tssr131387	Chr15:59520352-59520386 (+)	-134 bp
Tssr131388	Chr15:59520399-59520410 (+)	-98 bp
Tssr131389	Chr15:59520427-59520438 (+)	-70 bp
Tssr131390	Chr15:59520493-59520536 (+)	12 bp
Tssr131391	Chr15:59520543-59520554 (+)	46 bp
Tssr131392	Chr15:59522573-59522606 (+)	2,087 bp
Tssr131393	Chr15:59524934-59524982 (+)	4,455 bp
Tssr131394	Chr15:59525260-59525272 (+)	4,763 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23