Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase regulator activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of myeloid leukocyte differentiation; and response to lipopolysaccharide. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and submandibular gland primordium. Orthologous to human TRIB1 (tribbles pseudokinase 1).