Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes THBS4
  • Mouse genes Thbs4
  • Rat genes Thbs4
  • Zfish genes thbs4a,thbs4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Thbs4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	THBS4	IDA		Human	PMID:16246837
Molecular Function	GO:0005509	calcium ion binding	THBS4	IDA		Human	PMID:7852353
Molecular Function	GO:0005518	collagen binding	Thbs4	IDA		Rat	PMID:10956668|RGD:1580072
Molecular Function	GO:0001968	fibronectin binding	Thbs4	IDA		Rat	PMID:10956668|RGD:1580072
Molecular Function	GO:0008201	heparin binding	THBS4	IDA		Human	PMID:7852353
Molecular Function	GO:0042802	identical protein binding	Thbs4	IPI	RGD:62046	Rat	PMID:10956668|RGD:1580072
Molecular Function	GO:0005178	integrin binding	THBS4	IDA		Human	PMID:16099885
Molecular Function	GO:0043237	laminin-1 binding	Thbs4	IDA		Rat	PMID:10956668|RGD:1580072
Molecular Function	GO:0005515	protein binding	THBS4	IPI	UniProtKB:P18850	Human	PMID:22682248
Molecular Function	GO:0005515	protein binding	Thbs4	IPI	UniProtKB:F6VAN0	Mouse	MGI:MGI:5431143|PMID:22682248
Cellular Component	GO:0005604	basement membrane	THBS4	IDA		Human	PMID:17927980
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Thbs4	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Thbs4	IDA		Mouse	MGI:MGI:5436396|PMID:22362893
Cellular Component	GO:0005783	endoplasmic reticulum	Thbs4	IDA		Mouse	MGI:MGI:5431143|PMID:22682248
Cellular Component	GO:0070062	extracellular exosome	THBS4	HDA		Human	PMID:23533145
Cellular Component	GO:0031012	extracellular matrix	Thbs4	IDA		Rat	PMID:7490284|RGD:61768
Cellular Component	GO:0005615	extracellular space	THBS4	IDA		Human	PMID:12952849
Cellular Component	GO:0005615	extracellular space	THBS4	IDA		Human	PMID:18802666
Cellular Component	GO:0005615	extracellular space	Thbs4	IDA		Mouse	MGI:MGI:5431143|PMID:22682248
Cellular Component	GO:0031594	neuromuscular junction	Thbs4	IDA		Rat	PMID:7490284|RGD:61768
Cellular Component	GO:0016529	sarcoplasmic reticulum	Thbs4	IDA		Mouse	MGI:MGI:5431143|PMID:22682248
Biological Process	GO:0048266	behavioral response to pain	Thbs4	IMP		Mouse	MGI:MGI:5516179|PMID:22745497
Biological Process	GO:0048266	behavioral response to pain	Thbs4	IMP		Rat	PMID:22745497|RGD:8553360
Biological Process	GO:0071603	endothelial cell-cell adhesion	THBS4	IDA		Human	PMID:12952849
Biological Process	GO:0051451	myoblast migration	THBS4	IDA		Human	PMID:7519904
Biological Process	GO:0016525	negative regulation of angiogenesis	THBS4	IEP		Human	PMID:18802666
Biological Process	GO:0007399	nervous system development	Thbs4	IDA		Rat	PMID:7490284|RGD:61768
Biological Process	GO:0048812	neuron projection morphogenesis	Thbs4	IDA		Rat	PMID:7490284|RGD:61768
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	THBS4	IDA		Human	PMID:12952849
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	THBS4	IDA		Human	PMID:16099885
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	THBS4	IDA		Human	PMID:16099885
Biological Process	GO:0034103	regulation of tissue remodeling	Thbs4	IMP		Mouse	MGI:MGI:5436396|PMID:22362893
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Thbs4	IMP		Mouse	MGI:MGI:5431143|PMID:22682248
Biological Process	GO:0035989	tendon development	thbs4b	IMP	ZFIN:ZDB-MRPHLNO-140905-1	Zfish	PMID:24941943
Biological Process	GO:0035989	tendon development	thbs4b	IGI	ZFIN:ZDB-GENO-080130-1,ZFIN:ZDB-MRPHLNO-140905-1	Zfish	PMID:24941943

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern