Thbs4
Gene Detail

Symbol Name ID

Thbs4 thrombospondin 4 MGI:1101779

Synonyms

TSP4, TSP-4

Feature Type

protein coding gene

Genetic Map

Chromosome 13

47.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr13:92751590-92794818 bp, - strand From VEGA annotation of GRCm38   43229 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Thbs4 ± 2 cM)

Protein SuperFamily: thrombospondin 3
Gene Tree: Thbs4

Human ortholog

THBS4 thrombospondin 4 NCBI Gene ID 7060
Human Synonyms: TSP4
Human Chr5:79331170-79379110 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a targeted allele exhibit increased sensitivity to cardiac pressure overload, including increased hypertrophy, decreased ejection fraction, decreased microvessle number, increased extracellular matrix deposition and increased fibrosis.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	cell adhesion, endothelial cell-cell adhesion, ...
Component	basement membrane, extracellular region, ...
Function	calcium ion binding, collagen binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (314)    Tissues (70)    Images (61)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	237
In situ reporter (knock in)	39
RT-PCR	38

cDNA source data(32)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(34) cDNA(33) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000036725 (Evidence)
Ensembl Gene Model	ENSMUSG00000021702 (Evidence)
Entrez Gene	21828 (Evidence)
UniGene	20865
DFCI	TC1580565
DoTS	DT.526185
NIA Mouse Gene Index	U035026
Consensus CDS Project	CCDS26684.1
International Mouse Knockout Project Status	Thbs4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036725	VEGA Gene Model | MGI Sequence Detail	43229	C57BL/6J
transcript	OTTMUST00000094148	VEGA | MGI Sequence Detail	3198	Not Applicable
polypeptide	OTTMUSP00000052302	VEGA | MGI Sequence Detail	963	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(230 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR001791	Laminin G domain
InterPro	IPR024665	Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
InterPro	IPR008859	Thrombospondin, C-terminal
InterPro	IPR003367	Thrombospondin, type 3-like repeat
InterPro	IPR017897	Thrombospondin, type 3 repeat
Protein Ontology	PR:000000132	thrombospondin-4

References

(Earliest) J:44447 Baumeister A, et al., Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis. J Cell Biol. 1997 Dec 1;139(5):1231-42
(Latest) J:187437 Frolova EG, et al., Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload. FASEB J. 2012 Jun;26(6):2363-73
All references(41)