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Thbs4 Gene Detail
Summary
  • Symbol
    Thbs4
  • Name
    thrombospondin 4
  • Synonyms
    TSP4, TSP-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101779
    NCBI Gene: 21828
  • Gene Overview
    MyGene.info: THBS4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:92751590-92794818 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 47.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    270 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101779
protein coding gene Chr13:92751586-92794818 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020820
protein coding gene Chr13:94078433-94123083 (-)
A/J MGP_AJ_G0020774
protein coding gene Chr13:90584075-90627523 (-)
AKR/J MGP_AKRJ_G0020747
protein coding gene Chr13:93321304-93365373 (-)
BALB/cJ MGP_BALBcJ_G0020770
protein coding gene Chr13:91226439-91269805 (-)
C3H/HeJ MGP_C3HHeJ_G0020564
protein coding gene Chr13:93036623-93080796 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021207
protein coding gene Chr13:96942490-96986572 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018774
protein coding gene Chr13:86505469-86548941 (-)
CAST/EiJ MGP_CASTEiJ_G0020083
protein coding gene Chr13:92291842-92339332 (-)
CBA/J MGP_CBAJ_G0020523
protein coding gene Chr13:100765216-100815102 (-)
DBA/2J MGP_DBA2J_G0020648
protein coding gene Chr13:90347602-90390827 (-)
FVB/NJ MGP_FVBNJ_G0020628
protein coding gene Chr13:89163227-89207406 (-)
LP/J MGP_LPJ_G0020721
protein coding gene Chr13:94191759-94236022 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020657
protein coding gene Chr13:101273973-101318879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021247
protein coding gene Chr13:92729003-92772160 (-)
PWK/PhJ MGP_PWKPhJ_G0019835
protein coding gene Chr13:89084369-89127725 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019659
protein coding gene Chr13:88996026-89041126 (-)
WSB/EiJ MGP_WSBEiJ_G0020140
protein coding gene Chr13:93214215-93261545 (-)



Homology
more
  • Human Ortholog
    THBS4, thrombospondin 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    THBS4, thrombospondin 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TSP4, TSP-4
  • Links
    NCBI Gene ID: 7060
    neXtProt AC: NX_P35443
    UniProt: P35443

  • Chr Location
    5q14.1; chr5:79991296-80083287 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit increased sensitivity to cardiac pressure overload, including increased hypertrophy, decreased ejection fraction, decreased microvessle number, increased extracellular matrix deposition and increased fibrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021702 Ensembl Gene Model | MGI Sequence Detail 43229 C57BL/6J ±  kb
    transcript ENSMUST00000022213 Ensembl | MGI Sequence Detail 3198 Not Applicable  
    polypeptide ENSMUSP00000022213 Ensembl | MGI Sequence Detail 963 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 35
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 14
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:264241 Brody MJ, et al., Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy. Mol Cell Biol. 2018 Apr 30;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory