Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes THBS1
  • Mouse genes Thbs1
  • Rat genes Thbs1
  • Zfish genes thbs1a,thbs1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Thbs1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070052	collagen V binding	THBS1	IDA		Human	PMID:6693501
Molecular Function	GO:0050840	extracellular matrix binding	Thbs1	IDA		Mouse	PMID:18757743
Molecular Function	GO:0005201	extracellular matrix structural constituent	THBS1	HDA		Human	PMID:28344315
Molecular Function	GO:0070051	fibrinogen binding	THBS1	IDA		Human	PMID:6693501
Molecular Function	GO:0017134	fibroblast growth factor binding	THBS1	IDA		Human	PMID:17996481
Molecular Function	GO:0001968	fibronectin binding	THBS1	IDA		Human	PMID:18042364
Molecular Function	GO:0001968	fibronectin binding	THBS1	IDA		Human	PMID:6693501
Molecular Function	GO:0008201	heparin binding	THBS1	IDA		Human	PMID:101549
Molecular Function	GO:0008201	heparin binding	THBS1	IDA		Human	PMID:8288588
Molecular Function	GO:0005178	integrin binding	THBS1	IMP		Human	PMID:17413041
Molecular Function	GO:0005178	integrin binding	THBS1	IMP		Human	PMID:18757424
Molecular Function	GO:0043236	laminin binding	THBS1	IDA		Human	PMID:6693501
Molecular Function	GO:0030169	low-density lipoprotein particle binding	THBS1	IDA		Human	PMID:6693501
Molecular Function	GO:0001786	phosphatidylserine binding	THBS1	IDA		Human	PMID:18940719
Molecular Function	GO:0005515	protein binding	THBS1	IPI	UniProtKB:P04196	Human	PMID:11134179
Molecular Function	GO:0005515	protein binding	THBS1	IPI	UniProtKB:P24593	Human	PMID:15700281
Molecular Function	GO:0005515	protein binding	THBS1	IPI	UniProtKB:P01137	Human	PMID:15864306
Molecular Function	GO:0005515	protein binding	THBS1	IPI	UniProtKB:P02751	Human	PMID:18042364
Molecular Function	GO:0005515	protein binding	THBS1	IPI	UniProtKB:O43852	Human	PMID:18688696
Molecular Function	GO:0005515	protein binding	THBS1	IPI	UniProtKB:P02751	Human	PMID:19542224
Molecular Function	GO:0005515	protein binding	THBS1	IPI	UniProtKB:Q15113	Human	PMID:24117177
Molecular Function	GO:0005515	protein binding	THBS1	IPI	UniProtKB:Q2FZB8	Human	PMID:26627825
Molecular Function	GO:0005515	protein binding	THBS1	IPI	UniProtKB:P09486	Human	PMID:3402455
Molecular Function	GO:0005515	protein binding	THBS1	IPI	UniProtKB:P00747	Human	PMID:6438154
Molecular Function	GO:0005515	protein binding	Thbs1	IPI	UniProtKB:F6VAN0	Mouse	MGI:MGI:5431143|PMID:22682248
Molecular Function	GO:0050431	transforming growth factor beta binding	Thbs1	IDA		Rat	PMID:10487979|RGD:2317966
Cellular Component	GO:0009986	cell surface	THBS1	IDA		Human	PMID:2435757
Cellular Component	GO:0009986	cell surface	THBS1	IDA		Human	PMID:3084490
Cellular Component	GO:0009986	cell surface	THBS1	IDA		Human	PMID:6777381
Cellular Component	GO:0062023	collagen-containing extracellular matrix	THBS1	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	THBS1	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	THBS1	HDA		Human	PMID:23979707
Cellular Component	GO:0062023	collagen-containing extracellular matrix	THBS1	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	THBS1	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Thbs1	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Thbs1	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Thbs1	HDA		Mouse	MGI:MGI:5582867|PMID:23658023
Cellular Component	GO:0005737	cytoplasm	Thbs1	IDA		Rat	PMID:16754856|RGD:2317944
Cellular Component	GO:0005783	endoplasmic reticulum	Thbs1	IDA		Mouse	MGI:MGI:5431143|PMID:22682248
Cellular Component	GO:0009897	external side of plasma membrane	THBS1	IDA		Human	PMID:6777381
Cellular Component	GO:0070062	extracellular exosome	THBS1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	THBS1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	THBS1	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	THBS1	HDA		Human	PMID:23533145
Cellular Component	GO:0031012	extracellular matrix	THBS1	IDA		Human	PMID:6341993
Cellular Component	GO:0005576	extracellular region	THBS1	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	THBS1	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	THBS1	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	THBS1	IDA		Human	PMID:26395742
Cellular Component	GO:0005615	extracellular space	THBS1	IDA		Human	PMID:6777381
Cellular Component	GO:0005615	extracellular space	Thbs1	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Thbs1	IDA		Mouse	PMID:12498716
Cellular Component	GO:0005615	extracellular space	Thbs1	IDA		Rat	PMID:16754856|RGD:2317944
Cellular Component	GO:0005577	fibrinogen complex	THBS1	IDA		Human	PMID:3997886
Cellular Component	GO:0031091	platelet alpha granule	THBS1	IDA		Human	PMID:6777381
Cellular Component	GO:0016529	sarcoplasmic reticulum	Thbs1	IDA		Mouse	MGI:MGI:5431143|PMID:22682248
Cellular Component	GO:0030141	secretory granule	THBS1	IDA		Human	PMID:101549
Biological Process	GO:0048266	behavioral response to pain	Thbs1	IMP		Mouse	MGI:MGI:5516179|PMID:22745497
Biological Process	GO:0048514	blood vessel morphogenesis	Thbs1	IGI	MGI:MGI:97297	Mouse	PMID:20026598
Biological Process	GO:0016477	cell migration	THBS1	IDA		Human	PMID:18555217
Biological Process	GO:0071363	cellular response to growth factor stimulus	Thbs1	IEP		Rat	PMID:15831915|RGD:2317962
Biological Process	GO:0071732	cellular response to nitric oxide	Thbs1	IMP	MGI:MGI:2154534	Mouse	PMID:16150726
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Thbs1	IEP		Rat	PMID:15831915|RGD:2317962
Biological Process	GO:0002544	chronic inflammatory response	THBS1	IEP		Human	PMID:18674744
Biological Process	GO:0003197	endocardial cushion development	Thbs1	IGI	MGI:MGI:97297	Mouse	PMID:20026598
Biological Process	GO:0043652	engulfment of apoptotic cell	THBS1	IDA		Human	PMID:16882710
Biological Process	GO:0003417	growth plate cartilage development	Thbs1	IGI	MGI:MGI:88469	Mouse	PMID:18467703
Biological Process	GO:0003417	growth plate cartilage development	Thbs1	IGI	MGI:MGI:88465	Mouse	PMID:18467703
Biological Process	GO:0003417	growth plate cartilage development	Thbs1	IGI	MGI:MGI:98739	Mouse	PMID:18467703
Biological Process	GO:0003417	growth plate cartilage development	Thbs1	IMP	MGI:MGI:2154534	Mouse	PMID:18467703
Biological Process	GO:0006955	immune response	THBS1	IEP		Human	PMID:18674744
Biological Process	GO:0006954	inflammatory response	THBS1	IDA		Human	PMID:23144964
Biological Process	GO:0006954	inflammatory response	Thbs1	IMP	MGI:MGI:2154534	Mouse	PMID:15963261
Biological Process	GO:0070487	monocyte aggregation	Thbs1	IMP		Mouse	PMID:28228282
Biological Process	GO:0016525	negative regulation of angiogenesis	THBS1	IDA		Human	PMID:16150726
Biological Process	GO:0016525	negative regulation of angiogenesis	THBS1	IDA		Human	PMID:17596205
Biological Process	GO:0016525	negative regulation of angiogenesis	THBS1	IDA		Human	PMID:17996481
Biological Process	GO:0016525	negative regulation of angiogenesis	THBS1	IDA		Human	PMID:18726995
Biological Process	GO:0016525	negative regulation of angiogenesis	THBS1	IMP		Human	PMID:24177325
Biological Process	GO:0016525	negative regulation of angiogenesis	Thbs1	IMP	MGI:MGI:2154534	Mouse	PMID:16150726
Biological Process	GO:0016525	negative regulation of angiogenesis	Thbs1	IDA		Mouse	PMID:12498716
Biological Process	GO:0016525	negative regulation of angiogenesis	Thbs1	IDA		Rat	PMID:18772338|RGD:2307224
Biological Process	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	THBS1	IDA		Human	PMID:16882710
Biological Process	GO:0043066	negative regulation of apoptotic process	THBS1	IDA		Human	PMID:18653767
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	THBS1	IDA		Human	PMID:18555217
Biological Process	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	THBS1	IMP		Human	PMID:25660232
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	THBS1	IMP		Human	PMID:25660232
Biological Process	GO:0008285	negative regulation of cell population proliferation	THBS1	IDA		Human	PMID:17596205
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	THBS1	IDA		Human	PMID:16150726
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	THBS1	IDA		Human	PMID:17416590
Biological Process	GO:0010754	negative regulation of cGMP-mediated signaling	THBS1	IDA		Human	PMID:17416590
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	THBS1	IDA		Human	PMID:18653767
Biological Process	GO:0002605	negative regulation of dendritic cell antigen processing and presentation	THBS1	IDA		Human	PMID:16882710
Biological Process	GO:2001027	negative regulation of endothelial cell chemotaxis	THBS1	IDA		Human	PMID:16150726
Biological Process	GO:0010596	negative regulation of endothelial cell migration	THBS1	IDA		Human	PMID:18555217
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	THBS1	IDA		Human	PMID:16150726
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	THBS1	IMP		Human	PMID:17413041
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	THBS1	IDA		Human	PMID:17996481
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	Thbs1	IMP	MGI:MGI:2154534	Mouse	PMID:16150726
Biological Process	GO:0051918	negative regulation of fibrinolysis	THBS1	IDA		Human	PMID:6438154
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	THBS1	IDA		Human	PMID:17996481
Biological Process	GO:0032695	negative regulation of interleukin-12 production	THBS1	IDA		Human	PMID:16882710
Biological Process	GO:0010748	negative regulation of long-chain fatty acid import across plasma membrane	THBS1	IDA		Human	PMID:17416590
Biological Process	GO:0010751	negative regulation of nitric oxide mediated signal transduction	THBS1	IDA		Human	PMID:16150726
Biological Process	GO:0010751	negative regulation of nitric oxide mediated signal transduction	THBS1	IDA		Human	PMID:17416590
Biological Process	GO:0010757	negative regulation of plasminogen activation	THBS1	IDA		Human	PMID:6438154
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	THBS1	IGI	RNAcentral:URS00001D69F6_9606	Human	PMID:28124060
Biological Process	GO:0003151	outflow tract morphogenesis	Thbs1	IGI	MGI:MGI:97297	Mouse	PMID:20026598
Biological Process	GO:0018149	peptide cross-linking	THBS1	IDA		Human	PMID:3997886
Biological Process	GO:0045766	positive regulation of angiogenesis	THBS1	IMP		Human	PMID:17413041
Biological Process	GO:0045766	positive regulation of angiogenesis	THBS1	IMP		Human	PMID:17879962
Biological Process	GO:0030194	positive regulation of blood coagulation	THBS1	IDA		Human	PMID:3997886
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	THBS1	IDA		Human	PMID:18555217
Biological Process	GO:0030335	positive regulation of cell migration	THBS1	IDA		Human	PMID:15700281
Biological Process	GO:0030335	positive regulation of cell migration	THBS1	IMP		Human	PMID:17413041
Biological Process	GO:0008284	positive regulation of cell population proliferation	THBS1	IDA		Human	PMID:24615654
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Thbs1	IDA		Mouse	PMID:18757743
Biological Process	GO:0050921	positive regulation of chemotaxis	THBS1	IDA		Human	PMID:18555217
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	THBS1	IDA		Human	PMID:18726995
Biological Process	GO:0010595	positive regulation of endothelial cell migration	THBS1	IDA		Human	PMID:18555217
Biological Process	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	THBS1	IDA		Human	PMID:18726995
Biological Process	GO:0010763	positive regulation of fibroblast migration	THBS1	IDA		Human	PMID:18555217
Biological Process	GO:0043032	positive regulation of macrophage activation	THBS1	IDA		Human	PMID:18757424
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	Thbs1	IMP		Mouse	MGI:MGI:4412437|PMID:18757424
Biological Process	GO:0043406	positive regulation of MAP kinase activity	THBS1	IMP		Human	PMID:17413041
Biological Process	GO:0042327	positive regulation of phosphorylation	THBS1	IMP		Human	PMID:17413041
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	THBS1	IDA		Human	PMID:18653767
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	THBS1	IDA		Human	PMID:18757424
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	THBS1	IDA		Human	PMID:24615654
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	Thbs1	IMP		Rat	PMID:17640965|RGD:2317942
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	THBS1	IDA		Human	PMID:18555217
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Thbs1	IMP		Mouse	MGI:MGI:1270011|PMID:9657149
Biological Process	GO:0045727	positive regulation of translation	THBS1	IDA		Human	PMID:15700281
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	THBS1	IDA		Human	PMID:18726995
Biological Process	GO:0051592	response to calcium ion	THBS1	IDA		Human	PMID:18757424
Biological Process	GO:0051592	response to calcium ion	THBS1	IDA		Human	PMID:6777381
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Thbs1	IMP		Mouse	MGI:MGI:5431143|PMID:22682248
Biological Process	GO:0009749	response to glucose	THBS1	IDA		Human	PMID:18096704
Biological Process	GO:0032026	response to magnesium ion	THBS1	IDA		Human	PMID:6777381
Biological Process	GO:0009612	response to mechanical stimulus	Thbs1	IMP		Rat	PMID:18772338|RGD:2307224
Biological Process	GO:0033574	response to testosterone	Thbs1	IEP		Rat	PMID:15665307|RGD:2317964
Biological Process	GO:0009410	response to xenobiotic stimulus	THBS1	IEP		Human	PMID:19738618
Biological Process	GO:0002040	sprouting angiogenesis	THBS1	IMP		Human	PMID:17879962

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern