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Thbs1
Gene Detail
Symbol

Name
ID
Thbs1
thrombospondin 1
MGI:98737
STS
Synonyms
tbsp1, Thbs-1, TSP1, TSP-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
59.34 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr2:118111876-118127133 bp, + strand
From VEGA annotation of GRCm38

  15258 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31142  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: THBS1
Protein SuperFamily: thrombospondin 1/2
Gene Tree: Thbs1

Human
homologs
THBS1, thrombospondin 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7057
neXtProt AC: NX_P07996

Human Synonyms: THBS, THBS-1, TSP, TSP1, TSP-1

Human Chr (Location): 15q15; chr15:39581079-39597467 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice show partial prenatal lethality, lordosis, kyphosis, leukocytosis, multiorgan inflammation, lung hemorrhage, pneumonia, resistance to radiation and ischemic injury, altered blood pressure and vasoactive stress responses, eye pathology, and corneal and lacrimal gland dysfunction.
 
Human Diseases Modeled in Mice Using Thbs1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Thbs1 interacts with 370 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (94 annotations)
Process activation of MAPK activity, behavioral response to pain, ...
Component cell surface, cytoplasm, ...
Function calcium ion binding, collagen V binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (326)    Tissues (114)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 276
Northern blot 28
RT-PCR 5
cDNA source data(412)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase thbs1    NEW 
Molecular
reagents
All nucleic(426) Genomic(5) cDNA(416) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000015240 (Evidence)
Ensembl Gene Model ENSMUSG00000040152 (Evidence)
Entrez Gene 21825 (Evidence)
UniGene 4159
DFCI TC1573966, TC1586572
DoTS DT.101164334, DT.40178632, DT.94226858
NIA Mouse Gene Index U002275
Consensus CDS Project CCDS38200.1
International Mouse Phenotyping Consortium Status Thbs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015240 VEGA Gene Model | MGI Sequence Detail 15258 C57BL/6J ±  kb
transcript OTTMUST00000036100 VEGA | MGI Sequence Detail 5848 Not Applicable 
polypeptide OTTMUSP00000016220 VEGA | MGI Sequence Detail 1171 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(4) UniProt(6)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR001791 Laminin G domain
InterPro IPR008859 Thrombospondin, C-terminal
InterPro IPR000884 Thrombospondin, type 1 repeat
InterPro IPR003367 Thrombospondin, type 3-like repeat
InterPro IPR017897 Thrombospondin, type 3 repeat
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000000129 thrombospondin-1
References
(Earliest) J:10470 Jaffe E, et al., Mapping of the thrombospondin gene to human chromosome 15 and mouse chromosome 2 by in situ hybridization. Genomics. 1990 May;7(1):123-6
(Latest) J:220781 Prakash P, et al., Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice. Blood. 2015 Jan 8;125(2):399-406
All references(194)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15083, MGD-MRK-15086

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory