Thbs1
Gene Detail

Symbol Name ID

Thbs1 thrombospondin 1 MGI:98737

STS

D2Mit62

Synonyms

tbsp1, Thbs-1, TSP1, TSP-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

59.34 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(25)

Sequence Map

Chr2:118111876-118127133 bp, + strand From VEGA annotation of GRCm38   15258 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31142  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: thrombospondin 1/2
Gene Tree: Thbs1

Human homologs

Human Homolog		THBS1, thrombospondin 1
NCBI Gene ID		7057
neXtProt AC		NX_P07996
Human Synonyms		THBS, THBS-1, TSP, TSP1, TSP-1
Human Chr (Location)		15q15; chr15:39873280-39889668 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous null mice show partial prenatal lethality, lordosis, kyphosis, leukocytosis, multiorgan inflammation, lung hemorrhage, pneumonia, resistance to radiation and ischemic injury, altered blood pressure and vasoactive stress responses, eye pathology, and corneal and lacrimal gland dysfunction.

 
Human Diseases Modeled Using Mouse Thbs1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	activation of MAPK activity, blood vessel morphogenesis, ...
Component	external side of plasma membrane, extracellular matrix, ...
Function	calcium ion binding, collagen V binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (311)    Tissues (98)    Images (39)
Theiler Stages: 11, 15, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	276
Northern blot	28
RT-PCR	5

cDNA source data(407)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(421) Genomic(5) cDNA(411) Primer pair(4) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000015240 (Evidence)
Ensembl Gene Model	ENSMUSG00000040152 (Evidence)
Entrez Gene	21825 (Evidence)
UniGene	4159
DFCI	TC1573966, TC1586572
DoTS	DT.101164334, DT.40178632, DT.94226858
NIA Mouse Gene Index	U002275
Consensus CDS Project	CCDS38200.1
International Mouse Knockout Project Status	Thbs1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015240	VEGA Gene Model | MGI Sequence Detail	15258	C57BL/6J
transcript	OTTMUST00000036100	VEGA | MGI Sequence Detail	5848	Not Applicable
polypeptide	OTTMUSP00000016220	VEGA | MGI Sequence Detail	1171	Not Applicable

All sequences(59) RefSeq(2) UniProt(6)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(107 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR001791	Laminin G domain
InterPro	IPR008859	Thrombospondin, C-terminal
InterPro	IPR000884	Thrombospondin, type 1 repeat
InterPro	IPR003367	Thrombospondin, type 3-like repeat
InterPro	IPR017897	Thrombospondin, type 3 repeat
InterPro	IPR001007	von Willebrand factor, type C
Protein Ontology	PR:000000129	thrombospondin-1

References

(Earliest) J:10470 Jaffe E, et al., Mapping of the thrombospondin gene to human chromosome 15 and mouse chromosome 2 by in situ hybridization. Genomics. 1990 May;7(1):123-6
(Latest) J:194125 Shibahara K, et al., Production of gastrointestinal tumors in mice by modulating latent TGF-beta1 activation. Cancer Res. 2013 Jan 1;73(1):459-68
All references(164)

Other accession IDs

MGD-MRK-15083, MGD-MRK-15086