Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TBXT
  • Mouse genes T
  • Rat genes Tbxt
  • Zfish genes tbxta,tbxtb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set T

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	tbxta	IDA		Zfish	PMID:19158186
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	TBXT	IDA		Human	PMID:21632880
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	T	IDA		Mouse	PMID:7588606
Molecular Function	GO:0005515	protein binding	T	IPI	UniProtKB:Q9WUI0	Mouse	MGI:MGI:5448510|PMID:22164283
Molecular Function	GO:0005515	protein binding	T	IPI	PR:P42227	Mouse	PMID:16801560
Molecular Function	GO:0005515	protein binding	tbxta	IPI	UniProtKB:P79734	Zfish	PMID:15590746
Molecular Function	GO:0005515	protein binding	tbxta	IPI	UniProtKB:O42606	Zfish	PMID:15590746
Molecular Function	GO:0005515	protein binding	tbxta	IPI	UniProtKB:Q90467	Zfish	PMID:15590746
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TBXT	IDA		Human	PMID:21632880
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	T	IDA		Mouse	MGI:MGI:5448510|PMID:22164283
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	TBXT	IPI	UniProtKB:Q9H2W2	Human	PMID:22164283
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	T	IPI	UniProtKB:Q02591|UniProtKB:Q9WUI0	Mouse	MGI:MGI:5448510|PMID:22164283
Molecular Function	GO:0043565	sequence-specific DNA binding	T	IDA		Mouse	PMID:11071760
Molecular Function	GO:0043565	sequence-specific DNA binding	T	IDA		Mouse	PMID:16801560
Molecular Function	GO:0043565	sequence-specific DNA binding	T	IDA		Mouse	PMID:8344258
Molecular Function	GO:0043565	sequence-specific DNA binding	T	IDA		Mouse	PMID:7588606
Molecular Function	GO:0043565	sequence-specific DNA binding	tbxta	IDA		Zfish	PMID:23950494
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TBXT	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	tbxta	IDA		Zfish	PMID:19158186
Cellular Component	GO:0000785	chromatin	TBXT	IDA		Human	PMID:21632880
Cellular Component	GO:0000785	chromatin	T	IDA		Mouse	MGI:MGI:5448510|PMID:22164283
Cellular Component	GO:0000785	chromatin	T	IMP		Mouse	MGI:MGI:5307952|PMID:21632880
Cellular Component	GO:0000785	chromatin	tbxta	IDA		Zfish	PMID:28658625
Cellular Component	GO:0005737	cytoplasm	T	IDA		Mouse	PMID:16835439
Cellular Component	GO:0005654	nucleoplasm	TBXT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TBXT	IDA		Human	PMID:22611028
Cellular Component	GO:0005634	nucleus	TBXT	IDA		Human	PMID:24253444
Cellular Component	GO:0005634	nucleus	T	IDA		Mouse	PMID:8293872
Cellular Component	GO:0005634	nucleus	T	IDA		Mouse	PMID:7588606
Cellular Component	GO:0005634	nucleus	T	IDA		Mouse	PMID:16801560
Cellular Component	GO:0005634	nucleus	T	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005634	nucleus	tbxta	IDA		Zfish	PMID:7600949
Cellular Component	GO:0005634	nucleus	tbxta	IDA		Zfish	PMID:19369398
Cellular Component	GO:0005634	nucleus	tbxta	IDA		Zfish	PMID:7600961
Cellular Component	GO:0005634	nucleus	tbxta	IDA		Zfish	PMID:1295726
Biological Process	GO:0009653	anatomical structure morphogenesis	T	IMP	MGI:MGI:1856185	Mouse	PMID:16835439
Biological Process	GO:0009952	anterior/posterior pattern specification	T	IMP	MGI:MGI:3042261	Mouse	PMID:15384171
Biological Process	GO:0009952	anterior/posterior pattern specification	T	IMP	MGI:MGI:3042264	Mouse	PMID:15384171
Biological Process	GO:0009952	anterior/posterior pattern specification	T	IMP	MGI:MGI:3042262	Mouse	PMID:15384171
Biological Process	GO:0060349	bone morphogenesis	T	IGI	MGI:MGI:1927715	Mouse	PMID:11071760
Biological Process	GO:0060379	cardiac muscle cell myoblast differentiation	TBXT	IDA		Human	PMID:21632880
Biological Process	GO:0060379	cardiac muscle cell myoblast differentiation	T	IMP		Mouse	MGI:MGI:5307952|PMID:21632880
Biological Process	GO:0008283	cell population proliferation	T	IMP	MGI:MGI:1856185	Mouse	PMID:16835439
Biological Process	GO:0071300	cellular response to retinoic acid	Tbxt	IEP		Rat	PMID:20507357|RGD:8693647
Biological Process	GO:0060028	convergent extension involved in axis elongation	tbxta	IGI	ZFIN:ZDB-GENO-080512-4	Zfish	PMID:14660439
Biological Process	GO:0060028	convergent extension involved in axis elongation	tbxta	IGI	ZFIN:ZDB-GENO-080512-6	Zfish	PMID:14660439
Biological Process	GO:0072045	convergent extension involved in nephron morphogenesis	tbxta	IMP	ZFIN:ZDB-GENO-980202-1335	Zfish	PMID:23860396
Biological Process	GO:0072045	convergent extension involved in nephron morphogenesis	tbxta	IMP	ZFIN:ZDB-GENO-970731-32	Zfish	PMID:23860396
Biological Process	GO:0061371	determination of heart left/right asymmetry	T	IMP	MGI:MGI:1856184	Mouse	PMID:10349618
Biological Process	GO:0061371	determination of heart left/right asymmetry	tbxta	IMP	ZFIN:ZDB-GENO-970730-2	Zfish	PMID:8660880
Biological Process	GO:0035462	determination of left/right asymmetry in diencephalon	tbxta	IMP	ZFIN:ZDB-MRPHLNO-050221-3	Zfish	PMID:19363156
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	tbxta	IMP	ZFIN:ZDB-GENO-970730-2	Zfish	PMID:12702646
Biological Process	GO:0007368	determination of left/right symmetry	tbxta	IMP	ZFIN:ZDB-GENO-970730-2	Zfish	PMID:12571098
Biological Process	GO:0007368	determination of left/right symmetry	tbxta	IMP	ZFIN:ZDB-GENO-970730-2	Zfish	PMID:11144351
Biological Process	GO:0007368	determination of left/right symmetry	tbxta	IMP	ZFIN:ZDB-MRPHLNO-050221-3	Zfish	PMID:15694307
Biological Process	GO:0007368	determination of left/right symmetry	tbxta	IMP	ZFIN:ZDB-GENO-970731-32	Zfish	PMID:10903181
Biological Process	GO:0007368	determination of left/right symmetry	tbxta	IMP		Zfish	PMID:12645931
Biological Process	GO:0007368	determination of left/right symmetry	tbxta	IMP	ZFIN:ZDB-GENO-980202-1335	Zfish	PMID:9334285
Biological Process	GO:0048565	digestive tract development	tbxta	IGI	ZFIN:ZDB-GENE-990615-5	Zfish	PMID:28658625
Biological Process	GO:0003143	embryonic heart tube morphogenesis	tbxta	IMP	ZFIN:ZDB-GENO-980202-1335	Zfish	PMID:9334285
Biological Process	GO:0048706	embryonic skeletal system development	T	IMP	MGI:MGI:1857760	Mouse	PMID:8293872
Biological Process	GO:0001947	heart looping	tbxta	IMP	ZFIN:ZDB-GENO-980202-1335	Zfish	PMID:9334285
Biological Process	GO:0003007	heart morphogenesis	TBXT	IDA		Human	PMID:21632880
Biological Process	GO:0070121	Kupffer's vesicle development	tbxta	IMP	ZFIN:ZDB-GENO-970730-2	Zfish	PMID:8681803
Biological Process	GO:0001889	liver development	tbxta	IGI	ZFIN:ZDB-GENE-990615-5	Zfish	PMID:28658625
Biological Process	GO:0007498	mesoderm development	T	IMP	MGI:MGI:1857760	Mouse	PMID:8293872
Biological Process	GO:0007498	mesoderm development	tbxta	IMP	ZFIN:ZDB-GENO-970730-2,ZFIN:ZDB-GENO-970731-32	Zfish	PMID:7600949
Biological Process	GO:0007498	mesoderm development	tbxta	IGI	ZFIN:ZDB-GENO-970731-32,ZFIN:ZDB-MRPHLNO-051107-1,ZFIN:ZDB-MRPHLNO-051107-2	Zfish	PMID:16162652
Biological Process	GO:0007498	mesoderm development	tbxta	IGI	ZFIN:ZDB-GENO-140822-4	Zfish	PMID:12091302
Biological Process	GO:0001707	mesoderm formation	tbxta	IGI	ZFIN:ZDB-GENO-070131-1	Zfish	PMID:9053309
Biological Process	GO:0007509	mesoderm migration involved in gastrulation	T	IMP	MGI:MGI:1857760	Mouse	PMID:7720590
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	T	IDA		Mouse	MGI:MGI:5448510|PMID:22164283
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	T	IDA		Mouse	MGI:MGI:5448510|PMID:22164283
Biological Process	GO:0001839	neural plate morphogenesis	T	IMP	MGI:MGI:3042264	Mouse	PMID:15384171
Biological Process	GO:0001843	neural tube closure	T	IMP	MGI:MGI:1856158	Mouse	PMID:16835439
Biological Process	GO:0060034	notochord cell differentiation	tbxta	IMP	ZFIN:ZDB-GENO-970730-2	Zfish	PMID:8681803
Biological Process	GO:0030903	notochord development	T	IMP	MGI:MGI:1856185	Mouse	PMID:8155581
Biological Process	GO:0030903	notochord development	T	IMP	MGI:MGI:3042264	Mouse	PMID:15384171
Biological Process	GO:0030903	notochord development	T	IMP	MGI:MGI:1857760	Mouse	PMID:8293872
Biological Process	GO:0030903	notochord development	tbxta	IMP	ZFIN:ZDB-GENO-120224-3	Zfish	PMID:9007234
Biological Process	GO:0030903	notochord development	tbxta	IMP	ZFIN:ZDB-MRPHLNO-071130-1	Zfish	PMID:17717538
Biological Process	GO:0030903	notochord development	tbxta	IMP	ZFIN:ZDB-GENO-120224-4	Zfish	PMID:9007234
Biological Process	GO:0014028	notochord formation	T	IMP	MGI:MGI:1856184	Mouse	PMID:7589801
Biological Process	GO:0014028	notochord formation	tbxta	IMP	ZFIN:ZDB-GENO-980202-1335	Zfish	PMID:9007233
Biological Process	GO:0031016	pancreas development	tbxta	IGI	ZFIN:ZDB-GENE-990615-5	Zfish	PMID:28658625
Biological Process	GO:0007341	penetration of zona pellucida	T	IMP	MGI:MGI:1856722	Mouse	PMID:7883069
Biological Process	GO:0007341	penetration of zona pellucida	T	IMP	MGI:MGI:1856570	Mouse	PMID:7883069
Biological Process	GO:0008284	positive regulation of cell population proliferation	T	IMP	MGI:MGI:1856185	Mouse	PMID:16835439
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TBXT	IDA		Human	PMID:21632880
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	T	IMP		Mouse	MGI:MGI:5307952|PMID:21632880
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	T	IGI	MGI:MGI:96787	Mouse	PMID:16801560
Biological Process	GO:0036342	post-anal tail morphogenesis	T	IMP	MGI:MGI:1856562	Mouse	PMID:924142
Biological Process	GO:0036342	post-anal tail morphogenesis	T	IMP		Mouse	PMID:20350929
Biological Process	GO:0036342	post-anal tail morphogenesis	T	IGI	MGI:MGI:1927715	Mouse	PMID:11071760
Biological Process	GO:0036342	post-anal tail morphogenesis	T	IMP	MGI:MGI:1857760	Mouse	PMID:8293872
Biological Process	GO:0036342	post-anal tail morphogenesis	T	IMP	MGI:MGI:1856737	Mouse	PMID:924142
Biological Process	GO:0036342	post-anal tail morphogenesis	T	IMP	MGI:MGI:1857760	Mouse	PMID:7720590
Biological Process	GO:0036342	post-anal tail morphogenesis	tbxta	IMP	ZFIN:ZDB-GENO-980202-1335	Zfish	PMID:17717538
Biological Process	GO:0036342	post-anal tail morphogenesis	tbxta	IMP	ZFIN:ZDB-MRPHLNO-071130-1	Zfish	PMID:17717538
Biological Process	GO:0036342	post-anal tail morphogenesis	tbxta	IMP	ZFIN:ZDB-GENO-161013-9	Zfish	PMID:27153483
Biological Process	GO:0035775	pronephric glomerulus morphogenesis	tbxta	IMP	ZFIN:ZDB-GENO-970731-32	Zfish	PMID:23860396
Biological Process	GO:0035775	pronephric glomerulus morphogenesis	tbxta	IMP	ZFIN:ZDB-GENO-980202-1335	Zfish	PMID:23860396
Biological Process	GO:2000223	regulation of BMP signaling pathway involved in heart jogging	tbxta	IMP	ZFIN:ZDB-GENO-980202-1335	Zfish	PMID:9334285
Biological Process	GO:0042663	regulation of endodermal cell fate specification	tbxta	IGI	ZFIN:ZDB-GENE-990615-5	Zfish	PMID:28658625
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	T	IDA		Mouse	PMID:7588606
Biological Process	GO:0022414	reproductive process	T	IMP	MGI:MGI:1856562	Mouse	PMID:924142
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	T	IDA		Mouse	PMID:18462699
Biological Process	GO:0060395	SMAD protein signal transduction	T	IDA		Mouse	PMID:9420335
Biological Process	GO:0061053	somite development	tbxta	IMP	ZFIN:ZDB-GENO-980202-1335	Zfish	PMID:9007233
Biological Process	GO:0061053	somite development	tbxta	IGI	ZFIN:ZDB-GENO-070131-1	Zfish	PMID:9053309
Biological Process	GO:0001757	somite specification	tbxta	IMP	ZFIN:ZDB-MRPHLNO-050221-3	Zfish	PMID:32345657
Biological Process	GO:0001756	somitogenesis	T	IMP	MGI:MGI:1857760	Mouse	PMID:8293872
Biological Process	GO:0001756	somitogenesis	T	IMP	MGI:MGI:3042264	Mouse	PMID:15384171
Biological Process	GO:0001756	somitogenesis	T	IMP	MGI:MGI:1856158	Mouse	PMID:16835439
Biological Process	GO:0001756	somitogenesis	tbxta	IMP	ZFIN:ZDB-MRPHLNO-071130-1	Zfish	PMID:17717538
Biological Process	GO:0010159	specification of animal organ position	tbxta	IMP	ZFIN:ZDB-GENO-970731-32	Zfish	PMID:10903181
Biological Process	GO:0060063	Spemann organizer formation at the embryonic shield	tbxta	IMP	ZFIN:ZDB-GENO-970731-32	Zfish	PMID:32345657
Biological Process	GO:0006366	transcription by RNA polymerase II	T	IGI	MGI:MGI:96787	Mouse	PMID:16801560
Biological Process	GO:0001570	vasculogenesis	T	IMP	MGI:MGI:1856185	Mouse	PMID:16835439

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern