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T
Gene Detail
Symbol

Name
ID
T
brachyury
MGI:98472
Synonyms
Bra, T1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
4.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(105)
Sequence Map
Chr17:8434423-8442496 bp, + strand
From VEGA annotation of GRCm38

  8074 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2393  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: T
Protein SuperFamily: mouse gene T protein
Gene Tree: T

Human
homologs
T, T brachyury transcription factor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6862
neXtProt AC: NX_O15178

Human Synonyms: SAVA, TFT

Human Chr (Location): 6q27; chr6:166157656-166168669 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human T

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Chemically and radiation induced(6) Chemically induced (ENU)(6) Radiation induced(11) Spontaneous(15) Targeted(4) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice die during embryonice development. Heterozygous mice have skeletal abnormalities. On specific genetic backgrounds, some alleles cause partial or complete sex-reversal of chromosomally XY mice.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
T interacts with 97 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process anatomical structure morphogenesis, anterior/posterior pattern specification, ...
Component chromatin, cytoplasm, ...
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (464 records)
Data Summary: Results (1058)    Tissues (328)    Images (382)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 184
RNA in situ 672
In situ reporter (knock in) 9
Northern blot 19
Western blot 4
RT-PCR 170
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA T ; Xenbase t ; ZFIN ta, tb    NEW 
Molecular
reagents
All nucleic(105) Genomic(4) cDNA(47) Primer pair(20) Other(34)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026263 (Evidence)
Ensembl Gene Model ENSMUSG00000062327 (Evidence)
Entrez Gene 20997 (Evidence)
UniGene 913
DFCI TC1586132
DoTS DT.489914
NIA Mouse Gene Index U017472
Consensus CDS Project CCDS28383.1
International Mouse Phenotyping Consortium Status T
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026263 VEGA Gene Model | MGI Sequence Detail 8074 C57BL/6J ±  kb
transcript OTTMUST00000064950 VEGA | MGI Sequence Detail 2046 Not Applicable 
polypeptide OTTMUSP00000032305 VEGA | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(23) UniProt(4)
Polymorphisms
RFLP(5) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR002070 Transcription factor, Brachyury
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000016001 brachyury protein
References
(Earliest) J:14909 Dobrovolskaia-Zavadskaia N, Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere (facteur) hereditaire "non-viable". C R Seances Soc Biol Fil. 1927;97:114-16
(Latest) J:222248 Fossat N, et al., Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo. Development. 2015 Jun 1;142(11):2069-79
All references(698)
Other
accession IDs
MGD-MRK-11865, MGD-MRK-11883, MGD-MRK-14695, MGD-MRK-2096, MGI:2152887, MGI:2152888

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory