T
Gene Detail

Symbol Name ID

T brachyury MGI:98472

Synonyms

Bra, T1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

4.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(105)

Sequence Map

Chr17:8434423-8442496 bp, + strand From VEGA annotation of GRCm38   8074 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2393  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: mouse gene T protein
Gene Tree: T

Human homologs

Human Homolog		T, T, brachyury homolog (mouse)
NCBI Gene ID		6862
neXtProt AC		NX_O15178
Human Synonyms		TFT
Human Chr (Location)		6q27; chr6:166571144-166582157 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human T

Alleles and phenotypes

All alleles(41) : Targeted(2) Transgenic(1) Spontaneous(15) Chemically induced(12) Radiation induced(17)
 

Homozygous mice die during embryonice development. Heterozygous mice have skeletal abnormalities. On specific genetic backgrounds, some alleles cause partial or complete sex-reversal of chromosomally XY mice.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (54 annotations)

Process	anatomical structure morphogenesis, anterior/posterior pattern specification, ...
Component	chromatin, cytoplasm, ...
Function	DNA binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (420 records)
Data Summary: Results (977)    Tissues (328)    Images (311)
Theiler Stages: 2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	181
RNA in situ	596
Northern blot	19
Western blot	4
RT-PCR	177

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(92) Genomic(4) cDNA(43) Primer pair(18) Other(27)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026263 (Evidence)
Ensembl Gene Model	ENSMUSG00000062327 (Evidence)
Entrez Gene	20997 (Evidence)
UniGene	913
DFCI	TC1586132
DoTS	DT.489914
NIA Mouse Gene Index	U017472
Consensus CDS Project	CCDS28383.1
International Mouse Knockout Project Status	T

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026263	VEGA Gene Model | MGI Sequence Detail	8074	C57BL/6J
transcript	OTTMUST00000064950	VEGA | MGI Sequence Detail	2046	Not Applicable
polypeptide	OTTMUSP00000032305	VEGA | MGI Sequence Detail	436	Not Applicable

All sequences(27) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(5) : SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR002070	Transcription factor, Brachyury
InterPro	IPR001699	Transcription factor, T-box
InterPro	IPR018186	Transcription factor, T-box, conserved site
Protein Ontology	PR:000016001	brachyury protein

References

(Earliest) J:14909 Dobrovolskaia-Zavadskaia N, Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere (facteur) hereditaire "non-viable". C R Seances Soc Biol Fil. 1927;97:114-16
(Latest) J:195133 Semba K, et al., Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice. PLoS Genet. 2013 Feb;9(2):e1003204
All references(654)

Other accession IDs

MGD-MRK-11865, MGD-MRK-11883, MGD-MRK-14695, MGD-MRK-2096, MGI:2152887, MGI:2152888