About   Help   FAQ
T
Gene Detail
Symbol

Name
ID
T
brachyury
MGI:98472
Synonyms
Bra, T1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
4.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(105)
Sequence Map
Chr17:8434423-8442496 bp, + strand
From VEGA annotation of GRCm38

  8074 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: mouse gene T protein
Gene Tree: T
Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Chemically and radiation induced(6) Chemically induced (ENU)(6) Radiation induced(11) Spontaneous(15) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice die during embryonice development. Heterozygous mice have skeletal abnormalities. On specific genetic backgrounds, some alleles cause partial or complete sex-reversal of chromosomally XY mice.
 
Phenotype Images(2)
Interactions
T interacts with 97 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process anatomical structure morphogenesis, anterior/posterior pattern specification, ...
Component chromatin, cytoplasm, ...
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (448 records)
Data Summary: Results (1054)    Tissues (328)    Images (371)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 184
RNA in situ 668
In situ reporter (knock in) 9
Northern blot 19
Western blot 4
RT-PCR 170
cDNA source data(37)
External Resources: Allen Institute   Expression Atlas
Molecular
reagents
All nucleic(102) Genomic(4) cDNA(46) Primer pair(19) Other(33)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026263 (Evidence)
Ensembl Gene ModelENSMUSG00000062327 (Evidence)
Entrez Gene20997, 102637342
UniGene913
DFCITC1586132
DoTSDT.489914
NIA Mouse Gene IndexU017472
Consensus CDS ProjectCCDS28383.1
International Mouse Knockout Project StatusT
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026263 VEGA Gene Model | MGI Sequence Detail 8074 C57BL/6J ±  kb
transcript OTTMUST00000064950 VEGA | MGI Sequence Detail 2046 Not Applicable 
polypeptide OTTMUSP00000032305 VEGA | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(28) UniProt(7)
Polymorphisms
RFLP(5) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR002070 Transcription factor, Brachyury
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000016001 brachyury protein
References
(Earliest) J:14909 Dobrovolskaia-Zavadskaia N, Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere (facteur) hereditaire "non-viable". C R Seances Soc Biol Fil. 1927;97:114-16
(Latest) J:214731 Pulina M, et al., Shape and position of the node and notochord along the bilateral plane of symmetry are regulated by cell-extracellular matrix interactions. Biol Open. 2014;3(7):583-90
All references(683)
Other
accession IDs
MGD-MRK-11865, MGD-MRK-11883, MGD-MRK-14695, MGD-MRK-2096, MGI:2152887, MGI:2152888

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory