About   Help   FAQ
T Gene Detail
Summary
  • Symbol
    T
  • Name
    brachyury, T-box transcription factor T
  • Synonyms
    Bra, T1, Tbxt
Location &
Maps
more
  • Sequence Map
    Chr17:8653255-8661328 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 4.92 cM
  • Mapping Data
    105 experiments
Strain
Comparison
more
  • SNPs within 2kb
    254 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98472
 protein coding gene Chr17:8653255-8661328 (+)
129S1/SvImJ ENSMUSG00200033192
 protein coding gene Chr17:4888423-4896491 (+)
A/J ENSMUSG00195023029
 protein coding gene Chr17:5096722-5104799 (+)
AKR/J ENSMUSG00220025549
 protein coding gene Chr17:5161897-5169975 (+)
BALB/cJ ENSMUSG00180021643
 protein coding gene Chr17:4742940-4751016 (+)
C3H/HeJ ENSMUSG00175031190
 protein coding gene Chr17:4887219-4895295 (+)
C57BL/6NJ ENSMUSG00215025589
 protein coding gene Chr17:4895579-4903652 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021061
 protein coding gene Chr17:8427938-8435930 (-)
CAST/EiJ ENSTCUG00005021916
 protein coding gene Chr17:5134656-5142633 (+)
CBA/J ENSMUSG00210034964
 protein coding gene Chr17:4554031-4562106 (+)
DBA/2J ENSMUSG00185022173
 protein coding gene Chr17:5646690-5654765 (+)
FVB/NJ ENSMUSG00205008409
 protein coding gene Chr17:4959821-4967897 (+)
JF1/MsJ ENSUMUG00000017002
 protein coding gene Chr17:5248331-5256499 (+)
LP/J ENSMUSG00230032165
 protein coding gene Chr17:7082207-7090286 (+)
NOD/ShiLtJ ENSMUSG00190031735
 protein coding gene Chr17:5092416-5100492 (+)
NZO/HlLtJ ENSMUSG00225029004
 protein coding gene Chr17:9002497-9010575 (+)
PWK/PhJ ENSLUMG00010018467
 protein coding gene Chr17:5061997-5070168 (+)
SPRET/EiJ ENSMSPG00010036574
 protein coding gene Chr17:9212526-9220503 (-)
WSB/EiJ ENSIUOG00005013589
 protein coding gene Chr17:4945915-4953991 (+)



Homology
more
  • Human Ortholog
    TBXT, T-box transcription factor T
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBXT, T-box transcription factor T
  • Synonyms
    SAVA, T, TFT
  • Links
    NCBI Gene ID: 6862
    UniProt: O15178

  • Chr Location
    6q27; chr6:166157656-166168815 (-)  GRCh38
  • MGI Vertebrate Homology
    T stringent orthology
    1 human;1 mouse;1 rat;2 zebrafish
  • HCOP
    vertebrate homology predictions: TBXT
  • Gene Tree
    T
Human Diseases
more
  • Diseases
    1 with human TBXT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    76 phenotypes from 29 alleles in 23 genetic backgrounds
    72 phenotypes from multigenic genotypes
    3 images
    506 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice die during embryonic development. Heterozygous mice have skeletal abnormalities. On specific genetic backgrounds, some alleles cause partial or complete sex-reversal of chromosomally XY mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2733
  • Tissues
    420
  • cDNA Data
    46
  • Literature Summary
    671
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20997 NCBI Gene Model | MGI Sequence Detail 8074 C57BL/6J ±  kb
    transcript NM_009309 RefSeq | MGI Sequence Detail 2046 ZRU/MplStud  
    polypeptide P20293 UniProt | EBI | MGI Sequence Detail 436 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 205
      Genomic 4
      cDNA 59
      Primer pair 46
      Other 96
      Antibodies 22

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11865, MGD-MRK-11883, MGD-MRK-14695, MGD-MRK-2096, MGI:2152887, MGI:2152888
    References
    more
    • Summaries
      All 1331
      Developmental Gene Expression 671
      Diseases 6
      Gene Ontology 26
      Phenotypes 506
    • Earliest
      J:14909 Dobrovolskaia-Zavadskaia N, Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere (facteur) hereditaire "non-viable". C R Seances Soc Biol Fil. 1927;97:114-16
    • Latest
      J:391449 Thibodeau J, et al., Loss of cystathionine-beta-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome. Biochem Pharmacol. 2026 Feb 13;247:117815
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory