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T Gene Detail
Summary
  • Symbol
    T
  • Name
    brachyury
  • Synonyms
    Bra, T1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98472
    NCBI Gene: 20997
Location & Maps
more
Homology
more
  • Human Ortholog
    T, T brachyury transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    T, T brachyury transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SAVA, TFT
  • Links
    NCBI Gene ID: 6862
    neXtProt AC: NX_O15178

  • Chr Location
    6q27; chr6:166157656-166168669 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human T associations

Human Disease Mouse Models
       Neural Tube Defects, Susceptibility To; NTD   OMIM: 182940
Sacral Agenesis with Vertebral Anomalies; SAVA   OMIM: 615709
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    85 phenotypes from 35 alleles in 22 genetic backgrounds
    57 phenotypes from multigenic genotypes
    3 images
    106 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    52
  • Chemically and radiation induced
    6
  • Chemically induced (ENU)
    6
  • Not Applicable
    1
  • Radiation induced
    18
  • Spontaneous
    15
  • Targeted
    4
  • Transgenic
    2
  • Genomic Mutations
    15 involving T
  • Incidental Mutations
Homozygous mice die during embryonice development. Heterozygous mice have skeletal abnormalities. On specific genetic backgrounds, some alleles cause partial or complete sex-reversal of chromosomally XY mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026263 VEGA Gene Model | MGI Sequence Detail 8074 C57BL/6J ±  kb
transcript OTTMUST00000064950 VEGA | MGI Sequence Detail 2046 Not Applicable  
polypeptide OTTMUSP00000032305 VEGA | MGI Sequence Detail 436 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    60 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016001 brachyury protein
  • InterPro Domains
    IPR008967 p53-like transcription factor, DNA-binding
    IPR002070 Transcription factor, Brachyury
    IPR001699 Transcription factor, T-box
    IPR018186 Transcription factor, T-box, conserved site
Molecular
Reagents
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  • All nucleic 111
    Genomic 4
    cDNA 48
    Primer pair 21
    Other 38

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11865, MGD-MRK-11883, MGD-MRK-14695, MGD-MRK-2096, MGI:2152887, MGI:2152888
References
more
  • Summaries
    All 708
    Developmental Gene Expression 477
    Diseases 2
    Gene Ontology 24
    Phenotypes 106
  • Earliest
    J:14909 Dobrovolskaia-Zavadskaia N, Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere (facteur) hereditaire "non-viable". C R Seances Soc Biol Fil. 1927;97:114-16
  • Latest
    J:226614 Costello I, et al., Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory