Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SRGAP2,SRGAP2B,SRGAP2C
  • Mouse genes Srgap2
  • Rat genes Srgap2
  • Zfish genes srgap2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Srgap2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	SRGAP2	IMP		Human	PMID:20810653
Molecular Function	GO:0005096	GTPase activator activity	SRGAP2	IDA		Human	PMID:21148482
Molecular Function	GO:0005096	GTPase activator activity	SRGAP2	IDA		Human	PMID:27373832
Molecular Function	GO:0005096	GTPase activator activity	Srgap2	IDA		Mouse	MGI:MGI:6867123|PMID:26439400
Molecular Function	GO:0005096	GTPase activator activity	Srgap2	IDA		Mouse	MGI:MGI:4366584|PMID:19737524
Molecular Function	GO:0042802	identical protein binding	SRGAP2	IPI	UniProtKB:O75044	Human	PMID:20810653
Molecular Function	GO:0042802	identical protein binding	SRGAP2	IPI	UniProtKB:O75044	Human	PMID:26365803
Molecular Function	GO:0005515	protein binding	SRGAP2	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	SRGAP2	IPI	UniProtKB:P48023	Human	PMID:16318909
Molecular Function	GO:0005515	protein binding	SRGAP2	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	SRGAP2	IPI	UniProtKB:P48023	Human	PMID:19807924
Molecular Function	GO:0005515	protein binding	SRGAP2	IPI	UniProtKB:O14744	Human	PMID:20810653
Molecular Function	GO:0005515	protein binding	SRGAP2	IPI	UniProtKB:O95466	Human	PMID:21148482
Molecular Function	GO:0005515	protein binding	SRGAP2	IPI	UniProtKB:P0DJJ0	Human	PMID:22559944
Molecular Function	GO:0005515	protein binding	SRGAP2	IPI	UniProtKB:Q9Y6N7	Human	PMID:26365803
Molecular Function	GO:0005515	protein binding	SRGAP2	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Srgap2	IPI	UniProtKB:Q05859	Mouse	PMID:8605874
Molecular Function	GO:0046982	protein heterodimerization activity	SRGAP2C	IPI	UniProtKB:O75044	Human	PMID:22559944
Molecular Function	GO:0042803	protein homodimerization activity	SRGAP2	IDA		Human	PMID:20810653
Molecular Function	GO:0042803	protein homodimerization activity	SRGAP2C	IPI	UniProtKB:P0DJJ0	Human	PMID:22559944
Molecular Function	GO:0042803	protein homodimerization activity	Srgap2	IDA		Mouse	MGI:MGI:4366584|PMID:19737524
Molecular Function	GO:0031267	small GTPase binding	SRGAP2	IDA		Human	PMID:20810653
Molecular Function	GO:0031267	small GTPase binding	SRGAP2	IDA		Human	PMID:21148482
Molecular Function	GO:0031267	small GTPase binding	Srgap2	IDA		Mouse	MGI:MGI:4366584|PMID:19737524
Cellular Component	GO:0005737	cytoplasm	Srgap2	IDA		Rat	PMID:17710530|RGD:8554217
Cellular Component	GO:0005737	cytoplasm	Srgap2	IDA		Rat	PMID:27748913|RGD:151356607
Cellular Component	GO:0005829	cytosol	Srgap2	IDA		Mouse	MGI:MGI:5426775|PMID:21148482
Cellular Component	GO:0043197	dendritic spine	Srgap2	IDA		Mouse	MGI:MGI:5829526|PMID:27373832
Cellular Component	GO:0044327	dendritic spine head	SRGAP2	IDA		Human	PMID:22559944
Cellular Component	GO:0030027	lamellipodium	SRGAP2	IDA		Human	PMID:20810653
Cellular Component	GO:0005743	mitochondrial inner membrane	Srgap2	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005634	nucleus	Srgap2	IDA		Rat	PMID:17710530|RGD:8554217
Cellular Component	GO:0005634	nucleus	Srgap2	IDA		Rat	PMID:27748913|RGD:151356607
Cellular Component	GO:0045335	phagocytic vesicle	Srgap2	IDA		Mouse	MGI:MGI:5426775|PMID:21148482
Cellular Component	GO:0005886	plasma membrane	SRGAP2	IDA		Human	PMID:21148482
Cellular Component	GO:0005886	plasma membrane	Srgap2	IDA		Mouse	MGI:MGI:4366584|PMID:19737524
Cellular Component	GO:0014069	postsynaptic density	Srgap2	IDA		Mouse	MGI:MGI:5427519|PMID:22559944
Cellular Component	GO:0045211	postsynaptic membrane	Srgap2	IDA		Mouse	MGI:MGI:5427519|PMID:22559944
Biological Process	GO:0051014	actin filament severing	SRGAP2	IDA		Human	PMID:21148482
Biological Process	GO:0021987	cerebral cortex development	SRGAP2C	IDA		Human	PMID:27373832
Biological Process	GO:0021987	cerebral cortex development	SRGAP2C	IDA		Human	PMID:34707291
Biological Process	GO:0060996	dendritic spine development	SRGAP2	IDA		Human	PMID:22559944
Biological Process	GO:0060996	dendritic spine development	Srgap2	IMP		Mouse	MGI:MGI:5427519|PMID:22559944
Biological Process	GO:1904861	excitatory synapse assembly	SRGAP2	IDA		Human	PMID:27373832
Biological Process	GO:1904861	excitatory synapse assembly	SRGAP2C	IDA		Human	PMID:27373832
Biological Process	GO:1904861	excitatory synapse assembly	SRGAP2C	IDA		Human	PMID:34707291
Biological Process	GO:1904861	excitatory synapse assembly	Srgap2	IMP		Mouse	MGI:MGI:5829526|PMID:27373832
Biological Process	GO:0021816	extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	SRGAP2C	IDA		Human	PMID:22559944
Biological Process	GO:0021816	extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	Srgap2	IMP		Mouse	MGI:MGI:4366584|PMID:19737524
Biological Process	GO:0046847	filopodium assembly	SRGAP2	IDA		Human	PMID:22559944
Biological Process	GO:0046847	filopodium assembly	Srgap2	IDA		Mouse	MGI:MGI:4366584|PMID:19737524
Biological Process	GO:1904862	inhibitory synapse assembly	SRGAP2	IDA		Human	PMID:27373832
Biological Process	GO:1904862	inhibitory synapse assembly	SRGAP2C	IDA		Human	PMID:27373832
Biological Process	GO:1904862	inhibitory synapse assembly	SRGAP2C	IDA		Human	PMID:34707291
Biological Process	GO:1904862	inhibitory synapse assembly	Srgap2	IMP		Mouse	MGI:MGI:5829526|PMID:27373832
Biological Process	GO:0003363	lamellipodium assembly involved in ameboidal cell migration	SRGAP2	IMP		Human	PMID:20810653
Biological Process	GO:0061000	negative regulation of dendritic spine development	SRGAP2C	IDA		Human	PMID:22559944
Biological Process	GO:0051490	negative regulation of filopodium assembly	SRGAP2C	IDA		Human	PMID:22559944
Biological Process	GO:2001223	negative regulation of neuron migration	SRGAP2	IDA		Human	PMID:22559944
Biological Process	GO:0048812	neuron projection morphogenesis	Srgap2	IMP		Mouse	MGI:MGI:4366584|PMID:19737524
Biological Process	GO:0072015	podocyte development	srgap2	IMP	ZFIN:ZDB-MRPHLNO-191210-1	Zfish	PMID:29242313
Biological Process	GO:0043547	positive regulation of GTPase activity	SRGAP2	IMP		Human	PMID:20810653
Biological Process	GO:0043547	positive regulation of GTPase activity	SRGAP2	IDA		Human	PMID:21148482
Biological Process	GO:0043547	positive regulation of GTPase activity	SRGAP2	IDA		Human	PMID:27373832
Biological Process	GO:0043547	positive regulation of GTPase activity	Srgap2	IDA		Mouse	MGI:MGI:4366584|PMID:19737524
Biological Process	GO:2001224	positive regulation of neuron migration	SRGAP2C	IDA		Human	PMID:22559944
Biological Process	GO:0030334	regulation of cell migration	Srgap2	IDA		Mouse	MGI:MGI:6867123|PMID:26439400
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	SRGAP2	IMP		Human	PMID:20810653

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern