Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SRD5A1
  • Mouse genes Srd5a1
  • Rat genes Srd5a1
  • Zfish genes srd5a1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Srd5a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	SRD5A1	IDA		Human	PMID:17986282
Molecular Function	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	Srd5a1	IMP		Mouse	PMID:15249131
Molecular Function	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	Srd5a1	IDA		Rat	PMID:7482629|RGD:2326071
Molecular Function	GO:0033218	amide binding	Srd5a1	IDA		Rat	PMID:9090798|RGD:4892036
Molecular Function	GO:0070402	NADPH binding	Srd5a1	IDA		Rat	PMID:11377984|RGD:4891997
Cellular Component	GO:0070852	cell body fiber	Srd5a1	IDA		Rat	PMID:15305365|RGD:4891939
Cellular Component	GO:0005737	cytoplasm	Srd5a1	IDA		Rat	PMID:15305365|RGD:4891939
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Srd5a1	IDA		Rat	PMID:20724274|RGD:4891503
Cellular Component	GO:0043209	myelin sheath	Srd5a1	IDA		Rat	PMID:9202401|RGD:4892033
Cellular Component	GO:0043025	neuronal cell body	Srd5a1	IDA		Rat	PMID:15305365|RGD:4891939
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Srd5a1	IDA		Rat	PMID:7553073|RGD:2326073
Biological Process	GO:0006702	androgen biosynthetic process	Srd5a1	IMP	MGI:MGI:1857454	Mouse	PMID:15249131
Biological Process	GO:0006702	androgen biosynthetic process	Srd5a1	IDA		Rat	PMID:12606426|RGD:4891962
Biological Process	GO:0006710	androgen catabolic process	Srd5a1	IDA		Rat	PMID:2339109|RGD:70289
Biological Process	GO:0008209	androgen metabolic process	Srd5a1	IDA		Rat	PMID:20954080|RGD:4891498
Biological Process	GO:0060348	bone development	Srd5a1	IEP		Rat	PMID:15012600|RGD:4891061
Biological Process	GO:0071320	cellular response to cAMP	Srd5a1	IEP		Rat	PMID:14997014|RGD:4891943
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Srd5a1	IEP		Rat	PMID:15004407|RGD:4891941
Biological Process	GO:0071872	cellular response to epinephrine stimulus	Srd5a1	IEP		Rat	PMID:14997014|RGD:4891943
Biological Process	GO:0071392	cellular response to estradiol stimulus	Srd5a1	IEP		Rat	PMID:15312799|RGD:4891936
Biological Process	GO:0071363	cellular response to growth factor stimulus	Srd5a1	IEP		Rat	PMID:15249139|RGD:4891940
Biological Process	GO:0032869	cellular response to insulin stimulus	Srd5a1	IEP		Rat	PMID:20810561|RGD:4891501
Biological Process	GO:0071407	cellular response to organic cyclic compound	Srd5a1	IEP		Rat	PMID:15936112|RGD:4891926
Biological Process	GO:0009267	cellular response to starvation	Srd5a1	IEP		Rat	PMID:9729333|RGD:1600064
Biological Process	GO:0071394	cellular response to testosterone stimulus	Srd5a1	IEP		Rat	PMID:15004407|RGD:4891941
Biological Process	GO:0021987	cerebral cortex development	Srd5a1	IEP		Rat	PMID:8770891|RGD:4892048
Biological Process	GO:0042747	circadian sleep/wake cycle, REM sleep	Srd5a1	IEP		Rat	PMID:12597996|RGD:4891963
Biological Process	GO:0016101	diterpenoid metabolic process	Srd5a1	IEP		Rat	PMID:14997014|RGD:4891943
Biological Process	GO:0030540	female genitalia development	Srd5a1	IEP		Rat	PMID:9142501|RGD:4892034
Biological Process	GO:0021766	hippocampus development	Srd5a1	IEP		Rat	PMID:8770891|RGD:4892048
Biological Process	GO:0021854	hypothalamus development	Srd5a1	IEP		Rat	PMID:15804399|RGD:4891928
Biological Process	GO:0021854	hypothalamus development	Srd5a1	IEP		Rat	PMID:8770891|RGD:4892048
Biological Process	GO:0001889	liver development	Srd5a1	IEP		Rat	PMID:8770891|RGD:4892048
Biological Process	GO:0030539	male genitalia development	Srd5a1	IEP		Rat	PMID:9142501|RGD:4892034
Biological Process	GO:0008584	male gonad development	Srd5a1	IEP		Rat	PMID:12606426|RGD:4891962
Biological Process	GO:0021983	pituitary gland development	Srd5a1	IEP		Rat	PMID:8770891|RGD:4892048
Biological Process	GO:0042448	progesterone metabolic process	Srd5a1	IDA		Rat	PMID:9202401|RGD:4892033
Biological Process	GO:0032355	response to estradiol	Srd5a1	IEP		Rat	PMID:9504773|RGD:4892024
Biological Process	GO:0043627	response to estrogen	Srd5a1	IEP		Rat	PMID:19793540|RGD:4891149
Biological Process	GO:0032354	response to follicle-stimulating hormone	Srd5a1	IEP		Rat	PMID:12630924|RGD:1600068
Biological Process	GO:0060992	response to fungicide	Srd5a1	IEP		Rat	PMID:19728174|RGD:4891525
Biological Process	GO:0060416	response to growth hormone	Srd5a1	IEP		Rat	PMID:10067850|RGD:4892008
Biological Process	GO:0014850	response to muscle activity	Srd5a1	IEP		Rat	PMID:20045012|RGD:4891513
Biological Process	GO:0014070	response to organic cyclic compound	Srd5a1	IEP		Rat	PMID:17940878|RGD:4891890
Biological Process	GO:0033574	response to testosterone	Srd5a1	IEP		Rat	PMID:16595696|RGD:4891918
Biological Process	GO:0009410	response to xenobiotic stimulus	Srd5a1	IMP		Rat	PMID:1314830|RGD:2302561
Biological Process	GO:0042428	serotonin metabolic process	Srd5a1	IEP		Rat	PMID:15936112|RGD:4891926
Biological Process	GO:0021510	spinal cord development	Srd5a1	IEP		Rat	PMID:8770891|RGD:4892048
Biological Process	GO:0006694	steroid biosynthetic process	Srd5a1	IDA		Rat	PMID:7482629|RGD:2326071
Biological Process	GO:0021794	thalamus development	Srd5a1	IEP		Rat	PMID:8770891|RGD:4892048
Biological Process	GO:0001655	urogenital system development	Srd5a1	IEP		Rat	PMID:8584033|RGD:4892046

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern