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Srd5a1
Gene Detail
 Symbol
Name
ID
Srd5a1
steroid 5 alpha-reductase 1
MGI:98400
Synonyms 0610031P22Rik, 4930435F02Rik, Srd5a-1
Feature Type protein coding gene
Genetic Map
Chromosome 13
35.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr13:69573449-69611442 bp, - strand
From VEGA annotation of GRCm38

  37994 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 3-oxo-5-alpha-steroid 4-dehydrogenase 2
Gene Tree: Srd5a1

Human
homologs
Human Homolog SRD5A1, steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
NCBI Gene ID 6715
neXtProt AC  NX_P18405
Human Synonyms  S5AR 1
Human Chr (Location)  5p15; chr5:6633367-6669562 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from APF )
 
Female mice homozygous for a targeted mutation exhibit parturiton defects and deliver small litters. Male homozygous mice appear healthy.
 
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process androgen biosynthetic process, androgen metabolic process, ...
Component cell body fiber, cytoplasm, ...
Function 3-oxo-5-alpha-steroid 4-dehydrogenase activity, amide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (122)    Tissues (104)    Images (11)
Theiler Stages: 22, 23, 25, 28
Assay TypeResults
RNA in situ 110
RT-PCR 12
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000035506 (Evidence)
Ensembl Gene ModelENSMUSG00000021594 (Evidence)
Entrez Gene78925 (Evidence)
DFCITC1577202, TC1596275, TC1611612
DoTSDT.110974745, DT.527223, DT.55163718, DT.91351928, DT.94247873, DT.94247903
NIA Mouse Gene IndexU034936
EC1.3.1.22
Consensus CDS ProjectCCDS26624.1
International Mouse Knockout Project StatusSrd5a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035506 VEGA Gene Model | MGI Sequence Detail 37994 C57BL/6J ±  kb
transcript OTTMUST00000090926 VEGA | MGI Sequence Detail 2644 Not Applicable 
polypeptide OTTMUSP00000050010 VEGA | MGI Sequence Detail 255 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(450 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016636 3-oxo-5-alpha-steroid 4-dehydrogenase
InterPro IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
Protein Ontology PR:000015607 3-oxo-5-alpha-steroid 4-dehydrogenase 1
References (Earliest) J:1969 Jenkins EP, et al., Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue. Genomics. 1991 Dec;11(4):1102-12
(Latest) J:205146 Praktiknjo SD, et al., Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programming in male mice. Endocrinology. 2013 Dec;154(12):4746-56
All references(52)
Other
accession IDs
MGD-MRK-14560, MGD-MRK-14561, MGI:1915624, MGI:1926175

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory