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Srd5a1 Gene Detail
Summary
  • Symbol
    Srd5a1
  • Name
    steroid 5 alpha-reductase 1
  • Synonyms
    0610031P22Rik, 4930435F02Rik, Srd5a-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98400
    NCBI Gene: 78925
  • Gene Overview
    MyGene.info: SRD5A1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:69573449-69611442 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 35.55 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    447 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98400
protein coding gene Chr13:69573449-69611907 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020733
protein coding gene Chr13:69848255-69888763 (-)
A/J MGP_AJ_G0020689
protein coding gene Chr13:67346981-67387338 (-)
AKR/J MGP_AKRJ_G0020664
protein coding gene Chr13:69573662-69609855 (-)
BALB/cJ MGP_BALBcJ_G0020686
protein coding gene Chr13:67883577-67920263 (-)
C3H/HeJ MGP_C3HHeJ_G0020481
protein coding gene Chr13:69236533-69276356 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021123
protein coding gene Chr13:72245391-72285768 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018691
protein coding gene Chr13:64317866-64354083 (-)
CAST/EiJ MGP_CASTEiJ_G0019998
protein coding gene Chr13:68230148-68269892 (-)
CBA/J MGP_CBAJ_G0020439
protein coding gene Chr13:75025676-75062716 (-)
DBA/2J MGP_DBA2J_G0020565
protein coding gene Chr13:67251365-67289752 (-)
FVB/NJ MGP_FVBNJ_G0020545
protein coding gene Chr13:66254636-66293283 (-)
LP/J MGP_LPJ_G0020637
protein coding gene Chr13:70135222-70171320 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020573
protein coding gene Chr13:73475084-73516453 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021162
protein coding gene Chr13:68846160-68884821 (-)
PWK/PhJ MGP_PWKPhJ_G0019752
protein coding gene Chr13:65949322-65986845 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019575
protein coding gene Chr13:65343889-65381007 (-)
WSB/EiJ MGP_WSBEiJ_G0020055
protein coding gene Chr13:69338394-69377126 (-)



Homology
more
  • Human Ortholog
    SRD5A1, steroid 5 alpha-reductase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRD5A1, steroid 5 alpha-reductase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    S5AR 1
  • Links
    NCBI Gene ID: 6715
    neXtProt AC: NX_P18405
    UniProt: P18405

  • Chr Location
    5p15.31; chr5:6633322-6669562 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    3
  • Genomic Mutations
    1 involving Srd5a1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Female mice homozygous for a targeted mutation exhibit parturiton defects and deliver small litters. Male homozygous mice appear healthy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021594 Ensembl Gene Model | MGI Sequence Detail 37994 C57BL/6J ±  kb
transcript ENSMUST00000091514 Ensembl | MGI Sequence Detail 2644 Not Applicable  
polypeptide ENSMUSP00000089097 Ensembl | MGI Sequence Detail 255 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • EC
  • InterPro Domains
    IPR016636 3-oxo-5-alpha-steroid 4-dehydrogenase
    IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
    IPR039357 3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase
Molecular
Reagents
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  • All nucleic 15
    Genomic 1
    cDNA 12
    Primer pair 1
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-14560, MGD-MRK-14561, MGI:1915624, MGI:1926175
References
more
  • Summaries
    All 59
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 23
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:245782 Opoku-Acheampong AB, et al., 5alpha-reductase 1 mRNA levels are positively correlated with TRAMP mouse prostate most severe lesion scores. PLoS One. 2017;12(5):e0175874

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory