Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMPD1
  • Mouse genes Smpd1
  • Rat genes Smpd1
  • Zfish genes smpd1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smpd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	SMPD1	IDA		Human	PMID:17303575
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	SMPD1	IDA		Human	PMID:18815062
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	SMPD1	IDA		Human	PMID:20807762
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	SMPD1	IDA		Human	PMID:8702487
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	Smpd1	IDA		Mouse	MGI:MGI:82648|PMID:8702487
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	Smpd1	IDA		Mouse	PMID:35705808
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	Smpd1	IDA		Mouse	PMID:16025116
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	Smpd1	IDA		Mouse	PMID:23046545
Molecular Function	GO:0005515	protein binding	SMPD1	IPI	UniProtKB:Q99523	Human	PMID:16787399
Molecular Function	GO:0005515	protein binding	SMPD1	IPI	UniProtKB:P55210	Human	PMID:21157428
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	SMPD1	IDA		Human	PMID:21098024
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	SMPD1	IDA		Human	PMID:22573858
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	SMPD1	IDA		Human	PMID:33163980
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	SMPD1	IDA		Human	PMID:9660788
Molecular Function	GO:0008270	zinc ion binding	SMPD1	IDA		Human	PMID:8702487
Molecular Function	GO:0008270	zinc ion binding	SMPD1	IDA		Human	PMID:9660788
Molecular Function	GO:0008270	zinc ion binding	Smpd1	IDA		Mouse	MGI:MGI:82648|PMID:8702487
Cellular Component	GO:0036019	endolysosome	SMPD1	IDA		Human	PMID:17303575
Cellular Component	GO:0005768	endosome	SMPD1	IDA		Human	PMID:20956541
Cellular Component	GO:0070062	extracellular exosome	SMPD1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	SMPD1	IDA		Human	PMID:33163980
Cellular Component	GO:0005615	extracellular space	SMPD1	IDA		Human	PMID:16787399
Cellular Component	GO:0005615	extracellular space	SMPD1	IDA		Human	PMID:17303575
Cellular Component	GO:0005615	extracellular space	SMPD1	IDA		Human	PMID:20530211
Cellular Component	GO:0005615	extracellular space	SMPD1	IDA		Human	PMID:20807762
Cellular Component	GO:0005615	extracellular space	SMPD1	IDA		Human	PMID:21098024
Cellular Component	GO:0005615	extracellular space	SMPD1	IDA		Human	PMID:22573858
Cellular Component	GO:0005615	extracellular space	SMPD1	IDA		Human	PMID:27659707
Cellular Component	GO:0005615	extracellular space	SMPD1	IDA		Human	PMID:8702487
Cellular Component	GO:0005615	extracellular space	SMPD1	IDA		Human	PMID:9660788
Cellular Component	GO:0005615	extracellular space	Smpd1	IDA		Mouse	MGI:MGI:82648|PMID:8702487
Cellular Component	GO:0005615	extracellular space	Smpd1	IDA		Mouse	PMID:35705808
Cellular Component	GO:0005615	extracellular space	Smpd1	IDA		Rat	PMID:17259995|RGD:1601345
Cellular Component	GO:0042599	lamellar body	Smpd1	IDA		Rat	PMID:12816958|RGD:1601349
Cellular Component	GO:0005764	lysosome	SMPD1	IDA		Human	PMID:33163980
Cellular Component	GO:0005764	lysosome	SMPD1	IDA		Human	PMID:16787399
Cellular Component	GO:0005764	lysosome	SMPD1	IDA		Human	PMID:18815062
Cellular Component	GO:0005764	lysosome	SMPD1	IDA		Human	PMID:20530211
Cellular Component	GO:0005764	lysosome	SMPD1	IDA		Human	PMID:20807762
Cellular Component	GO:0005764	lysosome	SMPD1	IDA		Human	PMID:20956541
Cellular Component	GO:0005764	lysosome	SMPD1	IDA		Human	PMID:21098024
Cellular Component	GO:0005764	lysosome	SMPD1	IDA		Human	PMID:27659707
Cellular Component	GO:0005764	lysosome	SMPD1	IDA		Human	PMID:9660788
Cellular Component	GO:0005886	plasma membrane	SMPD1	IDA		Human	PMID:20956541
Biological Process	GO:0071277	cellular response to calcium ion	SMPD1	IDA		Human	PMID:20530211
Biological Process	GO:0034644	cellular response to UV	SMPD1	IDA		Human	PMID:17303575
Biological Process	GO:0046513	ceramide biosynthetic process	SMPD1	IDA		Human	PMID:17303575
Biological Process	GO:0046513	ceramide biosynthetic process	SMPD1	IDA		Human	PMID:18815062
Biological Process	GO:0046513	ceramide biosynthetic process	SMPD1	IMP		Human	PMID:19279011
Biological Process	GO:0046513	ceramide biosynthetic process	SMPD1	IDA		Human	PMID:20807762
Biological Process	GO:0046513	ceramide biosynthetic process	SMPD1	IDA		Human	PMID:33163980
Biological Process	GO:0046513	ceramide biosynthetic process	SMPD1	IMP		Human	PMID:8706124
Biological Process	GO:0046513	ceramide biosynthetic process	Smpd1	IMP		Mouse	MGI:MGI:82530|PMID:8706124
Biological Process	GO:0046513	ceramide biosynthetic process	Smpd1	IDA		Mouse	PMID:35705808
Biological Process	GO:0046513	ceramide biosynthetic process	Smpd1	IMP		Rat	PMID:17261082|RGD:1601344
Biological Process	GO:0006672	ceramide metabolic process	Smpd1	IMP	MGI:MGI:2183206	Mouse	PMID:23046545
Biological Process	GO:0008203	cholesterol metabolic process	Smpd1	IMP		Mouse	PMID:22383528
Biological Process	GO:0043407	negative regulation of MAP kinase activity	SMPD1	IMP		Human	PMID:19279008
Biological Process	GO:0001778	plasma membrane repair	SMPD1	IDA		Human	PMID:20530211
Biological Process	GO:0001778	plasma membrane repair	Smpd1	IDA		Mouse	PMID:35705808
Biological Process	GO:0043065	positive regulation of apoptotic process	SMPD1	IMP		Human	PMID:8706124
Biological Process	GO:0043065	positive regulation of apoptotic process	Smpd1	IMP		Mouse	MGI:MGI:82530|PMID:8706124
Biological Process	GO:0043065	positive regulation of apoptotic process	Smpd1	IMP		Rat	PMID:12816958|RGD:1601349
Biological Process	GO:0045807	positive regulation of endocytosis	SMPD1	IDA		Human	PMID:20530211
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	SMPD1	IMP		Human	PMID:19279008
Biological Process	GO:0046598	positive regulation of viral entry into host cell	SMPD1	IDA		Human	PMID:33163980
Biological Process	GO:0042220	response to cocaine	Smpd1	IDA		Rat	PMID:14736491|RGD:1601348
Biological Process	GO:0070555	response to interleukin-1	SMPD1	IDA		Human	PMID:20807762
Biological Process	GO:0010212	response to ionizing radiation	SMPD1	IMP		Human	PMID:8706124
Biological Process	GO:0010212	response to ionizing radiation	Smpd1	IMP		Mouse	MGI:MGI:82530|PMID:8706124
Biological Process	GO:0034612	response to tumor necrosis factor	SMPD1	IDA		Human	PMID:20807762
Biological Process	GO:0034340	response to type I interferon	SMPD1	IDA		Human	PMID:20807762
Biological Process	GO:0009615	response to virus	SMPD1	IDA		Human	PMID:22573858
Biological Process	GO:0009410	response to xenobiotic stimulus	Smpd1	IEP		Rat	PMID:17259076|RGD:1601346
Biological Process	GO:0006685	sphingomyelin catabolic process	SMPD1	IDA		Human	PMID:18815062
Biological Process	GO:0006685	sphingomyelin catabolic process	SMPD1	IDA		Human	PMID:20807762
Biological Process	GO:0006685	sphingomyelin catabolic process	SMPD1	IDA		Human	PMID:22573858
Biological Process	GO:0006685	sphingomyelin catabolic process	Smpd1	IMP		Mouse	PMID:23973266
Biological Process	GO:0023021	termination of signal transduction	SMPD1	IMP		Human	PMID:19279008
Biological Process	GO:0046718	viral entry into host cell	SMPD1	IDA		Human	PMID:33163980
Biological Process	GO:0046718	viral entry into host cell	SMPD1	IDA		Human	PMID:22573858
Biological Process	GO:0042060	wound healing	SMPD1	IDA		Human	PMID:20530211

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern