Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLPI
  • Mouse genes Slpi
  • Rat genes Slpi,Slpil2,Slpil3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slpi

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	SLPI	IDA		Human	PMID:2467900
Molecular Function	GO:0004866	endopeptidase inhibitor activity	SLPI	IDA		Human	PMID:12526812
Molecular Function	GO:0004866	endopeptidase inhibitor activity	Slpi	IDA		Mouse	MGI:MGI:6275118|PMID:12526812
Molecular Function	GO:0019899	enzyme binding	SLPI	IPI	UniProtKB:O15162	Human	PMID:19333378
Molecular Function	GO:0003729	mRNA binding	SLPI	IDA		Human	PMID:2467900
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:P28799	Human	PMID:12526812
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q9NRQ2	Human	PMID:19333378
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q8IZU0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:O43561-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:P41271-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q12805	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q13064	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q8IZU0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q8WWB5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q96Q77	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q96QK8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q9BXU9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLPI	IPI	UniProtKB:Q9UMX0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Slpi	IPI	UniProtKB:P28798	Mouse	MGI:MGI:6275118|PMID:12526812
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SLPI	IDA		Human	PMID:3462719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SLPI	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SLPI	HDA		Human	PMID:28675934
Cellular Component	GO:0070062	extracellular exosome	SLPI	HDA		Human	PMID:19199708
Cellular Component	GO:0005615	extracellular space	SLPI	IDA		Human	PMID:18714013
Cellular Component	GO:0005615	extracellular space	SLPI	IDA		Human	PMID:3462719
Cellular Component	GO:0005615	extracellular space	Slpi	IDA		Mouse	MGI:MGI:3777210|PMID:18322212
Cellular Component	GO:0005794	Golgi apparatus	SLPI	IDA		Human	GO_REF:0000052
Biological Process	GO:0019731	antibacterial humoral response	SLPI	IDA		Human	PMID:18714013
Biological Process	GO:0019731	antibacterial humoral response	Slpi	IMP		Mouse	MGI:MGI:3777210|PMID:18322212
Biological Process	GO:0006955	immune response	Slpi	IMP		Mouse	MGI:MGI:2651774|PMID:12615907
Biological Process	GO:0045087	innate immune response	Slpi	IMP		Mouse	MGI:MGI:3777210|PMID:18322212
Biological Process	GO:0035821	modulation of process of another organism	SLPI	IDA		Human	PMID:2467900
Biological Process	GO:0050728	negative regulation of inflammatory response	Slpi	IDA		Rat	PMID:10449524|RGD:634208
Biological Process	GO:0032091	negative regulation of protein binding	SLPI	IDA		Human	PMID:19333378
Biological Process	GO:0045071	negative regulation of viral genome replication	SLPI	IDA		Human	PMID:19333378
Biological Process	GO:0032496	response to lipopolysaccharide	Slpi	IMP		Mouse	MGI:MGI:2651774|PMID:12615907

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern