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Slpi Gene Detail
Summary
  • Symbol
    Slpi
  • Name
    secretory leukocyte peptidase inhibitor
  • Feature Type
    protein coding gene
  • IDs
    MGI:109297
    NCBI Gene: 20568
  • Gene Overview
    MyGene.info: SLPI
Location & Maps
more
  • Sequence Map
    Chr2:164354070-164389095 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35026 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 85.16 cM, cytoband H
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLPI, secretory leukocyte peptidase inhibitor
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SLPI, secretory leukocyte peptidase inhibitor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4
  • Links
    NCBI Gene ID: 6590
    neXtProt AC: NX_P03973

  • Chr Location
    20q13.12; chr20:45252239-45254564 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Incidental Mutations
Homozygous null mice been independently reported to exhibit increased susceptibility to LPS-induced endotoxin shock with elevated production of IL-6, impaired cutaneous wound healing with increased inflammation and elastase activity, and high susceptibility to pulmonary mycobacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001167 VEGA Gene Model | MGI Sequence Detail 35026 C57BL/6J ±  kb
transcript OTTMUST00000002263 VEGA | MGI Sequence Detail 876 Not Applicable  
polypeptide OTTMUSP00000001108 VEGA | MGI Sequence Detail 131 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    330 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 27
    Genomic 1
    cDNA 25
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-38342
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:38212 Jin FY, et al., Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide. Cell. 1997 Feb 7;88(3):417-26
  • Latest
    J:220133 McCartney-Francis N, et al., Aberrant host defense against Leishmania major in the absence of SLPI. J Leukoc Biol. 2014 Nov;96(5):917-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory