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Slpi
Gene Detail
 Symbol
Name
ID
Slpi
secretory leukocyte peptidase inhibitor
MGI:109297
Feature Type protein coding gene
Genetic Map
Chromosome 2
85.16 cM, cytoband H
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:164354070-164389095 bp, - strand
From VEGA annotation of GRCm38

  35026 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2305  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: four-disulfide core domain protein, WAP type
Gene Tree: Slpi

Human
homologs
Human Homolog SLPI, secretory leukocyte peptidase inhibitor
NCBI Gene ID 6590
neXtProt AC  NX_P03973
Human Synonyms  ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4
Human Chr (Location)  20q12; chr20:45252239-45254564 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mice been independently reported to exhibit increased susceptibility to LPS-induced endotoxin shock with elevated production of IL-6, impaired cutaneous wound healing with increased inflammation and elastase activity, and high susceptibility to pulmonary mycobacterial infection.
 
Interactions
Slpi interacts with 17 markers (Mir154, Mir188, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process negative regulation of peptidase activity, negative regulation of protein binding, ...
Component extracellular matrix, extracellular region, ...
Function enzyme binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (22)    Tissues (3)    Images (21)
Theiler Stages: 11, 23
Assay TypeResults
RNA in situ 20
RT-PCR 2
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001167 (Evidence)
Ensembl Gene ModelENSMUSG00000017002 (Evidence)
Entrez Gene20568 (Evidence)
UniGene371583
DFCITC1580162
DoTSDT.534109
NIA Mouse Gene IndexU023633
Consensus CDS ProjectCCDS17033.1
International Mouse Knockout Project StatusSlpi
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001167 VEGA Gene Model | MGI Sequence Detail 35026 C57BL/6J ±  kb
transcript OTTMUST00000002263 VEGA | MGI Sequence Detail 876 Not Applicable 
polypeptide OTTMUSP00000001108 VEGA | MGI Sequence Detail 131 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(333 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008197 Whey acidic protein-type 4-disulphide core
Protein Ontology PR:000015248 antileukoproteinase
References (Earliest) J:38212 Jin FY, et al., Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide. Cell. 1997 Feb 7;88(3):417-26
(Latest) J:208183 Jan Treda C, et al., Secretory leukocyte protease inhibitor modulates urethane-induced lung carcinogenesis. Carcinogenesis. 2014 Apr;35(4):896-904
All references(44)
Other
accession IDs
MGD-MRK-38342

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory