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Slpi Gene Detail
Summary
  • Symbol
    Slpi
  • Name
    secretory leukocyte peptidase inhibitor
  • Feature Type
    protein coding gene
  • IDs
    MGI:109297
    NCBI Gene: 20568
  • Gene Overview
    MyGene.info: SLPI
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164354070-164356507 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 85.16 cM, cytoband H
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109297
protein coding gene Chr2:164354070-164389095 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026848
protein coding gene Chr2:169783327-169822264 (-)
A/J MGP_AJ_G0026814
protein coding gene Chr2:162877824-162916395 (-)
AKR/J MGP_AKRJ_G0026785
protein coding gene Chr2:167721979-167758856 (-)
BALB/cJ MGP_BALBcJ_G0026823
protein coding gene Chr2:163240472-163278220 (-)
C3H/HeJ MGP_C3HHeJ_G0026565
protein coding gene Chr2:168076651-168112606 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027271
protein coding gene Chr2:174702597-174741818 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024641
protein coding gene Chr2:156291262-156325906 (-)
CAST/EiJ MGP_CASTEiJ_G0026025
protein coding gene Chr2:168492232-168531553 (-)
CBA/J MGP_CBAJ_G0026542
protein coding gene Chr2:181038483-181078758 (-)
DBA/2J MGP_DBA2J_G0026680
protein coding gene Chr2:162052772-162088614 (-)
FVB/NJ MGP_FVBNJ_G0026646
protein coding gene Chr2:160459696-160499932 (-)
LP/J MGP_LPJ_G0026783
protein coding gene Chr2:169869741-169912140 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026666
protein coding gene Chr2:184643153-184683161 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027327
protein coding gene Chr2:167623677-167660227 (-)
PWK/PhJ MGP_PWKPhJ_G0025760
protein coding gene Chr2:161626123-161663259 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025561
protein coding gene Chr2:166490565-166532620 (-)
WSB/EiJ MGP_WSBEiJ_G0026096
protein coding gene Chr2:168476709-168516632 (-)



Homology
more
  • Human Ortholog
    SLPI, secretory leukocyte peptidase inhibitor
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SLPI, secretory leukocyte peptidase inhibitor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4
  • Links
    NCBI Gene ID: 6590
    neXtProt AC: NX_P03973
    UniProt: P03973

  • Chr Location
    20q13.12; chr20:45252239-45254564 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice been independently reported to exhibit increased susceptibility to LPS-induced endotoxin shock with elevated production of IL-6, impaired cutaneous wound healing with increased inflammation and elastase activity, and high susceptibility to pulmonary mycobacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20568 NCBI Gene Model | MGI Sequence Detail 2438 C57BL/6J ±  kb
transcript NM_011414 RefSeq | MGI Sequence Detail 894 Not Specified  
polypeptide P97430 UniProt | EBI | MGI Sequence Detail 131 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 1
    cDNA 26
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38342
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:38212 Jin FY, et al., Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide. Cell. 1997 Feb 7;88(3):417-26
  • Latest
    J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory