Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SKI
  • Mouse genes Ski
  • Rat genes Ski
  • Zfish genes skia,skib
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ski

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Ski	IGI	MGI:MGI:109339	Mouse	PMID:19008232
Molecular Function	GO:0003682	chromatin binding	Ski	IGI	MGI:MGI:102780	Mouse	PMID:19008232
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SKI	IPI	UniProtKB:P10071	Human	PMID:12435627
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	SKI	IDA		Human	PMID:17469184
Molecular Function	GO:0046811	histone deacetylase inhibitor activity	Ski	IGI	MGI:MGI:97275	Mouse	PMID:17352741
Molecular Function	GO:0042802	identical protein binding	SKI	IPI	UniProtKB:P12755	Human	PMID:8514802
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:O75376	Human	PMID:10049357
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q60974	Human	PMID:10049357
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q96ST3	Human	PMID:10049357
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q13485	Human	PMID:12419246
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:P10070	Human	PMID:12435627
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q9QUI1	Human	PMID:12646588
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:O75376	Human	PMID:14525983
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:P84022	Human	PMID:14525983
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q13485	Human	PMID:14525983
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q96ST3	Human	PMID:14525983
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q13485	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q15796	Human	PMID:18729074
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:P97480	Human	PMID:19008232
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q62231	Human	PMID:19008232
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:O75376	Human	PMID:19032343
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:P84022	Human	PMID:19032343
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q13485	Human	PMID:19032343
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q15796	Human	PMID:19032343
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:P84022	Human	PMID:19049980
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q9HAZ2	Human	PMID:19049980
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q8VI24	Human	PMID:22334647
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:P84022	Human	PMID:22442258
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q15796	Human	PMID:22442258
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q6ZSG1	Human	PMID:23610558
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q13485	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q13485	Human	PMID:26977879
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q15796	Human	PMID:26977879
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:P12757-1	Human	PMID:8514802
Molecular Function	GO:0005515	protein binding	SKI	IPI	UniProtKB:Q13573	Human	PMID:9569025
Molecular Function	GO:0005515	protein binding	Ski	IPI	UniProtKB:Q8VI24	Mouse	MGI:MGI:5314844|PMID:22334647
Molecular Function	GO:0005515	protein binding	Ski	IPI	UniProtKB:P97471	Mouse	MGI:MGI:6098842|PMID:29072299
Molecular Function	GO:0005515	protein binding	Ski	IPI	PR:Q61602	Mouse	PMID:12435627
Molecular Function	GO:0019904	protein domain specific binding	SKI	IPI	UniProtKB:P51608	Human	PMID:11441023
Molecular Function	GO:0019901	protein kinase binding	SKI	IPI	UniProtKB:Q9H2X6	Human	PMID:12874272
Molecular Function	GO:0046332	SMAD binding	SKI	IPI	UniProtKB:Q15796	Human	PMID:15107821
Molecular Function	GO:0046332	SMAD binding	SKI	IPI	UniProtKB:P84022	Human	PMID:17469184
Molecular Function	GO:0046332	SMAD binding	SKI	IPI	UniProtKB:Q13485	Human	PMID:17469184
Molecular Function	GO:0031625	ubiquitin protein ligase binding	SKI	IPI	UniProtKB:Q99ML9	Human	PMID:17510063
Molecular Function	GO:0008270	zinc ion binding	SKI	IDA		Human	PMID:12419246
Cellular Component	GO:0005813	centrosome	SKI	IDA		Human	PMID:21600873
Cellular Component	GO:0005737	cytoplasm	Ski	IDA		Mouse	PMID:12435627
Cellular Component	GO:0016604	nuclear body	SKI	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	SKI	IDA		Human	PMID:12874272
Cellular Component	GO:0005654	nucleoplasm	SKI	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SKI	IDA		Human	PMID:17054724
Cellular Component	GO:0005634	nucleus	SKI	IDA		Human	PMID:17510063
Cellular Component	GO:0005634	nucleus	Ski	IDA		Mouse	PMID:17352741
Cellular Component	GO:0005634	nucleus	Ski	IDA		Mouse	PMID:12435627
Cellular Component	GO:0005634	nucleus	Ski	IDA		Mouse	PMID:7823166
Cellular Component	GO:0005634	nucleus	skib	IDA		Zfish	PMID:10906458
Cellular Component	GO:0005634	nucleus	skia	IDA		Zfish	PMID:10906458
Cellular Component	GO:0016605	PML body	SKI	IDA		Human	PMID:11430826
Cellular Component	GO:0032991	protein-containing complex	SKI	IDA		Human	PMID:23610558
Cellular Component	GO:0005667	transcription regulator complex	Ski	IPI	PR:Q62231	Mouse	PMID:19008232
Cellular Component	GO:0005667	transcription regulator complex	Ski	IPI	UniProtKB:P97480	Mouse	PMID:19008232
Cellular Component	GO:0017053	transcription repressor complex	Ski	IDA		Mouse	PMID:12435627
Biological Process	GO:0009948	anterior/posterior axis specification	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:11731796
Biological Process	GO:0060349	bone morphogenesis	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:9284043
Biological Process	GO:0043010	camera-type eye development	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:11731796
Biological Process	GO:0048593	camera-type eye morphogenesis	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:17003410
Biological Process	GO:0061337	cardiac conduction	skia	IGI	ZFIN:ZDB-MRPHLNO-130823-4,ZFIN:ZDB-MRPHLNO-130823-5	Zfish	PMID:23768516
Biological Process	GO:0060038	cardiac muscle cell proliferation	Ski	IEP		Rat	PMID:2447874|RGD:151665807
Biological Process	GO:0051216	cartilage development	skib	IMP	ZFIN:ZDB-MRPHLNO-090604-3	Zfish	PMID:23023332
Biological Process	GO:0051216	cartilage development	skia	IMP	ZFIN:ZDB-MRPHLNO-090604-1	Zfish	PMID:23023332
Biological Process	GO:0009953	dorsal/ventral pattern formation	skib	IMP	ZFIN:ZDB-MRPHLNO-090604-4	Zfish	PMID:11477695
Biological Process	GO:0009953	dorsal/ventral pattern formation	skib	IMP	ZFIN:ZDB-MRPHLNO-090604-3	Zfish	PMID:11477695
Biological Process	GO:0009953	dorsal/ventral pattern formation	skib	IDA		Zfish	PMID:10906458
Biological Process	GO:0009953	dorsal/ventral pattern formation	skia	IMP	ZFIN:ZDB-MRPHLNO-090604-1	Zfish	PMID:11477695
Biological Process	GO:0009953	dorsal/ventral pattern formation	skia	IMP	ZFIN:ZDB-MRPHLNO-090604-2	Zfish	PMID:11477695
Biological Process	GO:0009953	dorsal/ventral pattern formation	skia	IDA		Zfish	PMID:10906458
Biological Process	GO:0030326	embryonic limb morphogenesis	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:12435627
Biological Process	GO:0060325	face morphogenesis	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:11731796
Biological Process	GO:0060325	face morphogenesis	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:9284043
Biological Process	GO:0048144	fibroblast proliferation	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:11781823
Biological Process	GO:0001947	heart looping	skib	IMP	ZFIN:ZDB-MRPHLNO-090604-3	Zfish	PMID:23023332
Biological Process	GO:0001947	heart looping	skia	IMP	ZFIN:ZDB-MRPHLNO-090604-1	Zfish	PMID:23023332
Biological Process	GO:0002089	lens morphogenesis in camera-type eye	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:17003410
Biological Process	GO:0022011	myelination in peripheral nervous system	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:15312649
Biological Process	GO:0014902	myotube differentiation	SKI	IDA		Human	PMID:19008232
Biological Process	GO:0014902	myotube differentiation	Ski	IGI	MGI:MGI:102780	Mouse	PMID:19008232
Biological Process	GO:0014902	myotube differentiation	Ski	IDA		Mouse	PMID:17352741
Biological Process	GO:0014902	myotube differentiation	Ski	IGI	MGI:MGI:109339	Mouse	PMID:19008232
Biological Process	GO:0032926	negative regulation of activin receptor signaling pathway	SKI	IDA		Human	PMID:14699069
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	SKI	IDA		Human	PMID:14699069
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	SKI	IMP		Human	PMID:17054724
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Ski	IGI	MGI:MGI:88177	Mouse	PMID:21937600
Biological Process	GO:0008285	negative regulation of cell population proliferation	SKI	IDA		Human	PMID:11430826
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:11781823
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	SKI	IDA		Human	PMID:14699069
Biological Process	GO:0010626	negative regulation of Schwann cell proliferation	SKI	IGI	UniProtKB:P01137	Human	PMID:15312649
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SKI	IMP		Human	PMID:12435627
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SKI	IDA		Human	PMID:17469184
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Ski	IGI	MGI:MGI:97275	Mouse	PMID:7659522
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SKI	IGI	UniProtKB:P01137	Human	PMID:15312649
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SKI	IMP		Human	PMID:17054724
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SKI	IDA		Human	PMID:17469184
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SKI	IMP		Human	PMID:19049980
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Ski	IGI	MGI:MGI:1201674	Mouse	PMID:21937600
Biological Process	GO:0001843	neural tube closure	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:9284043
Biological Process	GO:0043585	nose morphogenesis	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:11731796
Biological Process	GO:0021772	olfactory bulb development	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:11731796
Biological Process	GO:0043388	positive regulation of DNA binding	SKI	IDA		Human	PMID:15107821
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ski	IDA		Mouse	PMID:17352741
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ski	IDA		Mouse	PMID:7659522
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ski	IGI	MGI:MGI:109339	Mouse	PMID:19008232
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ski	IGI	MGI:MGI:102780	Mouse	PMID:19008232
Biological Process	GO:0060041	retina development in camera-type eye	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:17003410
Biological Process	GO:0060021	roof of mouth development	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:11731796
Biological Process	GO:0048741	skeletal muscle fiber development	Ski	IMP	MGI:MGI:2177555	Mouse	PMID:9284043
Biological Process	GO:0060395	SMAD protein signal transduction	SKI	IDA		Human	PMID:12874272
Biological Process	GO:0035019	somatic stem cell population maintenance	Ski	IDA		Mouse	PMID:19379700

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern