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Ski
Gene Detail
Symbol

Name
ID
Ski
ski sarcoma viral oncogene homolog (avian)
MGI:98310
Synonyms
2310012I02Rik, 2610001A11Rik, MGC:8300
Feature Type
protein coding gene
Genetic Map
Chromosome 4
86.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:155154075-155222592 bp, - strand
From VEGA annotation of GRCm38

  68518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31124  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SKI
Protein SuperFamily: ski transforming protein
Gene Tree: Ski

Human
homologs
SKI, SKI proto-oncogene
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6497
neXtProt AC: NX_P12755

Human Synonyms: SGS, SKV

Human Chr (Location): 1p36.33; chr1:2228695-2310213 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SKI

Mutations,
alleles, and
phenotypes
All mutations/alleles(63) : Gene trapped(60) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos die during late gestation and exhibit neural tube defects, craniofacial anomalies, and reduced skeletal muscle mass. Haploinsufficient mice have an increased susceptibility to tumorigenesis.
 
Interactions
Ski interacts with 388 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process anterior/posterior axis specification, bone morphogenesis, ...
Component centrosome, cytoplasm, ...
Function chromatin binding, histone deacetylase inhibitor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
Western blot 1
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ski ; ZFIN skia, skib    NEW 
Molecular
reagents
All nucleic(27) Genomic(3) cDNA(23) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000010598 (Evidence)
Ensembl Gene Model ENSMUSG00000029050 (Evidence)
Entrez Gene 20481 (Evidence)
DFCI TC1574831, TC1598427, TC1603470, TC1605727
DoTS DT.103562247, DT.110802223, DT.492016, DT.94408521, DT.97408059
NIA Mouse Gene Index U025867
Consensus CDS Project CCDS19024.1
International Mouse Phenotyping Consortium Status Ski
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010598 VEGA Gene Model | MGI Sequence Detail 68518 C57BL/6J ±  kb
transcript OTTMUST00000024745 VEGA | MGI Sequence Detail 5522 Not Applicable 
polypeptide OTTMUSP00000011357 VEGA | MGI Sequence Detail 727 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(574 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014890 c-SKI SMAD4-binding domain
InterPro IPR009061 DNA binding domain, putative
InterPro IPR010919 SAND domain-like
InterPro IPR023216 Transcription regulator SKI/SnoN
InterPro IPR003380 Transforming protein Ski
Protein Ontology PR:000003214 ski oncogene
References
(Earliest) J:9932 Nomura N, et al., Isolation of human cDNA clones of ski and the ski-related gene, sno. Nucleic Acids Res. 1989 Jul 25;17(14):5489-500
(Latest) J:198828 Kelly CE, et al., Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 2013;11(4):e1001538
All references(69)
Other
accession IDs
MGD-MRK-14428, MGI:1915543, MGI:1916864, MGI:2136877, MGI:2140114, MGI:2140167

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory