Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SHARPIN
  • Mouse genes Sharpin
  • Rat genes Sharpin
  • Zfish genes sharpin
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sharpin

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Sharpin	IPI	RGD:631353	Rat	PMID:11178875|RGD:633925
Molecular Function	GO:0042802	identical protein binding	Sharpin	IPI	UniProtKB:Q9EQL9	Rat	PMID:11178875|RGD:633925
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	SHARPIN	IDA		Human	PMID:21455173
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	SHARPIN	IDA		Human	PMID:21455181
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q96EP0	Human	PMID:21455173
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q96EP0	Human	PMID:21455180
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q9BYM8	Human	PMID:21455180
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q9Y6K9	Human	PMID:21455180
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q96EP0	Human	PMID:21455181
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q9BYM8	Human	PMID:21455181
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q9Y6K9	Human	PMID:21709223
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:P08648	Human	PMID:21947080
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:P17301	Human	PMID:21947080
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q96EP0	Human	PMID:22158122
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q96EP0	Human	PMID:23032186
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q9BYM8	Human	PMID:23032186
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q9Y6K9	Human	PMID:23032186
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q96EP0	Human	PMID:23104095
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q96EP0	Human	PMID:24141947
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q9UDY8	Human	PMID:27070702
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q96EP0	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q96EP0	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q9BYM8	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	SHARPIN	IPI	UniProtKB:Q9Y6K9	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	Sharpin	IPI	UniProtKB:Q924T7	Mouse	MGI:MGI:5516129|PMID:23942237
Molecular Function	GO:0005515	protein binding	Sharpin	IPI	UniProtKB:Q924T7	Mouse	MGI:MGI:4947438|PMID:21455180
Molecular Function	GO:0005515	protein binding	Sharpin	IPI	UniProtKB:O08575|UniProtKB:P97767	Mouse	MGI:MGI:5437425|PMID:20956555
Molecular Function	GO:0005515	protein binding	Sharpin	IPI	UniProtKB:Q924T7	Mouse	MGI:MGI:4946301|PMID:21455181
Molecular Function	GO:0005515	protein binding	Sharpin	IPI	UniProtKB:Q9WV48	Rat	PMID:11178875|RGD:633925
Molecular Function	GO:0044877	protein-containing complex binding	Sharpin	IPI	RGD:621011|RGD:68424|RGD:621667	Rat	PMID:11178875|RGD:633925
Cellular Component	GO:0005829	cytosol	SHARPIN	IDA		Human	PMID:20179993
Cellular Component	GO:0030425	dendrite	Sharpin	IDA		Rat	PMID:11178875|RGD:633925
Cellular Component	GO:0071797	LUBAC complex	SHARPIN	IPI		Human	PMID:21455180
Cellular Component	GO:0071797	LUBAC complex	SHARPIN	IDA		Human	PMID:21455173
Cellular Component	GO:0071797	LUBAC complex	SHARPIN	IDA		Human	PMID:21455180
Cellular Component	GO:0071797	LUBAC complex	SHARPIN	IDA		Human	PMID:21455181
Cellular Component	GO:0071797	LUBAC complex	SHARPIN	IDA		Human	PMID:24726323
Cellular Component	GO:0071797	LUBAC complex	SHARPIN	IDA		Human	PMID:27523608
Cellular Component	GO:0071797	LUBAC complex	SHARPIN	IDA		Human	PMID:28481331
Cellular Component	GO:0014069	postsynaptic density	Sharpin	IDA		Rat	PMID:11178875|RGD:633925
Biological Process	GO:0030262	apoptotic nuclear changes	Sharpin	IMP	MGI:MGI:1856699	Mouse	PMID:7792947
Biological Process	GO:0007420	brain development	Sharpin	IEP		Rat	PMID:11178875|RGD:633925
Biological Process	GO:0042742	defense response to bacterium	SHARPIN	IDA		Human	PMID:28481331
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	sharpin	IMP	ZFIN:ZDB-MRPHLNO-101223-1	Zfish	PMID:20956555
Biological Process	GO:0008544	epidermis development	Sharpin	IMP	MGI:MGI:1856699	Mouse	PMID:7792947
Biological Process	GO:0048592	eye morphogenesis	sharpin	IMP	ZFIN:ZDB-MRPHLNO-101223-1	Zfish	PMID:20956555
Biological Process	GO:0031424	keratinization	Sharpin	IMP	MGI:MGI:1856699	Mouse	PMID:7792947
Biological Process	GO:0007005	mitochondrion organization	Sharpin	IMP	MGI:MGI:1856699	Mouse	PMID:7792947
Biological Process	GO:0050728	negative regulation of inflammatory response	Sharpin	IMP		Mouse	MGI:MGI:4947438|PMID:21455180
Biological Process	GO:0050728	negative regulation of inflammatory response	Sharpin	IMP		Mouse	MGI:MGI:4947439|PMID:21455173
Biological Process	GO:0071600	otic vesicle morphogenesis	sharpin	IMP	ZFIN:ZDB-MRPHLNO-101223-1	Zfish	PMID:20956555
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	SHARPIN	IDA		Human	PMID:21455173
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Sharpin	IMP		Mouse	MGI:MGI:4947438|PMID:21455180
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Sharpin	IMP		Mouse	MGI:MGI:4947439|PMID:21455173
Biological Process	GO:0097039	protein linear polyubiquitination	SHARPIN	IDA		Human	PMID:21455173
Biological Process	GO:0097039	protein linear polyubiquitination	SHARPIN	IDA		Human	PMID:21455180
Biological Process	GO:0097039	protein linear polyubiquitination	SHARPIN	IDA		Human	PMID:21455181
Biological Process	GO:0097039	protein linear polyubiquitination	SHARPIN	IDA		Human	PMID:29694895
Biological Process	GO:2000348	regulation of CD40 signaling pathway	SHARPIN	IDA		Human	PMID:21455173
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	SHARPIN	IDA		Human	PMID:21455173
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Sharpin	IMP		Mouse	MGI:MGI:4947438|PMID:21455180
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Sharpin	IMP		Mouse	MGI:MGI:4947439|PMID:21455173

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern