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Sharpin
Gene Detail
 Symbol
Name
ID
Sharpin
SHANK-associated RH domain interacting protein
MGI:1913331
Synonyms 0610041B22Rik, cpdm, SIPL1
Feature Type protein coding gene
Genetic Map
Chromosome 15
35.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:76347040-76351111 bp, - strand
From VEGA annotation of GRCm38

  4072 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11918  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Sharpin

Human
homologs
Human Homolog SHARPIN, SHANK-associated RH domain interactor
NCBI Gene ID 81858
neXtProt AC  NX_Q9H0F6
Human Synonyms  SIPL1
Human Chr (Location)  8q24.3; chr8:144098633-144104237 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(2) Gene trapped(2) Spontaneous(2)
 
Mutations in this gene produces chronic skin lesions.
 
Human Diseases Modeled Using Mouse Sharpin (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process apoptotic nuclear changes, epidermis development, ...
Component cell junction, cytoplasm, ...
Function identical protein binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(65) cDNA(65)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023724 (Evidence)
Ensembl Gene ModelENSMUSG00000022552 (Evidence)
Entrez Gene106025 (Evidence)
UniGene41463
DFCITC1575016, TC1588153, TC1603286
DoTSDT.101357524, DT.55221338, DT.91411059, DT.94259358, DT.97361201
NIA Mouse Gene IndexU036341
Consensus CDS ProjectCCDS37121.1
International Mouse Knockout Project StatusSharpin
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023724 VEGA Gene Model | MGI Sequence Detail 4072 C57BL/6J ±  kb
transcript OTTMUST00000057935 VEGA | MGI Sequence Detail 1734 Not Applicable 
polypeptide OTTMUSP00000028019 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(5) UniProt(3)
Polymorphisms SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026168 SHARPIN
InterPro IPR001876 Zinc finger, RanBP2-type
Protein Ontology PR:000014834 sharpin
References (Earliest) J:14539 HogenEsch H, et al., A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice. Am J Pathol. 1993 Sep;143(3):972-82
(Latest) J:205531 Pouwels J, et al., SHARPIN regulates uropod detachment in migrating lymphocytes. Cell Rep. 2013 Nov 14;5(3):619-28
All references(63)
Other
accession IDs
MGD-MRK-2104, MGI:2146193, MGI:88480

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory