About   Help   FAQ
Sharpin
Gene Detail
Symbol

Name
ID
Sharpin
SHANK-associated RH domain interacting protein
MGI:1913331
Synonyms
0610041B22Rik, cpdm, SIPL1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
35.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:76347040-76351111 bp, - strand
From VEGA annotation of GRCm38

  4072 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11918  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: SHARPIN
Gene Tree: Sharpin

Human
homologs
SHARPIN, SHANK-associated RH domain interactor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 81858
neXtProt AC: NX_Q9H0F6

Human Synonyms: SIPL1

Human Chr (Location): 8q24.3; chr8:144098633-144104237 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Radiation induced(1) Spontaneous(2) Targeted(2) Transgenic(1)
Genomic Mutations involving Sharpin (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene produces chronic skin lesions.
 
Human Diseases Modeled in Mice Using Sharpin (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Sharpin interacts with 37 markers (Mir128-1, Mir128-2, Mir191, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process apoptotic nuclear changes, epidermis development, ...
Component cell junction, cytoplasm, ...
Function identical protein binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(65)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN sharpin    NEW 
Molecular
reagents
All nucleic(65) cDNA(65)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023724 (Evidence)
Ensembl Gene Model ENSMUSG00000022552 (Evidence)
Entrez Gene 106025 (Evidence)
UniGene 41463
DFCI TC1575016, TC1588153, TC1603286
DoTS DT.101357524, DT.55221338, DT.91411059, DT.94259358, DT.97361201
NIA Mouse Gene Index U036341
Consensus CDS Project CCDS37121.1
International Mouse Phenotyping Consortium Status Sharpin
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023724 VEGA Gene Model | MGI Sequence Detail 4072 C57BL/6J ±  kb
transcript OTTMUST00000057935 VEGA | MGI Sequence Detail 1734 Not Applicable 
polypeptide OTTMUSP00000028019 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(9) UniProt(3)
Polymorphisms
SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026168 SHARPIN
InterPro IPR029071 Ubiquitin-related domain
InterPro IPR001876 Zinc finger, RanBP2-type
Protein Ontology PR:000014834 sharpin
References
(Earliest) J:14539 HogenEsch H, et al., A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice. Am J Pathol. 1993 Sep;143(3):972-82
(Latest) J:219574 MacDuff DA, et al., Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection. Elife. 2015;4
All references(65)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-2104, MGI:2146193, MGI:88480

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory