Sharpin
Gene Detail

Symbol Name ID

Sharpin SHANK-associated RH domain interacting protein MGI:1913331

Synonyms

0610041B22Rik, cpdm, SIPL1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

35.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:76347040-76351111 bp, - strand From VEGA annotation of GRCm38   4072 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11918  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Sharpin

Human homologs

Human Homolog		SHARPIN, SHANK-associated RH domain interactor
NCBI Gene ID		81858
neXtProt AC		NX_Q9H0F6
Human Synonyms		SIPL1
Human Chr (Location)		8q24.3; chr8:145153536-145159140 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(2) Gene trapped(2) Spontaneous(2)
 

Mutations in this gene produces chronic skin lesions.

 
Human Diseases Modeled Using Mouse Sharpin (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	apoptotic nuclear changes, epidermis development, ...
Component	cytoplasm, cytosol, ...
Function	identical protein binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(65) cDNA(65)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023724 (Evidence)
Ensembl Gene Model	ENSMUSG00000022552 (Evidence)
Entrez Gene	106025 (Evidence)
UniGene	41463
DFCI	TC1575016, TC1588153, TC1603286
DoTS	DT.101357524, DT.55221338, DT.91411059, DT.94259358, DT.97361201
NIA Mouse Gene Index	U036341
Consensus CDS Project	CCDS37121.1
International Mouse Knockout Project Status	Sharpin

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023724	VEGA Gene Model | MGI Sequence Detail	4072	C57BL/6J
transcript	OTTMUST00000057935	VEGA | MGI Sequence Detail	1734	Not Applicable
polypeptide	OTTMUSP00000028019	VEGA | MGI Sequence Detail	380	Not Applicable

All sequences(60) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026168	SHARPIN
InterPro	IPR001876	Zinc finger, RanBP2-type
Protein Ontology	PR:000014834	sharpin

References

(Earliest) J:14539 HogenEsch H, et al., A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice. Am J Pathol. 1993 Sep;143(3):972-82
(Latest) J:188020 Damgaard RB, et al., The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell. 2012 Jun 29;46(6):746-58
All references(61)

Other accession IDs

MGD-MRK-2104, MGI:2146193, MGI:88480