Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Shank1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SHANK1
- Mouse genes Shank1
- Rat genes Shank1
- Zfish genes shank1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Shank1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071532	ankyrin repeat binding	Shank1	IPI	UniProtKB:Q9WV48	Rat	PMID:15496675\|RGD:8553458
Molecular Function	GO:0001664	G protein-coupled receptor binding	Shank1	IPI	RGD:620768	Rat	PMID:10958799\|RGD:633972
Molecular Function	GO:0042802	identical protein binding	Shank1	IPI	UniProtKB:Q9WV48	Rat	PMID:15496675\|RGD:8553458
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Shank1	IPI	UniProtKB:Q61625	Mouse	MGI:MGI:3852309\|PMID:15207857
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Shank1	IPI	UniProtKB:P23818	Mouse	MGI:MGI:3624607\|PMID:16606358
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Shank1	IPI	RGD:2738	Rat	PMID:20171009\|RGD:4107021
Molecular Function	GO:0005515	protein binding	SHANK1	IPI	UniProtKB:P30874	Human	PMID:10551867
Molecular Function	GO:0005515	protein binding	SHANK1	IPI	UniProtKB:P50570	Human	PMID:11583995
Molecular Function	GO:0005515	protein binding	SHANK1	IPI	UniProtKB:Q15349	Human	PMID:30126976
Molecular Function	GO:0005515	protein binding	SHANK1	IPI	UniProtKB:Q9BYF1	Human	PMID:33436498
Molecular Function	GO:0005515	protein binding	SHANK1	IPI	UniProtKB:Q9BYF1	Human	PMID:34835087
Molecular Function	GO:0005515	protein binding	Shank1	IPI	UniProtKB:Q9EP53	Mouse	MGI:MGI:5014114\|PMID:21653829
Molecular Function	GO:0005515	protein binding	Shank1	IPI	UniProtKB:P31016	Rat	PMID:10433268\|RGD:68848
Molecular Function	GO:0005515	protein binding	Shank1	IPI	UniProtKB:P97836	Rat	PMID:10433268\|RGD:68848
Molecular Function	GO:0005515	protein binding	Shank1	IPI	UniProtKB:P97836-5	Rat	PMID:10433268\|RGD:68848
Molecular Function	GO:0005515	protein binding	Shank1	IPI	UniProtKB:P97836	Rat	PMID:10488079\|RGD:633975
Molecular Function	GO:0005515	protein binding	Shank1	IPI	UniProtKB:P31016	Rat	PMID:11178875\|RGD:633925
Molecular Function	GO:0005515	protein binding	Shank1	IPI	UniProtKB:P97836	Rat	PMID:11178875\|RGD:633925
Molecular Function	GO:0005515	protein binding	Shank1	IPI	UniProtKB:Q9EQL9	Rat	PMID:11178875\|RGD:633925
Molecular Function	GO:0005515	protein binding	Shank1	IPI	RGD:621714	Rat	PMID:11509555\|RGD:628460
Molecular Function	GO:0005515	protein binding	Shank1	IPI	UniProtKB:Q9ES28-2	Rat	PMID:12626503\|RGD:8553890
Molecular Function	GO:0005515	protein binding	Shank1	IPI	UniProtKB:Q9NSC5	Rat	PMID:19345194\|RGD:8553291
Molecular Function	GO:0005515	protein binding	Shank1	IPI	UniProtKB:Q9Z214-2	Rat	PMID:19345194\|RGD:8553291
Molecular Function	GO:0044877	protein-containing complex binding	Shank1	IPI	RGD:631353\|RGD:68424\|RGD:621667\|RGD:620223	Rat	PMID:11178875\|RGD:633925
Molecular Function	GO:0097110	scaffold protein binding	Shank1	IPI	UniProtKB:Q9Z214	Rat	PMID:10433269\|RGD:8554380
Molecular Function	GO:0017124	SH3 domain binding	Shank1	IPI	UniProtKB:Q9WV48	Rat	PMID:15496675\|RGD:8553458
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	Shank1	IDA		Rat	PMID:10958799\|RGD:633972
Molecular Function	GO:0031877	somatostatin receptor binding	Shank1	IPI	UniProtKB:P30680	Rat	PMID:10551867\|RGD:8554584
Molecular Function	GO:0098919	structural constituent of postsynaptic density	Shank1	IDA		Mouse	PMID:18272690
Molecular Function	GO:0098919	structural constituent of postsynaptic density	Shank1	IMP		Mouse	PMID:18272690
Molecular Function	GO:0098919	structural constituent of postsynaptic density	Shank1	IEP		Mouse	PMID:18272690
Molecular Function	GO:0030160	synaptic receptor adaptor activity	Shank1	IMP		Mouse	MGI:MGI:3775591\|PMID:18272690
Molecular Function	GO:0030160	synaptic receptor adaptor activity	Shank1	IDA		Rat	PMID:10433269\|RGD:8554380
Cellular Component	GO:0030425	dendrite	Shank1	IDA		Mouse	MGI:MGI:5294265\|PMID:21940441
Cellular Component	GO:0043197	dendritic spine	Shank1	IDA		Mouse	MGI:MGI:3852309\|PMID:15207857
Cellular Component	GO:0043197	dendritic spine	Shank1	IDA		Rat	PMID:15496675\|RGD:8553458
Cellular Component	GO:0060076	excitatory synapse	Shank1	IDA		Mouse	MGI:MGI:3775591\|PMID:18272690
Cellular Component	GO:0098978	glutamatergic synapse	Shank1	IDA		Mouse	PMID:18272690
Cellular Component	GO:0098978	glutamatergic synapse	Shank1	IEP		Mouse	PMID:18272690
Cellular Component	GO:0098978	glutamatergic synapse	Shank1	IMP		Mouse	PMID:18272690
Cellular Component	GO:0016020	membrane	SHANK1	IDA		Human	PMID:10551867
Cellular Component	GO:0043005	neuron projection	Shank1	IDA		Mouse	MGI:MGI:5320264\|PMID:21795692
Cellular Component	GO:0005886	plasma membrane	SHANK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Shank1	IDA		Mouse	MGI:MGI:3852309\|PMID:15207857
Cellular Component	GO:0014069	postsynaptic density	Shank1	IDA		Mouse	MGI:MGI:5816444\|PMID:21144999
Cellular Component	GO:0014069	postsynaptic density	Shank1	IDA		Mouse	PMID:18272690
Cellular Component	GO:0014069	postsynaptic density	Shank1	IDA		Rat	PMID:10433269\|RGD:8554380
Cellular Component	GO:0045211	postsynaptic membrane	Shank1	IDA		Mouse	MGI:MGI:3852309\|PMID:15207857
Cellular Component	GO:0045211	postsynaptic membrane	Shank1	IDA		Mouse	PMID:15950311
Cellular Component	GO:0045211	postsynaptic membrane	Shank1	IDA		Rat	PMID:10958799\|RGD:633972
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Shank1	IEP		Mouse	PMID:18272690
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Shank1	IDA		Mouse	PMID:18272690
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Shank1	IMP		Mouse	PMID:18272690
Cellular Component	GO:0045202	synapse	Shank1	IDA		Rat	PMID:15496675\|RGD:8553458
Biological Process	GO:0030534	adult behavior	SHANK1	IMP		Human	PMID:22503632
Biological Process	GO:0008306	associative learning	Shank1	IMP		Mouse	MGI:MGI:3775591\|PMID:18272690
Biological Process	GO:0060997	dendritic spine morphogenesis	Shank1	IMP		Mouse	MGI:MGI:3775591\|PMID:18272690
Biological Process	GO:0050894	determination of affect	SHANK1	IMP		Human	PMID:22503632
Biological Process	GO:0046959	habituation	Shank1	IMP		Mouse	MGI:MGI:5086047\|PMID:21695253
Biological Process	GO:0007616	long-term memory	Shank1	IMP		Mouse	MGI:MGI:3775591\|PMID:18272690
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Shank1	IDA		Mouse	PMID:18272690
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Shank1	IEP		Mouse	PMID:18272690
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Shank1	IMP		Mouse	PMID:18272690
Biological Process	GO:0032232	negative regulation of actin filament bundle assembly	Shank1	IDA		Mouse	PMID:19208628
Biological Process	GO:0050885	neuromuscular process controlling balance	Shank1	IMP		Mouse	MGI:MGI:4947212\|PMID:20868654
Biological Process	GO:0042048	olfactory behavior	Shank1	IMP		Mouse	MGI:MGI:5086047\|PMID:21695253
Biological Process	GO:0060999	positive regulation of dendritic spine development	Shank1	IDA		Rat	PMID:18287537\|RGD:8553517
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Shank1	IMP		Mouse	MGI:MGI:3775591\|PMID:18272690
Biological Process	GO:0035418	protein localization to synapse	Shank1	IMP		Mouse	MGI:MGI:3775591\|PMID:18272690
Biological Process	GO:0065003	protein-containing complex assembly	Shank1	IDA		Rat	PMID:10433269\|RGD:8554380
Biological Process	GO:2000311	regulation of AMPA receptor activity	Shank1	IMP		Mouse	MGI:MGI:3775591\|PMID:18272690
Biological Process	GO:0060013	righting reflex	Shank1	IMP		Mouse	MGI:MGI:5086047\|PMID:21695253
Biological Process	GO:0035176	social behavior	SHANK1	IMP		Human	PMID:22503632
Biological Process	GO:0035176	social behavior	Shank1	IMP		Mouse	MGI:MGI:5086047\|PMID:21695253
Biological Process	GO:0060074	synapse maturation	Shank1	IDA		Rat	PMID:18287537\|RGD:8553517
Biological Process	GO:0071625	vocalization behavior	SHANK1	IMP		Human	PMID:22503632
Biological Process	GO:0071625	vocalization behavior	Shank1	IMP		Mouse	MGI:MGI:5086047\|PMID:21695253

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.